Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. The...
10 KB (1,104 words) - 02:20, 10 March 2024
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants...
14 KB (1,338 words) - 06:21, 7 October 2024
Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A...
54 KB (6,141 words) - 02:00, 22 September 2024
Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. It...
17 KB (1,672 words) - 02:28, 15 August 2024
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective...
19 KB (1,978 words) - 11:32, 1 May 2024
Orexin-A, also known as hypocretin-1, is a naturally occurring neuropeptide and orexin isoform. The orexinergic nucleus in the lateral hypothalamus is...
5 KB (653 words) - 05:33, 8 December 2023
Cataplexy (section Hypocretin)
destruction of hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of...
22 KB (2,504 words) - 17:02, 19 October 2024
Neuropeptide FF receptor 1 (NPFFR1, FF1R) Neuropeptide FF receptor 2 (NPFFR2, FF2R) Orexin receptor InterPro: IPR000204 Hypocretin (orexin) receptor 1 (HCRTR1...
25 KB (2,172 words) - 01:01, 29 November 2023
Narcolepsy (redirect from Type 1 narcolepsy)
disorder in humans by either modifying the Hypocretin/Orexin receptors or by eliminating this peptide. An orexin deficit caused by the degeneration of hypothalamic...
71 KB (8,194 words) - 01:13, 17 October 2024
Lateral hypothalamus (redirect from Orexin system)
"Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors". Biochemical...
27 KB (3,032 words) - 13:35, 14 November 2023
"Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors". Biochemical...
68 KB (7,780 words) - 04:56, 19 September 2024
CVN45502 (category Orexin antagonists)
CVN45502 is a selective hypocretin (orexin) receptor 1 antagonist. It significantly reduces food intake and body weight in a mouse model of obesity. Although...
4 KB (182 words) - 00:53, 13 September 2024
"Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors". Biochemical...
47 KB (4,256 words) - 15:23, 6 September 2024
Lambe EK, Liu RJ, Aghajanian GK (November 2007). "Schizophrenia, hypocretin (orexin), and the thalamocortical activating system". Schizophrenia Bulletin...
90 KB (9,886 words) - 06:08, 13 September 2024
Suvorexant (category Orexin antagonists)
antagonist of the orexin (hypocretin) receptors OX1 and OX2. These receptors are the biological targets of the endogenous wakefulness-promoting orexin neuropeptides...
94 KB (8,941 words) - 16:56, 16 September 2024
Daridorexant (category Orexin antagonists)
The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Daridorexant...
48 KB (4,078 words) - 11:27, 24 July 2024
Lemborexant (category Orexin antagonists)
The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Lemborexant has...
21 KB (1,687 words) - 09:07, 5 September 2024
Pediatric narcolepsy (section Type 1 narcolepsy)
tuberomammillary nucleus contain orexin receptors, are projected to by orexin cells and are known to be involved in wakefulness. The orexin cells in the lateral hypothalamus...
29 KB (2,856 words) - 20:29, 3 April 2024
Danavorexton (category Orexin receptor agonists)
investigational sleep drugs § Orexin receptor agonists Jacobson LH, Hoyer D, de Lecea L (January 2022). "Hypocretins (orexins): The ultimate translational...
5 KB (301 words) - 01:41, 22 September 2024
sensed by glucose-inhibited neurons in the lateral hypothalamus. These orexin-expressing neurons appear to be hyperpolarised (inhibited) by a glucose-activated...
17 KB (1,778 words) - 16:33, 21 March 2024
Seltorexant (category Orexin antagonists)
investigational sleep drugs § Orexin receptor antagonists Sun Y, Tisdale RK, Kilduff TS (2021). "Hypocretin/Orexin Receptor Pharmacology and Sleep Phases"....
7 KB (498 words) - 08:59, 15 September 2024
named the neuropeptide "hypocretin". Today, "hypocretin" (or HCRT) is used to refer to the gene and transcript, while "orexin" is used to refer to the...
33 KB (2,678 words) - 13:03, 6 July 2024
Amphetamine (redirect from 1-Phenyl-2-Aminopropane)
lack of hypocretin (orexin) of likely an autoimmune origin. In these cases, once the disease is established, the majority of the 70,000 hypocretin-producing...
274 KB (28,846 words) - 10:11, 13 October 2024
of hypocretin-1 to activate the ERK signaling was observed when CB1 and HcrtR1 were co-expressed ... In this study, a higher potency of hypocretin-1 to...
21 KB (2,477 words) - 09:59, 9 February 2024
Firazorexton (category Orexin receptor agonists)
Nonproprietary Name; development code TAK-994) is an experimental orexin 2 (OX2) receptor agonist first described in a 2019 patent filed by Takeda Pharmaceutical...
8 KB (532 words) - 01:59, 22 September 2024
lack of hypocretin (orexin) of likely an autoimmune origin. In these cases, once the disease is established, the majority of the 70,000 hypocretin-producing...
49 KB (6,133 words) - 17:01, 26 July 2024
Tebideutorexant (category Orexin antagonists)
PMC 8055642. PMID 33889031. Jacobson LH, Hoyer D, de Lecea L (May 2022). "Hypocretins (orexins): The ultimate translational neuropeptides". J Intern Med. 291 (5):...
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Neurotransmitter (redirect from Receptors, neurotransmitter)
PMC 3367503. PMID 21729715. Orexin receptor antagonists a new class of sleeping pill, National Sleep Foundation. "Acetylcholine Receptors". Ebi.ac.uk. Retrieved...
94 KB (8,341 words) - 08:44, 9 August 2024
Idiopathic hypersomnia (section Orexin agonists)
Orexin-A has been shown to be strongly wake-promoting in animal models, but it does not cross the blood–brain barrier. Suvorexant, a orexin receptor antagonist...
48 KB (5,193 words) - 06:48, 17 October 2024
"Distribution of orexin/hypocretin in the rat median eminence and pituitary". Brain Research. Molecular Brain Research. 76 (1): 1–6. doi:10.1016/s0169-328x(99)00317-4...
50 KB (4,977 words) - 18:21, 31 August 2024