A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational...
2 KB (280 words) - 18:15, 6 July 2024
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions...
50 KB (5,683 words) - 22:54, 15 November 2024
Amyloid beta (redirect from Islet amyloid precursor protein)
with Alzheimer's disease. The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield...
44 KB (4,832 words) - 17:41, 17 November 2024
somitogenesis in the embryo. It also has an action on an amyloid precursor protein, which gives its probable role in the pathogenesis of FAD. Homologs...
34 KB (3,741 words) - 12:37, 18 October 2024
(called an intein) is removed from a precursor protein with a ligation of C-terminal and N-terminal external proteins (called exteins) on both sides. The...
31 KB (3,821 words) - 22:43, 17 December 2023
chemical compound preceding another in a metabolic pathway, such as a protein precursor. In 1988, the United Nations Convention Against Illicit Traffic in...
5 KB (495 words) - 19:16, 2 September 2024
Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. BACE2 is a close homolog of BACE1. Cerebral deposition of amyloid...
13 KB (1,651 words) - 08:16, 11 November 2024
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside...
53 KB (6,406 words) - 07:06, 12 November 2024
is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). APP...
31 KB (3,371 words) - 18:54, 31 October 2024
is a large genetic component of AD, with mutations in the amyloid precursor protein (APP), Apolipoprotein E APOE), presenilin 1 (PSEN1), bridging Integrator...
59 KB (6,438 words) - 03:50, 9 December 2024
Amyloid (redirect from Amyloid protein)
named α sheet has been proposed as the toxic constituent of amyloid precursor proteins, but this idea is not widely accepted at present. The name amyloid...
60 KB (6,536 words) - 06:58, 4 November 2024
Proteolysis (redirect from Protein degradation)
conversion of an inactive or non-functional protein to an active one. The precursor to the final functional form of protein is termed proprotein, and these proproteins...
34 KB (4,247 words) - 21:28, 2 November 2024
PEN-2 (category Proteins)
proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). The gamma secretase complex consists of PEN-2, APH-1...
4 KB (406 words) - 03:40, 23 November 2024
Neurodegenerative disease (section Protein misfolding)
Amyloid beta is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that penetrates through the neuron's membrane...
62 KB (6,933 words) - 21:04, 3 December 2024
Amyloidosis (category Protein folding)
mutations in the precursor protein.[medical citation needed] Other forms are due to different diseases causing overabundant or abnormal protein production –...
53 KB (5,423 words) - 15:59, 20 December 2024
a longer protein that is embedded in the cell membrane. Among other roles in the cell, secretases act on the amyloid-beta precursor protein (APP) to cleave...
3 KB (319 words) - 08:23, 29 June 2024
LRP1 (redirect from Low density lipoprotein-related protein 1)
diseases, atherosclerosis, and cancer. The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in...
32 KB (3,450 words) - 20:21, 5 December 2024
motors, the kinesins, has been identified as the amyloid precursor protein (APP), the parent protein that produces the senile plaques found in Alzheimer's...
22 KB (2,622 words) - 22:00, 31 May 2024
important role in generation of amyloid beta (Aβ) from amyloid-beta precursor protein (APP). Accumulation of amyloid beta is associated with the onset of...
25 KB (3,113 words) - 03:36, 23 November 2024
misalignment of broken axon microtubules, as well as tau protein and amyloid precursor protein (APP) deposition. Lesions typically are found in the white...
28 KB (3,073 words) - 13:41, 26 August 2024
Endorphin precursors are primarily produced in the pituitary gland. All three types of endorphins are fragments of the precursor protein proopiomelanocortin...
25 KB (2,604 words) - 15:59, 22 October 2024
Bovine serum albumin (category Blood proteins)
full-length BSA precursor polypeptide is 607 amino acids (AAs) in length. An N-terminal 18-residue signal peptide is cut off from the precursor protein upon secretion...
15 KB (1,488 words) - 21:52, 8 November 2024
transmembrane spanning glycoprotein amyloid-beta precursor protein (APP). Amyloid plaque Aβ protein species ends in residue 40 or 42, but it is suspected...
13 KB (1,704 words) - 11:44, 4 April 2024
misprocessing of amyloid precursor protein (APP). The result of this abnormal processing is the accumulation of fragments of this protein, called amyloid β (Aβ)...
61 KB (7,328 words) - 18:22, 12 August 2024
Growth factor-like domain (category Protein stubs)
within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member...
1 KB (132 words) - 20:57, 11 September 2020
and updating web resources Acute-phase protein, a class of proteins Amyloid-beta precursor protein, a protein Atactic polypropylene, a hot-melt adhesive...
3 KB (399 words) - 22:29, 19 November 2024
precursor protein from the OXT gene. This precursor protein also includes the oxytocin carrier protein neurophysin I. The inactive precursor protein is...
110 KB (12,241 words) - 19:17, 17 December 2024
amyloid-beta precursor protein (APP) and presenilins PSEN1 and PSEN2. Most mutations in the APP and presenilin genes increase the production of a small protein called...
186 KB (19,741 words) - 14:58, 18 December 2024
being evaluated to treat early Alzheimer's disease. It is an amyloid precursor protein antagonist. "Valiltramiprosate - Alzheon". AdisInsight. Springer Nature...
2 KB (77 words) - 08:42, 12 September 2024
TAC1 (category Precursor proteins)
(abbreviated PPT-1, PPT-I, or PPT-A), is a precursor protein that in humans is encoded by the TAC1 gene. The protein has four isoforms—alpha-, beta-, gamma-...
5 KB (652 words) - 18:39, 10 January 2023