FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to...

proliferation of effector T cells. Treg cells express the biomarkers CD4, FOXP3, and CD25 and are thought to be derived from the same lineage as naïve CD4+...

IPEX is caused by mutations in the gene FOXP3, which encodes transcription factor forkhead box P3 (FOXP3). FOXP3 is widely considered to be the master regulator...

X-linked syndrome (IPEX syndrome) is X-linked recessive due to mutation of the FOXP3 gene on the X chromosome. Most patients develop diabetes and diarrhea and...

tumor. Forkhead box protein 3 (Foxp3) as a transcription factor is an essential molecular marker of Treg cells. Foxp3 polymorphism (rs3761548) might be...

thymus. Two major classes of CD4+ Treg cells have been described—FOXP3+ Treg cells and FOXP3− Treg cells. Regulatory T cells can develop either during normal...

acetylation in the promoter and conserved non-coding sequence regions of the FOXP3 locus, thus regulating the T cells, resulting in the reduction of the inflammatory...

factor beta (TGF-β). Th3 have been described both in mice and human as CD4+FOXP3− regulatory T cells. Th3 cells were first described in research focusing...

of developing asthma. Studies have shown a positive correlation between Foxp3 methylation and children's exposure to NO2, CO, and PM2.5. Furthermore,...

nTreg cells develop from Foxp3- CD25+ CD4+ cells while iTreg cells develop from Foxp3+ CD25- CD4- cells (both become Foxp3+ CD25+CD4+). nTreg cells,...

known for his research on regulatory T cells and the transcription factor Foxp3. Rudensky received his Candidate of Sciences degree in 1986 from the Gabrichevsky...

secretion of TGF-β (inhibitor of cytokine production), and mutations of FoxP3, an essential regulatory factor for the Tregs development. Development of...

FOXP3. However, eventually most of these cells downregulate their regulatory capabilities and become effector cells. Thus, attempts to induce FOXP3+...

(hyperplastic, hypersecretory gastropathy), and intestinal metaplasia. In addition, Foxp3 polymorphism (rs3761548) might contribute to gastric cancer development...

forkhead box protein 3 (FOXP3) as a transcription factor is an essential molecular marker of regulatory T (Treg) cells. FOXP3 polymorphism (rs3761548)...

(rs3761548) is amongst the SNPs locating in the promoter region of the Foxp3 gene, might be involved in cancer progression. A SNP in the F5 gene causes...

to become "suppressor" cells. Suppressor T cells are also known as CD25+–Foxp3+ regulatory T cells (nTregs), and reduce inflammation. Negoro T, Iinuma...

expression of HLA‐DR2 and HLA‐DR15 (mean age of two groups: 34 and 21 years), FOXP3, CD95, and CCR4; lower expression of CD45RA (mean age: 45 years); and expression...

the FOXP3 gene found on the X chromosome. The Scurfin protein, which regulates the development of CD4+CD25+ regulatory T cells, is encoded by FOXP3. DNA-binding...

mofetil-based immunosuppression changes the frequency and phenotype of CD4+FOXP3+ regulatory T cells". Transplantation. 87 (7): 1062–1068. doi:10.1097/tp...

Forkhead box protein 3 (Foxp3) as a transcription factor is an essential molecular marker of regulatory T (Treg) cells. Foxp3 polymorphism (rs3761548)...

the expression of Gata3 and FoxP3 genes. The colonization of Clostridium spp. can enhance the aggregation of RORγT+ FOXP3 Treg cells, which inhibit the...

immunity-related genes AIRE (causing autoimmune polyglandular syndrome), FoxP3 (causing IPEX syndrome), or STAT3 include type 1 diabetes in their effects...

tolerance. Tregs, characterized by the expression of the transcription factor Foxp3, exert immunosuppressive effects by inhibiting the activation and function...

der Vliet HJ, Nieuwenhuis EE (2007). "IPEX as a result of mutations in FOXP3". Clinical & Developmental Immunology. 2007: 1–5. doi:10.1155/2007/89017...

increases the ability of dendritic cells to convert naive thymocytes to a Foxp3+ regulatory T cell lineage. It is unknown if this is the physiological function...

implementation of self tolerance, which is mediated by CD4+CD25+Foxp3 nTreg cells. Foxp3 Treg development is supported by mTECs during negative selection...

inhibition on histone H3. In vitro, butyrate increases gene expression of FOXP3 (the transcription regulator for Tregs) and promotes colonic regulatory...

prevents allergy, but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure". Scientific Reports...

decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer". OncoImmunology. 6 (3): e1290034...