Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from...

overexpression of Gli1 (Jacob and Briscoe, 2003). Gli1 has been shown to induce the two GLI2 α/β isoforms. Transgenic double homozygous Gli1-/- and Gli2-/-...

copy-number alterations that contribute to increased conversion of the oncogenes Gli1–3 into transcriptional activators by the Hedgehog signaling pathway are included...

activation of Shh-GLI1 cascades is caused by STIL's interaction with SUFU, which prevents SUFU from acting as a repressor of GLI1. Normally, GLI1 binds to the...

complex that recognizes H3K27me3. This occurs in a Gli-dependent manner, as Gli1 and Gli2 are downstream effectors of the Hedgehog signaling pathway. In culture...

- a fusion between the MALAT1 and GLI1 genes - has been described. This fusion causes over expression of the GLI1 protein and activation of the Sonic...

different Gli proteins are present, viz. Gli1, Gli2 and Gli3, which are expressed in the neural tube. Mice mutants for Gli1 show normal spinal cord development...

Greyhound Lines, a North-American bus carrier Volkswagen GLI, an automobile GLI1, GLI2, GLI3, glioma-associated family of transcription factors This disambiguation...

activation of genes. GANT-61 effectively reduced the DNA-binding affinity of GLI1 and GLI2 in multiple cancer cell lines, including rhabdomyosarcoma, osteosarcoma...

activation of the GLI transcription factors (Process "5"): the activators Gli1 and Gli2 and the repressor Gli3. The sequence of molecular events that connect...

C2H2 ZF Known motif – High-throughput in vitro [302] MAATCASDGCNNBBCACT GLI1 ENSG00000111087 C2H2 ZF Known motif – In vivo/Misc source [303] SMCCHCCCA...

Hedgehog signaling pathway. SMO inhibition causes the transcription factors GLI1 and GLI2 to remain inactive, which prevents the expression of tumor mediating...

allowing the cell to abruptly switch states at precise Shh concentrations. gli1 and gli2 transcription is activated by Shh, and their gene products act as...

PMID 11311120. Mao J, Maye P, Kogerman P, et al. (2002). "Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1". J. Biol. Chem. 277 (38):...

Gendron P, Romeo AA, Morris SJ, et al. (July 2014). "The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation". Nature. 511 (7507):...

SHH inhibits the Smoothened receptor. Activated smoothened in turn causes Gli1, Gli2, and Gli3 to be translocated into the nucleus where they activate target...

which a translocational mutation causes the fusion of the ACTB gene over GLI1 in Chromosome 12. Juvenile onset dystonia is a rare degenerative disease...

HGNC:29514 Q6ZMI3 6284 GLE1 HGNC:4315 Q53GS7 6285 GLG1 HGNC:4316 Q92896 6286 GLI1 HGNC:4317 P08151 6287 GLI2 HGNC:4318 P10070 6288 GLI3 HGNC:4319 P10071 6289...

Smoothened, leading to activation of the Gli family of transcription factors (GLI1, GLI2, and GLI3). In this context Shh acts as a morphogen - it induces cell...

part of the hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and hedgehog target genes cannot be transcribed...

different actions. For example, one study showed that there are proteins called Gli1, Gli2, and Gli3 that affect ventral hindbrain development, and are also required...

Koga K, Nakashima H, Yao T, Tsuneyoshi M, Tanaka M, Katano M (July 2006). "Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer...

Nakafuku M, Ishii S (March 1999). "Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3". The Journal of Biological Chemistry. 274 (12):...

Anguelov M, et al. (Oct 2020). "Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis"...

"Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis". Annals of Neurology...

pathway. There are three Gli factors that are essential for limb development: Gli1, Gli2 and Gli3. Without Shh, Gli2 and Gli3 are processed to a repressor form...

Hedgehog (HH) signaling pathway via interactions with HH transcription factor Gli1 and HH protein receptor Smo, often contributing to tumorigenesis. miR-324-5p's...

S.; Stephen, Daniel; Joyner, Alexandra L. (October 2002). "Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh...

Becker, Michael W.; Pei, Shanshan (2014-07-03). "The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation". Nature. 511 (7507):...

Philpott MP, Quinn AG (15 August 2002). "FOXM1 is a downstream target of Gli1 in basal cell carcinomas". Cancer Res. 62 (16): 4773–80. PMID 12183437. Kalinichenko...