Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial...

When infants are born with certain defects in these proteins, such as nephrin and CD2AP, their kidneys cannot function. People have variations in these...

adult minimal change disease cases exhibited serum autoantibodies against nephrin, a structural protein located in the podocyte slit diaphragm. There has...

slits are covered by a diaphragm that includes the transmembrane protein nephrin. Goodpasture's syndrome is also known as anti-glomerular basement membrane...

been implicated in FSGS. These include: NPHS1, which encodes the protein nephrin that contributes to the filtration barrier; NPHS2, which encodes the protein...

and C-terminus, the latter of which interacts with the cytosolic tail of nephrin, with CD2AP serving as an adaptor. Podocin is localized on the membranes...

slit diaphragms consisting of a mat of proteins, including podocin and nephrin. In addition, foot processes have a negatively charged coat (glycocalyx)...

glomerular disease. CD2AP has been shown to interact with: Cbl gene, NPHS2, Nephrin, and RAB4A. Focal segmental glomerulosclerosis GRCh38: Ensembl release...

syndrome: NPHS1 (Finnish Type): The gene NPHS1 encodes for the protein nephrin. This genetic variant is characterized by severe protein loss in the first...

al., 2003). [supplied by OMIM] KIRREL has been shown to interact with Nephrin and Tight junction protein 1. GRCh38: Ensembl release 89: ENSG00000183853...

expressed in the different compartments of the kidney with podocin and nephrin expressed in glomeruli, Solute carrier family protein SLC22A8 expressed...

humans is encoded by the NPHS2 gene. NPHS2 has been shown to interact with Nephrin and CD2AP. Focal segmental glomerulosclerosis GRCh38: Ensembl release 89:...

epithelial cells also seem to secrete an unknown mediator that reduces nephrin synthesis and distribution.[citation needed] Within membranous glomerulonephritis...

ciliopathies. Another report utilising an isogenic control demonstrated abnormal nephrin localisation in the glomeruli of kidney organoids generated from a patient...

Pollak, MR (February 2021). "Dysregulated Dynein-Mediated Trafficking of Nephrin Causes INF2-related Podocytopathy". Journal of the American Society of...

yet to be discovered. However, mutations in podocyte proteins, such as nephrin, alpha-actinin 4, and podocin, are associated with proteinuria and nephrotic...

β-Catenin, CDH1, CDH2, Collagen, type XVII, alpha 1, Cortactin, FYN, MUC1, Nephrin, PSEN1, PTPN6, PTPRJ, PTPRM, VE-cadherin, YES1, and ZBTB33 δ-Catenin Catenin...

NEPH1 (KIRREL) and NEPH3 (KIRREL2). The NEPH proteins can interact with nephrin and CASK. NEPH2 has been implicated in synapse formation. Disruption of...

congenital nephrotic syndrome is a rare genetic disorder in which the protein nephrin, a component of the glomerular filtration barrier, is altered. Drugs (...

B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS (Jul 2003). "Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular...

with: Beta-catenin, CDH1, Catenin (cadherin-associated protein), alpha 1, Nephrin and Plakoglobin. Cadherin-3 was first described in 1986 by Masatoshi Takeichi's...

Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun. 300 (2): 364–70. doi:10...

Zhang Y, Liang YZ (April 2009). "[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]". Nan Fang Yi Ke da...

KCNJ4 APBA1 ATP2B4 CINAP and TBR1 DLG1 DLG4 F11 receptor ID1 KCNJ12 LIN7A Nephrin Parkin (ligase) RPH3A SDC2 CASK Research Foundation - A non-profit based...

Karl (1998). "Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome". Molecular Cell. 1 (4): 575–582...

et al. (2005). "Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy". Kidney Int...

syndrome). The last project is examining the interactions and pathology of nephrin, a protein found in podocytes. The long-term goal for these three projects...

FYB, FASLG, GNB2L1, GRIN2A, ITK, Janus kinase 2, KHDRBS1, Lck, LKB1, Nephrin, PAG1, PIK3R2, PRKCQ, PTK2B, PTK2, PTPRT UNC119, RICS, SH2D1A, SKAP1, Syk...

Sugimoto H, Kalluri R, Grande JP (Apr 2007). "Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from...

synaptic plasticity and memory formation. Additionally, the protein binds to nephrin and CD2AP within the kidneys, where can help with intracellular signaling...