Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. It belongs to the histone deacetylase class of enzymes responsible...
41 KB (4,587 words) - 20:20, 3 December 2023
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones...
26 KB (2,977 words) - 17:17, 31 October 2024
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone...
31 KB (3,181 words) - 07:12, 12 August 2024
Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene. Histones play a critical role in transcriptional regulation, cell cycle...
17 KB (1,862 words) - 05:58, 6 December 2023
HDAC1 (redirect from Histone deacetylase 1)
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit...
50 KB (5,476 words) - 01:27, 4 January 2024
new antidepressant treatments. Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from histones. Different HDACs play different...
35 KB (4,421 words) - 01:52, 22 November 2024
catalysed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity. Acetylation is the process where an acetyl functional...
58 KB (7,036 words) - 21:48, 28 February 2024
Genetics Histone acetyltransferase Histone deacetylases Histone methyltransferase Histone-modifying enzymes Nucleosome PRMT4 pathway Protamine Histone H1 Youngson...
84 KB (9,582 words) - 21:08, 23 November 2024
Mi-2/NuRD (Nucleosome Remodeling Deacetylase) complex, is a group of associated proteins with both ATP-dependent chromatin remodeling and histone deacetylase...
9 KB (1,064 words) - 00:25, 17 May 2024
HDAC6 (redirect from Histone deacetylase 6)
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit...
15 KB (1,738 words) - 07:16, 11 March 2024
increase the effectiveness of radiotherapy. Histone-modifying enzymes Histone deacetylase (HDAC) Histone methyltransferase (HMT) RNA polymerase control...
53 KB (6,150 words) - 04:41, 26 August 2024
HDAC3 (redirect from Histone deacetylase 3)
Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice. Histones are highly alkaline proteins that package and order DNA...
22 KB (2,493 words) - 10:39, 27 December 2023
cofactor interaction. A specific example is the deacetylation by histone deacetylase 2 (HDACe) was necessary for transrepression of NF-κB. The mechanisms...
57 KB (5,143 words) - 05:47, 15 October 2024
Sodium butyrate (category Histone deacetylase inhibitors)
butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1...
5 KB (436 words) - 13:46, 24 January 2024
Vorinostat (category Histone deacetylase inhibitors)
member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic...
17 KB (1,442 words) - 05:28, 7 May 2024
asthma through the recruitment of histone deacetylase 2(HDAC2) to activated inflammatory genes, thereby reversing the histone acetylation that is involved...
14 KB (1,411 words) - 22:44, 19 November 2024
Trichostatin A (category Histone deacetylase inhibitors)
antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., sirtuins)...
8 KB (690 words) - 12:36, 1 June 2024
Givinostat (category Histone deacetylase inhibitors)
is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a histone deacetylase (HDAC)...
16 KB (1,288 words) - 15:34, 8 July 2024
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. Acetylation of histone core particles modulates chromatin structure and...
7 KB (646 words) - 00:01, 28 November 2023
Pracinostat (category Histone deacetylase inhibitors)
Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor based on hydroxamic acid with potential anti-tumor...
3 KB (253 words) - 22:10, 7 March 2022
properties. Methyl-CpG-binding domain protein 2 has been shown to interact with: GATAD2B, HDAC1, Histone deacetylase 2, MBD3 MIZF, and SIN3A. GRCh38: Ensembl...
12 KB (1,442 words) - 19:46, 3 March 2023
Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene. Histones play a critical role in transcriptional regulation, cell cycle...
20 KB (2,396 words) - 04:11, 8 November 2023
acting as a growth suppressor. The pRb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase...
79 KB (9,502 words) - 07:42, 4 September 2024
against this protein. CHD4 has been shown to interact with HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related. Mutations...
13 KB (1,474 words) - 01:41, 26 March 2024
HDAC4 (category Genes on human chromosome 2)
Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. Histones play a critical role in transcriptional...
19 KB (2,149 words) - 12:19, 11 December 2023
Abexinostat (category Histone deacetylase inhibitors)
types of cancer as well. Abexinostat exerts its effect as a pan-histone deacetylase inhibitor and inhibits RAD51, which is involved in repairing DNA...
9 KB (775 words) - 21:05, 7 July 2024
Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases),...
19 KB (2,214 words) - 12:18, 4 April 2024
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent...
29 KB (3,217 words) - 07:54, 4 November 2024
Romidepsin (category Histone deacetylase inhibitors)
Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis. It is sometimes referred to as depsipeptide...
16 KB (1,455 words) - 03:08, 30 June 2024
Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. Histones play a critical role in transcriptional regulation, cell cycle...
17 KB (2,058 words) - 20:03, 31 March 2024