A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell. Myofibroblasts are contractile...
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Scar (section Myofibroblast)
contraction is the myofibroblast, which is a specialized contractile fibroblast. These cells express α-smooth muscle actin (α-SMA). The myofibroblasts are absent...
51 KB (5,734 words) - 06:45, 9 August 2024
occurs without myofibroblast involvement. Later, fibroblasts, stimulated by growth factors, differentiate into myofibroblasts. Myofibroblasts, which are similar...
104 KB (11,855 words) - 18:42, 10 July 2024
factors to generate myofibroblasts. Dysregulated transforming growth factor β (TGF-β) signalling in fibroblasts and myofibroblasts has been observed in...
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and compliance, through complex coiling. It has been suggested that myofibroblasts also reside in the lamina propria of several organs. These cells have...
11 KB (1,299 words) - 13:27, 3 December 2023
contribute to basal lamina components in some situations (e.g. subepithelial myofibroblasts in intestine may secrete the α-2 chain-carrying component of the laminin...
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becomes congested from engorged soft tissue. Elsewhere in the body, myofibroblasts of the nipple-areolar complex contract, causing erection of the nipples...
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Saunders/Elsevier. ISBN 978-1-4377-0792-2. Shin D1, Minn KW. (2004). "The effect of myofibroblast on contracture of hypertrophic scar". Plast Reconstr Surg. 113 (2):...
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profile to resemble various other cell types, including macrophages, myofibroblasts, mesenchymal stem cells and osteochondrocytes. Importantly, genetic...
100 KB (11,153 words) - 19:49, 23 July 2024
activates resident Hepatic Stellate Cells (HSCs) into the fibrogenic myofibroblasts that are largely responsible for liver fibrosis. However, whereas TNF...
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apoptosis. CAFs have been found to be abundant in a tumour stroma. Myofibroblasts and fibroblasts make up CAFs. The functions of these CAFs have been...
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infarction. Following injury, fibroblasts can become activated and turn into myofibroblasts – cells which exhibit behaviour somewhere between a fibroblast (generating...
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2 spermatids, 3 spermatocytes, 4 spermatogonia, 5 Sertoli cell, 6 myofibroblasts, 7 Leydig cells, 8 capillaries Identifiers MeSH D007985 FMA 72297 Anatomical...
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This is a list of cells in humans derived from the three embryonic germ layers – ectoderm, mesoderm, and endoderm. Trichocyte Keratinocyte Gonadotrope...
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hepatic stellate cell (HSC) activation, Kupffer cell activation, and myofibroblast activation. Normally, SECs generate nitric oxide, which has several...
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2 spermatids, 3 spermatocytes, 4 spermatogonia, 5 Sertoli cell, 6 myofibroblasts, 7 Leydig cells, 8 capillaries Identifiers MeSH D013093 FMA 72291 Anatomical...
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2. spermatids 3. spermatocytes 4. spermatogonia 5. Sertoli cell 6. myofibroblasts 7. Leydig cells 8. capillaries Details System Reproductive system Location...
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such as ependymoma, glioblastoma and schwannoma. It may also stain myofibroblasts and smooth muscle cells. Furthermore, it may stain nodal epithelial...
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insults that cause inflammation can result in the cells transforming into myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis. The Space...
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new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the core to provide an...
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is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model". Journal...
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deliver signals to surrounding cells and have been shown to regulate myofibroblast differentiation. In melanoma, tumor-derived vesicles can enter lymphatics...
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much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the same type of actin found in smooth muscle, which enables...
12 KB (1,370 words) - 19:11, 17 July 2024
limits fibrosis during wound closure by inducing cell cycle arrest in myofibroblasts once they have fulfilled their function. When these cells have accomplished...
58 KB (6,427 words) - 19:31, 11 July 2024
stellate cells, which increases fibrosis through the production of myofibroblasts, and obstructs hepatic blood flow. In addition, stellate cells secrete...
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contributing to epithelial–mesenchymal transition, and potentially, to myofibroblast differentiation and proliferation. These discoveries suggest that DAMPs...
35 KB (3,558 words) - 10:17, 24 July 2024
as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation. Studies have shown that ACTA2 is associated with TGF-β pathway...
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or structural tissue consisting of a range of cell types (including myofibroblasts, macrophages, lymphocytes and mast cells) and deposited material (such...
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role in TGF-beta1 dependent fibroblast to myofibroblast differentiation. Aberrant persistence of myofibroblasts within tissues can lead to progressive tissue...
60 KB (6,879 words) - 14:26, 16 July 2024
in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular...
25 KB (2,839 words) - 08:50, 18 May 2024