Decitabine (i.e., 5-aza-2′-deoxycytidine), sold under the brand name Dacogen among others, acts as a nucleic acid synthesis inhibitor. It is a medication...
9 KB (716 words) - 04:12, 4 June 2024
Decitabine/cedazuridine, sold under the brand name Inqovi among others, is a fixed-dose combination anticancer medication used for the treatment of adults...
15 KB (1,175 words) - 04:47, 15 July 2024
and RNA.[medical citation needed] Azacitidine and its deoxy derivative, decitabine (also known as 5-aza-2′-deoxycytidine) were first synthesized in Czechoslovakia...
20 KB (1,915 words) - 00:12, 31 March 2024
myeloid leukemia (AML). For this purpose it is used with azacitidine, decitabine, or low-dose cytarabine for newly diagnosed adults who are age 75 years...
27 KB (2,575 words) - 15:22, 28 October 2024
Azacitidine Azathioprine Capecitabine Cladribine Clofarabine Cytarabine Decitabine Doxifluridine Fludarabine Fluorouracil Gemcitabine Hydroxyurea Mercaptopurine...
5 KB (324 words) - 12:07, 20 July 2024
hypomethylating agent decitabine has shown a similar survival benefit to azacitidine and has a response rate as high as 43%. Decitabine is available in combination...
61 KB (6,719 words) - 14:44, 6 November 2024
DNMT inhibitors). Currently two members of the class, azacitidine and decitabine, are FDA-approved for use in the United States in myelodysplastic syndrome...
4 KB (438 words) - 06:54, 17 March 2024
sensitize the tumerogenic cells to hypomethylating chemotheraputics such as decitabine. Many types of cancer (e.g. gastric) are known for having aberrant epigenetic...
20 KB (2,249 words) - 15:08, 21 April 2024
Azacitidine L01BC08 Decitabine L01BC09 Floxuridine L01BC52 Fluorouracil, combinations L01BC53 Tegafur, combinations L01BC58 Decitabine, combinations L01BC59...
12 KB (877 words) - 15:36, 25 January 2024
Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (decitabine) are the most commonly used demethylating agents. They work by inhibiting...
8 KB (993 words) - 23:08, 1 July 2024
nucleotides Daunorubicin, Doxorubicin, Epirubicin Enzyme inhibitors inhibit enzymes that are crucial to DNA replication Decitabine, Etoposide, Irinotecan...
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specializing in oncology, for US$3.9 billion. This event brought Dacogen (decitabine), Aloxi (palonosetron), Hexalen (altretamine) for ovarian cancer, and...
12 KB (887 words) - 23:00, 12 November 2024
being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation. In...
7 KB (442 words) - 15:25, 24 May 2024
causes hypomethylation of DNA by inhibition of DNA methyltransferase. Decitabine is a similar drug to azacitidine and is approved by the FDA for treatments...
25 KB (2,922 words) - 14:19, 29 August 2023
drug. The deoxynucleoside analogues include cytarabine, gemcitabine, decitabine, azacitidine, fludarabine, nelarabine, cladribine, clofarabine, and pentostatin...
155 KB (17,518 words) - 23:36, 26 October 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
31 KB (2,908 words) - 06:38, 22 September 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
37 KB (3,397 words) - 01:51, 12 November 2024
originated also other nucleoside compounds which became approved drugs: Decitabine used in the treatment of acute myeloid leukemia and Azacytidine for myelodysplastic...
9 KB (883 words) - 21:14, 7 November 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
18 KB (1,637 words) - 04:59, 12 November 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
19 KB (1,757 words) - 09:15, 29 October 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
9 KB (716 words) - 15:15, 27 October 2024
atherosclerotic lesion. An ex vivo experiment using the demethylating agent Decitabine (5-aza-2 -deoxycytidine) was shown to induce MCT3 expression in a dose...
116 KB (13,328 words) - 15:58, 8 November 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
15 KB (1,437 words) - 03:54, 17 October 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
61 KB (6,086 words) - 22:34, 7 November 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
31 KB (2,832 words) - 13:30, 20 September 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
14 KB (1,105 words) - 06:03, 14 September 2024
Clofarabine Cyclophosphamide Cytosine arabinoside Dasatinib Daunorubicin Decitabine Etoposide Fludarabine Gemtuzumab ozogamicin Idarubicin Imatinib mesylate...
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Myelodysplastic Syndrome with Excess Blasts Progressing on or After Azacitidine or Decitabine". 29 June 2020. Jost, M (2017). "Combined CRISPRi/a-Based Chemical Genetic...
3 KB (146 words) - 00:11, 7 May 2023
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
4 KB (128 words) - 11:38, 22 April 2024
reductase inhibitor (Gemcitabine#) Hypomethylating agent (Azacitidine Decitabine) Deoxyribonucleotide Ribonucleotide reductase inhibitor (Hydroxycarbamide#)...
5 KB (210 words) - 06:16, 5 July 2024