A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more...

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling...

Janus kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus kinase 3. They are used for the treatment...

Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They...

levels. Ruxolitinib is a Janus kinase inhibitor (JAK inhibitor) with selectivity for subtypes JAK1 and JAK2. Ruxolitinib inhibits dysregulated JAK signaling...

IRS1, IL10RA, PTPN11, STAM2, STAT3, STAT5A, STAT5B, and TNFRSF1A. Janus kinase inhibitor GRCh38: Ensembl release 89: ENSG00000162434 – Ensembl, May 2017...

a medication used for the treatment of alopecia areata. It is a Janus kinase inhibitor selective for JAK1 and JAK2. Deuruxolitinib was approved for medical...

synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. It inhibits signal transduction when the JAK is activated...

unlike biologics. Examples: Tofacitinib Baricitinib JAK inhibitors act by inhibiting Janus Kinases which consequently affect a cascade of enzymes responsible...

It is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly...

the JAK-STAT signal system Janus kinase inhibitor, a medication that inhibits the activity of the Janus kinase enzymes Janus particle, an amphiphilic particle...

juvenile idiopathic arthritis, and ulcerative colitis. It is a janus kinase (JAK) inhibitor, discovered and developed by the National Institutes of Health...

a drug which acts as a Janus kinase inhibitor selective for the JAK2 subtype. It was one of the first Janus kinase inhibitors developed, originally for...

Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene. Janus kinase 3 is a tyrosine kinase that belongs to the janus family...

medication used for the treatment of atopic dermatitis (eczema). It is a Janus kinase inhibitor and it was developed by Pfizer. It is taken by mouth. The most common...

rheumatoid arthritis. It belongs to the class of drugs known as Janus kinase inhibitors (JAK inhibitors). Peficitinib was approved for use in Japan in 2019. Kivitz...

Crisaborole, an inhibitor of PDE-4, is also effective and safe as a topical treatment for mild-to-moderate AD. Ruxolitinib, a Janus kinase inhibitor, has uncertain...

acts as a pan-Janus kinase inhibitor, binding with similar affinity at JAK1, JAK2, JAK3 and TYK2, and also inhibiting spleen tyrosine kinase (SYK). It is...

of cancer. It is an inhibitor of the kinases fms-like tyrosine kinase 3 (FLT3), Janus kinase 2 (JAK2), tropomyosin receptor kinase (trk) A (TrkA), TrkB...

rheumatoid arthritis, alopecia areata, and COVID-19. It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. Baricitinib is approved...

including Paul Changelian to develop the Janus kinase inhibitor tofacitinib. Currently there are nine Janus kinase inhibitors approved by various agencies. O'Shea...

treatment of mild to moderate atopic dermatitis. It is a topical Janus kinase inhibitor. Atopic dermatitis (AD) may be treated with narrowband UVB, which...

treatment of Crohn's disease and ulcerative colitis. Janus kinase inhibitor, a type of Janus kinases-blocking drugs used for cancer therapy. Signal transducing...

Jaktinib is a janus kinase inhibitor under development for myelofibrosis. It is a deuterated-drug analog of momelotinib. Zhang, Yi; Zhou, Hu; Jiang, Zhongxing;...

of treatment; folliculitis is also an occasional complication. Janus kinase inhibitors, previously used in the treatment of cancer and other diseases...

Ivarmacitinib (SHR0302) is a small molecule drug and selective janus kinase 1 (JAK1) inhibitor. It is being developed for ulcerative colitis, eczema, alopecia...

Eli Lilly for treatment of cancer. It is a small molecule JAK2 (Janus kinase) inhibitor, with additional minor inhibition of STAT3. In phase I trial, 16%...

x. PMID 12410698. S2CID 42396825. Qi F, Liu F, Gao L (2021). "Janus Kinase Inhibitors in the Treatment of Vitiligo: A Review". Front Immunol. 12: 790125...

Izencitinib (TD-1473) is a drug which acts as a pan-Janus kinase inhibitor, binding with high affinity at all three subtypes JAK1, JAK2 and JAK3. It is...

who are Janus kinase (JAK) inhibitor naïve or have been treated with ruxolitinib. Fedratinib acts as a competitive inhibitor of protein kinase JAK-2 with...