Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease...
13 KB (1,469 words) - 19:11, 24 June 2024
Apoptotic caspases are subcategorised as: Initiator Caspases (Caspase 2, Caspase 8, Caspase 9, Caspase 10) Executioner Caspases (Caspase 3, Caspase 6 and...
28 KB (3,113 words) - 05:35, 29 April 2024
of Leu-Gln-Thr-Asp!Gly Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62). Chang...
2 KB (249 words) - 19:10, 24 June 2024
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals...
20 KB (2,278 words) - 19:10, 24 June 2024
Apoptosis (redirect from Caspase-mediated cell death)
of caspases: initiator caspases (caspases 2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires...
91 KB (10,659 words) - 18:24, 25 August 2024
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues...
35 KB (4,330 words) - 02:13, 24 June 2024
form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and...
6 KB (669 words) - 19:11, 24 June 2024
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous...
29 KB (3,392 words) - 19:09, 24 June 2024
in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing...
20 KB (2,410 words) - 06:29, 3 June 2024
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
21 KB (2,394 words) - 03:59, 17 June 2024
CARD (domain) (redirect from Caspase recruitment domain)
Caspase recruitment domains, or caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically...
15 KB (1,429 words) - 20:45, 30 May 2024
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation...
35 KB (3,948 words) - 06:00, 10 June 2024
Death regulator Nedd2-like caspase (Nc, Nedd2-like caspase or Dronc) was firstly identified and characterised in Drosophila in 1999 as a cysteine protease...
43 KB (4,796 words) - 22:36, 25 April 2024
Val-Asp-Val-Ala-Asp- Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). Kumar...
3 KB (379 words) - 22:42, 24 June 2024
a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen, which contains...
8 KB (921 words) - 19:12, 24 June 2024
accessory criterion. 2003 nomenclature IA - Fas IB - Fas ligand IIA - Caspase 10 IIB - Caspase 8 III - unknown IV - Neuroblastoma RAS viral oncogene homolog Revised...
26 KB (2,502 words) - 02:54, 15 July 2024
dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody...
10 KB (1,190 words) - 05:34, 10 July 2024
called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and...
2 KB (168 words) - 22:42, 24 June 2024
(LPS) by caspase-11, which subsequently induces pyroptotic cell death.[doi:10.1038/nri.2016.58] In human cells, the corresponding caspases of the non-canonical...
71 KB (7,823 words) - 11:34, 29 July 2024
Fas receptor (category Genes on human chromosome 10)
heterotetramer enzyme. Active caspase-8 is then released from the DISC into the cytosol, where it cleaves other effector caspases, eventually leading to DNA...
23 KB (2,675 words) - 19:25, 12 November 2023
Caspase-8 deficiency (CEDS) is a very rare genetic disorder of the immune system. It is caused by mutations in the CASP8 gene that encodes the protein...
8 KB (822 words) - 15:23, 2 January 2024
Murine caspase-11, and its human homologs caspase-4 and caspase-5, are mammalian intracellular receptor proteases activated by TLR4 and TLR3 signaling...
11 KB (1,388 words) - 00:36, 3 January 2024
proteases called caspases. It is an inflammatory caspase, along with caspase 1, caspase 4 and the murine caspase 4 homolog caspase 11, and has a role...
1 KB (103 words) - 19:11, 24 June 2024
protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Caspase 6 can also undergo...
13 KB (1,632 words) - 03:48, 19 August 2024
further caspases, initiating the caspase cascade. The activated caspases can go on to cleave intracellular proteins such as inhibitor of caspase-activated...
34 KB (4,191 words) - 16:39, 21 December 2023
Caspase 12 is a protein that in humans is encoded by the CASP12 gene. The protein belongs to a family of enzymes called caspases which cleave their substrates...
6 KB (665 words) - 07:46, 7 July 2024
Caspase 13 or ERICE ("evolutionarily related interleukin-1β converting enzyme") is a protein that was identified in cattle. It belongs to a family of...
2 KB (169 words) - 22:36, 25 April 2024
Caspase-activated DNase (CAD) or DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene. It breaks up the DNA during...
25 KB (3,047 words) - 19:09, 24 June 2024
the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication. In...
14 KB (1,667 words) - 20:15, 23 April 2024
Caspase recruitment domain-containing protein 8 is a protein that in humans is encoded by the CARD8 gene. Caspase recruitment domain (CARD)-containing...
5 KB (566 words) - 21:57, 8 March 2024