Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway...

IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining...

inversely related to its half maximal effective concentration (EC50) value. The EC50 can be measured for a given agonist by determining the concentration...

as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC50 curve...

as a strong non-competitive selective NMDA receptor antagonist, with an EC50 of 20 μM; which might promote sedation in addition with the strong antihistaminergic...

compared to D9-THC (1.6x). 9R-HHC has an EC50 of 3.4nM ± 1.5nM at CB1 and 6.2nM ± 2.1nM at CB2 while 9S-HHC has an EC50 of 57nM ± 19nM at CB1 and 55nM ± 10nM...

the CB1 receptors with an EC50 of 44.4nM for 9R-HHCP and 134nM for 9S-HHCP. Compared to Hexahydrocannabinol (HHC) with an EC50 of 101nM for 9R-HHC and 1...

eliciting 50% of its maximal effect (half maximal effective concentration = EC50) at the human 5-HT2A receptor in vitro are in the 0.118–0.983 μmol/L range...

on binding affinity. Potency of drug is the measure of its effectiveness, EC50 is the drug concentration of a drug that produces an efficacy of 50% and...

EK45 Westover March 9, 2000 Socorro LINEAR  · 4.0 km MPC · JPL 17237 2000 EC50 — March 7, 2000 Višnjan Observatory K. Korlević  · 2.9 km MPC · JPL 17238...

inhibition at CB1 it displays a similar efficacy to that of Δ9-THC (EC50 = 11 nM vs. EC50 = 5.2 nM, respectively), but a lower maximum response (Emax = 28%...

inserting a letter after the digit and before the space: EC1–EC4 (but not EC50), SW1, W1, WC1, WC2 and parts of E1 (E1W), N1 (N1C and N1P), NW1 (NW1W) and...

toxicology, there are some other safety factors including LD50, LC50 and EC50. Threshold dose is a dose of drug barely adequate to produce a biological...

among individual plants and populations.}}}} Notes: In brackets is the IC50/EC50 value depending on whether it is an inhibitory or inductive action being...

(Ki = 0.9 nM; EC50 = 13.0 nM; IATooltip intrinsic activity = 89%) and κ-opioid receptor (Ki = 2.6 nM; EC50 = 17 nM; IA = 67%). The EC50 values of 0.5–5...

is a non-selective opioid receptor ligand, so this is not MOR-specific.) EC50 is for hMOR1 GTPyS binding. Cmax and AUC levels are for 20 mg CR oxycodone...

estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting...

activity of solriamfetol at human, mouse, and rat TAAR1 receptors. hTAAR1 EC50 values (10–16 μM) were within the clinically observed therapeutic solriamfetol...

act as a partial agonist of the κ-opioid receptor at high concentrations (EC50 = 7.2 μM). Antagonism of the α2-adrenergic receptors, which function largely...

HCN1Tooltip Hyperpolarization-activated cyclic nucleotide-gated channel 1 8–16 EC50 Inhibitor Mouse TRPV1 1-100 Ki Agonist Rat The smaller the value, the stronger...

interactions with the other serotonin receptors. Whereas vortioxetine has IC50 or EC50 values of 5.4 nM for the SERT and 12 nM for the 5-HT3 receptor, its values...

comparing the change in the dose ratio, the ratio of the EC50 of an agonist alone compared to the EC50 in the presence of a competitive antagonist as determined...

Protective index Median toxic dose (TD50) Lowest published lethal dose (LDLo) EC50 (half maximal effective concentration) IC50 (half maximal inhibitory concentration)...

Guinea pig σ2 136 Agonist Rat D2 >10,000 ND Human   D2High 2.7–4.3 144 (EC50) Partial Agonist Rat/human Human 5-HT2A 6.7 – 39 Partial agonist Human SERTTooltip...

potencies (REPs) were calculated from half-maximal effective concentrations (EC50) that were determined via in-vitro β‐galactosidase (β-gal) and green fluorescent...

testosterone. The EC50 of DHT for activation of the AR is 0.13 nM, which is about 5-fold stronger than that of testosterone (EC50 = 0.66 nM). In bioassays...

15,000 HDAC9 2,000,000 Lower bound CA1 511,000 CA2 1,032,000 GPCR target pEC50 Entry note FFAR2 2.9–4.6 Full agonist FFAR3 3.8–4.9 Full agonist HCA2 2.8...

agonist of the glucocorticoid receptor (GR), albeit with very low potency (EC50 >100-fold less relative to cortisol). Progesterone, through its neurosteroid...

the 5-HT2A receptor, with an EC50 of 185.7 nM and an efficacy of 28.7% (vs 5-HT), and a full agonist at 5-HT2C with an EC50 of 89.7 nM and an efficacy of...

L-norpseudoephedrine acts as a releasing agent of norepinephrine (EC50 = 30 nM) and to a lesser extent of dopamine (EC50 = 294 nM). Due to the 10-fold difference in its...