The fragment antigen-binding region (Fab region) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain...

complementary binding sites, called epitopes in antigens and paratopes in antibody. In an antibody, the Fab (fragment, antigen-binding) region is formed from...

partitioned into two antigen-binding fragments (Fab), containing one VL, VH, CL, and CH1 domain each, as well as the crystallisable fragment (Fc), forming the...

therapeutics, the Fc region of immunoglobulins has been engineered to contain an antigen-binding site. This type of antigen-binding fragment is called Fcab...

specific for a certain antigen or surface component, bind to the pathogen with their Fab region (fragment antigen binding region), their Fc regions point...

cytometry, immunohistochemistry, and as antigen-binding domains of artificial T cell receptors (chimeric antigen receptor). Unlike monoclonal antibodies...

antigen-binding site, is the part of an antibody which recognizes and binds to an antigen. It is a small region at the tip of the antibody's antigen-binding...

resisting. Hinge region portion of antibody structure between the fragment antigen-binding region and the fragment crystallizable region Living hinge a...

the latter portion of the endogenous pathway (e.g. proteolysis of antigens for binding to MHC I molecules). While the joint distinction between the two...

antibodies to that specific antigen. Self-antigens are suppressed by regulatory T cells. Predicting which (fragments of) antigens will be presented to the...

are composed of two fragments: antigen binding region (Fab region) and the fragment crystallizable region (Fc region). The Fab region is able to bind to...

the new ability to target a specific antigen. The receptors are chimeric in that they combine both antigen-binding and T cell activating functions into...

full function of MHC molecules: binding an antigen derived from self-proteins, or from pathogens, and bringing the antigen presentation to the cell surface...

between antigen-dependent and antigen-independent categories. These theories consider a specific combination of antigen peptide sequence and the binding groove...

antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With...

recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is...

contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining...

subunits to Fc fragments (made of CH2 region) of IgG or IgM, which has formed a complex with antigens. C4b and C3b are also able to bind to antigen-associated...

Fab: fragment, antigen-binding (one arm) F(ab')2: fragment, antigen-binding, including hinge region (both arms) Fab': fragment, antigen-binding, including...

into Fab (monomeric binding) or F(ab')2 (dimeric binding). The fragment antigen binding, or Fab, is the selective antigen binding region. An antibody, such...

the antigen binding region consists of the variable domains of the heavy and light chains (VH and VL). Heavy-chain antibodies can bind antigens despite...

and for production of IL-2. PD-L1 binding to PD-1 also contributes to ligand-induced TCR down-modulation during antigen presentation to naive T cells, by...

Lectins are carbohydrate-binding proteins that are highly specific for sugar groups that are part of other molecules, so cause agglutination of particular...

HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is a major histocompatibility...

on whether they bind to antigens or proteins directly or target another (primary) antibody that, in turn, is bound to an antigen or protein. A primary antibody...

engineered to generate artificial families of Antigen Binding Proteins (AgBP), capable of specific binding to different target proteins while retaining...

these single-stranded binding proteins are a heterotrimeric complex known as replication protein A (RPA). Each Okazaki fragment is preceded by an RNA...

by binding and neutralizing the pro-inflammatory cytokine, TNF-α. Multiple autoimmune disorders are caused by the binding of IgG to self antigens. Since...

"Protein A" after the antigen fraction isolated by Jensen. It has been shown via crystallographic refinement that the primary binding site for protein A...

in the preparation of F(ab')2 fragments from antibodies. In some assays, it is preferable to use only the antigen-binding (Fab) portion of the antibody...