• Thumbnail for Nucleotide excision repair
    mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA...
    33 KB (3,623 words) - 18:02, 20 August 2024
  • Thumbnail for Base excision repair
    non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing...
    29 KB (3,493 words) - 23:41, 26 October 2024
  • Thumbnail for DNA repair
    mechanisms (base excision repair (BER), nucleotide excision repair (NER), DNA mismatch repair (MMR), homologous recombination repair (HR), non-homologous...
    129 KB (15,900 words) - 22:25, 12 October 2024
  • Thumbnail for ERCC2
    factor IIH (TFIIH) core complex involved in transcription-coupled nucleotide excision repair. Along with XPB, XPD is a part of human transcriptional initiation...
    15 KB (1,846 words) - 16:57, 27 August 2024
  • Thumbnail for Hormesis
    by the DNA nucleotide excision repair (NER) pathway. Lymphocytes from GWI veterans exhibited a significantly elevated level of NER repair. It was suggested...
    32 KB (3,494 words) - 15:39, 15 November 2024
  • Mouse models of nucleotide-excisionrepair syndromes reveal a striking correlation between the degree to which specific DNA repair pathways are compromised...
    97 KB (11,101 words) - 11:45, 3 September 2024
  • (2016). "Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation". Int...
    43 KB (3,768 words) - 09:59, 20 November 2024
  • Thumbnail for ERCC1
    DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease also functions in pathways to repair double-strand breaks in DNA, and in the repair of “crosslink”...
    45 KB (5,372 words) - 16:42, 17 July 2024
  • Thumbnail for Xeroderma pigmentosum
    exposure to UV light is repaired by nucleotide excision repair. In people with xeroderma pigmentosum, this damage is not repaired. As more abnormalities...
    30 KB (3,013 words) - 19:58, 29 October 2024
  • good correlation between nucleotide excision repair capacity and life span. The association between nucleotide excision repair capability and longevity...
    47 KB (5,529 words) - 15:12, 10 November 2024
  • Thumbnail for ERCC4
    are partners during DNA repair. The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease...
    27 KB (3,315 words) - 00:33, 27 January 2024
  • Thumbnail for Nuclease
    base excision repair. These AP sites are removed by AP endonucleases, which effect single strand breaks around the site. Nucleotide excision repair, not...
    22 KB (2,538 words) - 21:26, 7 November 2024
  • Thumbnail for Benzo(a)pyrene
    adducts can be efficiently eliminated from DNA by the process of nucleotide excision repair. Those adducts that are not removed can cause errors during DNA...
    28 KB (2,662 words) - 13:19, 5 November 2024
  • Thumbnail for Pyrimidine dimer
    Pyrimidine dimer (category DNA replication and repair-deficiency disorders)
    typically rectified promptly through DNA repair, such as through photolyase reactivation or nucleotide excision repair, with the latter being prevalent in...
    16 KB (1,941 words) - 17:18, 18 June 2024
  • Thumbnail for XPC (gene)
    DNA adducts in nucleotide excision repair. It is located on chromosome 3. This gene encodes a component of the nucleotide excision repair (NER) pathway...
    16 KB (1,923 words) - 21:51, 26 November 2023
  • roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TFIIH first came to light in 1989 when general...
    11 KB (1,253 words) - 04:38, 28 October 2024
  • Thumbnail for Molecular lesion
    DSB repair occurs through a variety of different pathways and mechanisms in order to correctly repair these errors. Nucleotide excision repair  is one...
    29 KB (3,552 words) - 17:53, 31 October 2024
  • DNA damage (naturally occurring) (category DNA repair)
    Cornerstone of DNA Repair-Targeted Therapies". Oncology. 31 (4): 265–73. PMID 28412778. Schärer OD (October 2013). "Nucleotide excision repair in eukaryotes"...
    81 KB (10,128 words) - 20:51, 11 November 2024
  • Thumbnail for XPB
    in normal basal transcription, transcription coupled repair (TCR), and nucleotide excision repair (NER). Purified XPB has been shown to unwind DNA with...
    17 KB (2,065 words) - 20:47, 6 November 2024
  • Thumbnail for Irofulven
    agents. It inhibits the DNA replication of cells deficient in nucleotide excision repair in culture. Irofulven is an analogue of illudin S, a sesquiterpene...
    11 KB (1,043 words) - 19:39, 26 July 2024
  • Thumbnail for 4-Nitroquinoline 1-oxide
    in animal models. It induces DNA lesions usually corrected by nucleotide excision repair. 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic...
    8 KB (765 words) - 14:06, 26 September 2024
  • bacteria involved in DNA repair by nucleotide excision repair, and it is, therefore, sometimes called an excinuclease. This UvrABC repair process, sometimes...
    5 KB (493 words) - 06:28, 5 September 2024
  • Thumbnail for Aziz Sancar
    for their mechanistic studies of DNA repair. He has made contributions on photolyase and nucleotide excision repair in bacteria that have changed his field...
    28 KB (2,513 words) - 13:38, 30 October 2024
  • DNA polymerase epsilon (category DNA repair)
    leading strand DNA synthesis and nucleotide and base excision repair. Research had conducted to study nucleotide excision repair DNA synthesis by DNA polymerase...
    3 KB (336 words) - 09:50, 4 November 2023
  • Thumbnail for ERCC6
    ERCC6 (section DNA repair)
    DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. The ERCC6 gene is located on the long...
    25 KB (3,274 words) - 22:19, 28 January 2023
  • type). Nucleotide excision repair is a DNA repair mechanism. There are three excision repair pathways: nucleotide excision repair (NER), base excision repair...
    74 KB (8,734 words) - 13:28, 2 November 2024
  • Thumbnail for DNA mismatch repair
    portal Base excision repair Nucleotide excision repair Iyer RR, Pluciennik A, Burdett V, Modrich PL (February 2006). "DNA mismatch repair: functions and...
    35 KB (4,179 words) - 19:39, 22 September 2024
  • Thumbnail for RAD23B
    homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was found to be a component of the protein...
    15 KB (1,848 words) - 13:47, 2 November 2024
  • Thumbnail for XPA
    DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene. Nucleotide excision repair (NER) is a major pathway...
    12 KB (1,437 words) - 23:22, 20 February 2024
  • Thumbnail for Replication protein A
    RPA is required in replication, recombination and repair processes such as nucleotide excision repair and homologous recombination.  It also plays roles...
    7 KB (699 words) - 21:55, 20 September 2024