A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon...
15 KB (1,611 words) - 18:10, 23 May 2024
in mice that have a Plexin-A3 defect. Specifically, axons that are connected to a transient target will retract once the Plexin-A3 receptors are activated...
23 KB (2,972 words) - 02:10, 7 June 2024
Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene. Plexin A1 has been shown to interact with AKT1. GRCh38: Ensembl release 89: ENSG00000114554...
6 KB (703 words) - 22:19, 3 March 2023
induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and...
10 KB (1,298 words) - 06:50, 24 December 2023
Plexin-A4 is a protein that in humans is encoded by the PLXNA4 gene. Plexin A4 binds to neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) and transduces signals...
6 KB (723 words) - 23:59, 3 March 2023
(Sema6D) expressed at the midline, which form a complex that signals to Nr-CAM/Plexin-A1 receptors on crossing RGC axons. Since all vertebrates, even the earliest...
15 KB (1,712 words) - 17:03, 3 July 2024
receptors are called plexins, with neuropilins as their co-receptors in many cases. The main receptors for semaphorins are plexins, which have established...
7 KB (870 words) - 07:16, 16 August 2023
protein ORMDL sphingolipid biosynthesis regulator 3 PLXDC1: encoding protein Plexin domain-containing protein 1 PNPO: encoding enzyme Pyridoxine-5'-phosphate...
26 KB (1,916 words) - 21:48, 21 August 2024
Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene. GRCh38: Ensembl release 89: ENSG00000004399 – Ensembl, May 2017 GRCm38: Ensembl release...
4 KB (453 words) - 23:20, 20 February 2024
the association of L1CAM with neuropilin-1. Neuropilin-1 interacts with Plexin-A proteins to form the Semaphorin-3A receptor complex. Semaphorin-a3A is...
36 KB (3,347 words) - 19:00, 17 April 2024
tyrosine kinase receptors, BMP7, Wnt/dishevelled, EPHB 1–3, Semaphorin/plexin-neuropilin, slit-robo, netrin-frazzled, reelin. Rac, CDC42 and RhoA serve...
25 KB (2,883 words) - 15:18, 26 July 2024
Nakamura F, Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99...
14 KB (1,729 words) - 23:05, 27 March 2024
Plexin-A3 is a protein that in humans is encoded by the PLXNA3 gene. GRCh38: Ensembl release 89: ENSG00000130827 – Ensembl, May 2017 GRCm38: Ensembl release...
4 KB (581 words) - 23:07, 4 September 2022
Plexin domain-containing protein 2 is a protein that in humans is encoded by the PLXDC2 gene. GRCh38: Ensembl release 89: ENSG00000120594 – Ensembl, May...
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also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805) and in viral proteins. CD100 (also called SEMA4D) is...
4 KB (520 words) - 19:02, 6 July 2021
Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM (October 1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99...
16 KB (1,958 words) - 17:08, 8 June 2024
Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene. PLXNB3 has been shown to interact with ARHGEF11. GRCh38: Ensembl release 89: ENSG00000198753...
5 KB (657 words) - 20:03, 3 December 2023
Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene. Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that...
6 KB (739 words) - 11:43, 4 March 2023
RGCs and the midline glia and acts along with Sema6D, mediated via the plexin-A1 receptor. VEGF-A is released from the midline directs RGCs to take a...
29 KB (3,521 words) - 03:39, 17 June 2024
(Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells"...
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Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene. This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins...
6 KB (773 words) - 06:38, 3 June 2024
(Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells"...
13 KB (1,581 words) - 19:22, 27 July 2024
neuropilin 1 and plexin A1. While some of the other class of semaphorins directly bind to plexin receptors, Sema3A does not bind to plexin directly. Instead...
21 KB (2,518 words) - 22:06, 10 December 2023
H (Mar 2003). "Identification and characterization of a novel mouse plexin, plexin-A4". Mechanisms of Development. 120 (3): 385–96. doi:10.1016/S0925-4773(02)00421-5...
26 KB (3,128 words) - 08:14, 18 August 2023
proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based...
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documented to regulate neurogenesis and angiogenesis by complexing with Plexin receptors/class-3 semaphorin ligands and Vascular Endothelial Growth Factor...
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PLEKHS1 encoding protein Pleckstrin homology domain containing S1 PLXDC2: plexin domain-containing protein 2 PRAP1: encoding protein Proline rich acidic...
28 KB (1,967 words) - 02:02, 11 April 2024
Plexin domain-containing protein 1 is a protein that in humans is encoded by the PLXDC1 gene. GRCh38: Ensembl release 89: ENSG00000161381 – Ensembl, May...
3 KB (421 words) - 21:04, 13 October 2022
explored the role of the plexin receptor and the Rho family GTPases in central nervous system development in Drosophila. Plexins are receptors involved...
21 KB (2,326 words) - 15:53, 3 June 2024