Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis...
22 KB (2,026 words) - 21:11, 27 March 2024
corneodesmosome-degrading kallikrein family members, especially KLK1, KLK5, and KLK7. Kallikreins are serine proteases. They are packaged within lamellar bodies...
9 KB (878 words) - 17:31, 15 June 2024
been suggested to regulate cell shedding (desquamation) in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular...
9 KB (1,115 words) - 21:12, 27 March 2024
hydrolysis of semenogelin. Desquamation of the skin is likely controlled by KLK5, KLK7 and KLK14, which are expressed in the outermost layer of the epidermis and...
11 KB (1,148 words) - 02:27, 22 June 2024
corneum chymotryptic enzyme, an enzyme class KLK7, a serine protease that in humans is encoded by the KLK7 gene This disambiguation page lists articles...
184 bytes (58 words) - 01:11, 29 December 2019
isolating fukugetin, it was placed with KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, and KLK7 in varying concentrations. This allowed for the analysis of enzyme kinetics...
8 KB (1,086 words) - 13:24, 11 July 2024
distinct aggregates of the secreted components glucosylceramide, cathepsin D, KLK7, KLK8 and corneodesmosin. Transportation of molecules via lamellar bodies...
6 KB (601 words) - 18:16, 13 January 2024
Stratum corneum chymotryptic enzyme (EC 3.4.21.117, kallikrein 7, SCCE, KLK7, PRSS6, hK7) is an enzyme. This enzyme catalyses the following chemical reaction...
3 KB (289 words) - 06:16, 3 December 2023
regulation of desquamation via its ability to selectively inhibit KLK5, KLK7 and KLK14. Recombinant full length LEKTI inhibits the exogenous serine proteases...
10 KB (1,230 words) - 16:10, 5 March 2024
expressed in the skin. Potential endogenous targets of LEKTI include KLK5, KLK7 and KLK14. These enzymes are involved in various aspects of epidermal remodelling...
9 KB (959 words) - 00:35, 15 August 2023
amino acids, its main function is modulating the insulin inhibiting protease KLK7, mainly in adipose tissue. Among other functions, Serpin A12 performs insulin-sensitizing...
9 KB (1,122 words) - 19:31, 25 May 2024
in the epidermis. It is able to the inhibit the chymotryptic activity of KLK7. This gene encodes a member of the alpha-macroglobulin superfamily. The encoded...
4 KB (529 words) - 22:07, 28 November 2023
by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7". The Journal of Investigative Dermatology. 122 (5): 1235–44. doi:10...
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HGNC:6365 Q9Y5K2 8288 KLK5 HGNC:6366 Q9Y337 8289 KLK6 HGNC:6367 Q92876 8290 KLK7 HGNC:6368 P49862 8291 KLK8 HGNC:6369 O60259 8292 KLK9 HGNC:6370 Q9UKQ9 8293...
277 KB (17 words) - 15:46, 9 May 2024
desquamation to occur, corneodesmosomes need to be fully degraded. KLK5 and KLK7 are two serine proteases that degrade corneodesmosomes. LEKTI-2 regulates...
3 KB (317 words) - 12:18, 18 November 2022
epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14. SPINK6 is a member of a gene family cluster located on chromosome...
1 KB (149 words) - 09:54, 17 October 2022
by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7". J. Invest. Dermatol. 122 (5): 1235–44. doi:10.1111/j.0022-202X.2004...
8 KB (916 words) - 22:49, 3 March 2023
and the sixth variant (K5R_I10H_F12W) showed dual-inhibition of KLK5 and KLK7, improved KLK5 inhibition potency, and specificity for KLK5 and KLK14. The...
6 KB (884 words) - 15:59, 11 May 2022
KLK6 Identifiers Aliases KLK6, Bssp, Klk7, PRSS18, PRSS9, SP59, hK6, kallikrein related peptidase 6 External IDs OMIM: 602652; MGI: 1343166; HomoloGene:...
17 KB (1,918 words) - 23:58, 2 December 2023