along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands. Cytosines in CpG dinucleotides can be methylated...

methylated CpG site (a cytosine followed by guanine along its 5' → 3' direction and where the cytosine is methylated (5-mCpG)). A 5-mCpG site has the lowest...

CpG may refer to: CpG site - methylated sequences of DNA significant in gene regulation CpG island - regions of DNA that contain several CpG sites CpG...

occurs on the cytosine nucleotide in a CpG site, in plants the cytosine can be methylated at CpG, CpHpG, and CpHpH sites, where H represents any nucleotide...

(CpG sites). In the mouse brain, 4.2% of all cytosines are methylated, primarily in the context of CpG sites, forming 5mCpG. Most hypermethylated 5mCpG...

methylated CpG site (a cytosine followed by guanine along its 5' → 3' direction and where the cytosine is methylated (5-mCpG)). A 5-mCpG site has the lowest...

differentially methylated CpG sites returned to the level of never-smokers within five years of smoking cessation. However, 2,568 CpGs among 942 genes remained...

CpG site). In mammals, DNA methyltransferases (which add methyl groups to DNA bases) exhibit a strong sequence preference for cytosines at CpG sites....

a demethylation pathway shown in the second figure. The thousands of CpG sites being demethylated during memory formation depend on ROS in an initial...

transcription start site of a gene (proximal promoters) contain a CpG island. CpG islands are generally 200 to 2000 base pairs long, have a C:G base pair content...

diabetes. In a normal cell, the bulk genome is highly methylated at CpGs, whereas CpG islands (CPI) at gene promoter regions remain highly unmethylated...

occurs in the DNA sequence CpG, changing the DNA at the CpG site from CpG to 5-mCpG. Methylation of cytosines in CpG sites in promoter regions of genes...

mammalian brain, ~62% of CpGs are methylated. Methylation of CpG sites tends to stably silence genes. More than 500 of these CpG sites are de-methylated in...

along its 5' → 3' direction (at CpG sites). This forms a 5mCpG site. More than 98% of DNA methylation occurs at CpG sites in mammalian somatic cells. Thus...

of CpG dinucleotides (CpG sites), forming 5-methylcytosine (5mC). Thus, a CpG site may be methylated to form 5mCpG. The presence of 5mC at CpG sites in...

Verbascoside) Calorically perfect gas Clopidogrel CpG ODN, a synthetic TLR9 agonist CpG site, a site in DNA CpG island, a specialized region of DNA Central...

guanine, a CpG site. The number of CpG sites in the human genome is about 28 million. Depending on the type of cell, about 70% of the CpG sites have a methylated...

at a CpG site, which is a cytosine followed by a guanine. The “p” refers to the phosphate linker between them. DMR usually involves adjacent sites or a...

controlled by methylation of cytosines within CpG dinucleotides (where 5' cytosine is followed by 3' guanine or CpG sites). 5-methylcytosine (5-mC) is a methylated...

mouse sperm genome is 80–90% methylated at its CpG sites in DNA, amounting to about 20 million methylated sites.[citation needed] After fertilization, the...

(G) within CpG sites. This is an important repair function since about 1/3 of all intragenic single base pair mutations in human cancers occur in CpG dinucleotides...

MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The...

or 5-mCpG). Methylated cytosines within CpG sequences often occur in groups, called CpG islands. About 59% of promoter sequences have a CpG island while...

the nervous system. This disruption leads to an elevation in methylated CpG sites, causing DNA hypermethylation. The mutations can either occur due to new...

the bisulfite-converted sequence of specific CpG sites in the region. The ratio of C-to-T at individual sites can be determined quantitatively based on the...

sequence, a CpG site.) Methylation of CpG sites in a promoter region of a gene usually represses gene transcription, while methylation of CpGs in the body...

methylation. DNA methylation of a CpG island in a promoter region may cause silencing of its downstream gene (see CpG site and regulation of transcription...

DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing or causing genes...

methylation of CpG sites seems to be the default. Human DNA has about 80–90% of CpG sites methylated, but there are certain areas, known as CpG islands, that...

modification primarily occurs at CpG sites, which in turn tend to cluster in regions called CpG islands. There is a small fraction of CpG islands that can overlap...