Gamma secretase is a multi-subunit protease complex, an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within...
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Alzheimer's disease (redirect from Gamma secretase inhibition)
survival, and post-injury repair. In Alzheimer's disease, gamma secretase and beta secretase act together in a proteolytic process which causes APP to...
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amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent process and substrate...
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processed by beta secretase and gamma secretase. The alpha-secretase pathway is the predominant APP processing pathway. Thus, alpha-secretase cleavage precludes...
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Protein pigeon homolog (redirect from Gamma-secretase activating protein)
Protein pigeon homolog also known as gamma-secretase activating protein (GSAP) is a protein that in humans is encoded by the PION gene. The human PION...
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fragments.[citation needed] Sequential cleavage by beta-secretase 1 (BACE) and gamma-secretase (γ-secretase) produces the amyloid-beta peptide fragment that...
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the PSEN1 gene. Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation...
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transmembrane domain by γ-secretase releases the intracellular domain of APP and produces amyloid-β. Since gamma-secretase cleaves APP closer to the cell...
19 KB (2,159 words) - 03:21, 5 August 2024
(presenilin enhancer 2), is a protein that is a regulatory component of the gamma secretase complex, a protease complex responsible for proteolysis of transmembrane...
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transmembrane proteins which constitute the catalytic subunits of the gamma-secretase intramembrane protease protein complex. They were first identified...
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management of DT is strongly discouraged." Nirogacestat, a selective gamma secretase inhibitor, was approved for medical use in the United States in November...
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of the gamma secretase complex along with the catalytic subunit presenilin and the regulatory subunits nicastrin and PEN-2. The gamma-secretase complex...
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Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". The Journal of Biological...
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domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities". Neuromolecular Medicine. 1 (1): 43–54. doi:10.1385/NMM:1:1:43...
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studies identified that a modified version of imatinib can bind to gamma-secretase activating protein (GSAP). GSAP selectively increases the production...
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Nirogacestat (category Gamma secretase inhibitors)
medication used for the treatment of desmoid tumors. It is a selective gamma secretase inhibitor that is taken by mouth. The most common side effects include...
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Cleavage by gamma secretase within the membrane-spanning domain after beta-secretase cleavage generates the amyloid-beta fragment; gamma secretase is a large...
50 KB (5,683 words) - 05:16, 29 June 2024
Steven Wagner began screening for a class of drugs that they termed "gamma secretase modulators (GSM)". GSM's reverse the Abeta42:Abeta40 ratio and thereby...
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site. The discovery that caprolactam-type gamma-secretase inhibitors target the SPP subunit of the gamma-secretase, which has been implicated in Alzheimer's...
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RO4929097 (RG-4733) is a gamma secretase inhibitor being studied as an anti-cancer drug. Targeting gamma secretase inhibits NOTCH signaling, which is...
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DAPT (chemical) (category Gamma secretase inhibitors)
A.; Steiner, H.; Willem, M.; Bally-Cuif, L.; Haass, C. (2002). "A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic...
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Nuclear Compton Telescope, a balloon-borne gamma-ray detector Nicastrin, a protein component of the gamma secretase enzyme complex Nocturnal clitoral tumescence...
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into secreted proteins by the actions of the plasma membrane protein gamma secretase. ApoE may be the signalling ligand responsible for ApoER2's role in...
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Aspartyl proteases: this group includes presenilin, the active subunit of gamma secretase and signal peptide peptidases (SPPs) and SPP-like proteases, which...
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gene. Nicastrin (abbreviated NCT) is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing...
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included programs focused on small molecule inhibitors of beta secretase and gamma secretase, enzymes whose actions are thought to affect the accumulation...
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member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations...
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new cells. Several Notch signaling pathway inhibitors, including the gamma secretase inhibitor LY3056480, are being studied for their potential ability...
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protein Hemoglobin subunit gamma-1; see HBG1 Hemoglobin subunit gamma-2; see HBG2 Gamma secretase Laminin, gamma 1 Laminin, gamma 2 This disambiguation page...
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study, which features PBCAR269A in combination with nirogacestat, a gamma secretase inhibitor. In 2020, the FDA granted fast track designation to PBCAR269A...
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