Microcephalin (MCPH1) is a gene that is expressed during fetal brain development. Certain mutations in MCPH1, when homozygous, cause primary microcephaly—a...

Neanderthal relatives - in this case, microcephalin, an adaptive allele associated with brain development. Microcephalin (MCPH1) regulates brain size, and...

genes ASPM (abnormal spindle-like microcephaly associated) and MCHP1 (microcephalin-1) and their association with the human brain. In this study researchers...

population, suggesting inheritance from Neanderthals. In the case of the Microcephalin D allele, evidence for rapid recent expansion indicated introgression...

suggested that a group of alleles collectively known as haplogroup D of microcephalin, a critical regulatory gene for brain volume, originated from an archaic...

after microcephalin (MCPH1), based on their role in brain size and primary microcephaly syndromes when mutated. In addition to microcephalin, these include...

and animals, including humans, in which it may have introduced the microcephalin D allele. It has been proposed that, historically, introgression with...

the Altai individual showed "no sign of admixture". The variant of microcephalin common outside Africa, suggested to be of Neanderthal origin and responsible...

likewise shows evidence of a selective sweep in African-Americans. Microcephalin GRCh38: Ensembl release 89: ENSG00000066279 – Ensembl, May 2017 GRCm38:...

together, linked to immunity and ultraviolet sensitivity. The gene microcephalin (MCPH1), involved in the development of the brain, likely originated...

control the size of the human brain as it develops. These genes are Microcephalin (MCPH1) and Abnormal Spindle-like Microcephaly (ASPM). The researchers...

(November 2006). "Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage". Proceedings...

disorders such as fragile X syndrome and Rett syndrome. MCPH1 codes for microcephalin, and disorders in this and in ASPM are associated with microcephaly...

frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin". Proceedings of the National Academy of Sciences. 104 (26): 10944–49...

Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens' and 'Microcephalin, a Gene Regulating Brain Size Continues to Evolve Adaptively in Humans"...

doi:10.1038/ng.193. PMC 2684794. PMID 19165922. Introgression and microcephalin FAQ John Hawks [1] Almos PZ, Horváth S, Czibula A, Raskó I, Sipos B...

M, et al. (March 2007). "The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence" (PDF). Human Molecular Genetics...

the disease is thought to be caused by a homozygous mutation in the microcephalin gene. The disease is difficult to reproduce in mouse models because...

studies reviewed, the authors suggest a mediating role of ASPM and microcephalin genes in the relationship between volumes of gray and white matter of...

of variation in two genes related to brain development: an allele of microcephalin that appeared about 37,000 years ago and is common in Europeans and...

ISSN 0968-0004. PMID 10322433. "WDR5 WD repeat domain 5 [Homo sapiens (human)] - Gene - NCBI". "MCPH1 microcephalin 1 [Homo sapiens (human)] - Gene - NCBI"....