The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. It is the receptor for prolactin (PRL)...

autocrine, and paracrine manners through the prolactin receptor and numerous cytokine receptors. Pituitary prolactin secretion is regulated by endocrine neurons...

respectively. Prolactin inhibitors are mainly used to treat hyperprolactinemia (high prolactin levels). Agonists of the dopamine D2 receptor such as bromocriptine...

condition characterized by abnormally high levels of prolactin in the blood. In women, normal prolactin levels average to about 13 ng/mL, while in men, they...

agonist of the prolactin receptor and a weak agonist of the growth hormone receptor. hPL has been found to bind to the prolactin receptor with equal affinity...

system in such a way to increase the production of prolactin; specifically, by blocking the D2 receptor. There is some evidence to suggest that mothers who...

like gastroparesis (delayed gastric emptying). It raises the level of prolactin in the human body and is used off label to induce and promote breast milk...

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR...

A (2004). "Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor α and prolactin receptor expression and increases estrogen...

among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease, and for other indications...

functional interaction with the GH receptor. It appears that, in structure, GH is evolutionarily homologous to prolactin and chorionic somatomammotropin...

Parkinson's disease and ability to suppress prolactin levels, while interactions with serotonin receptors are thought to be principally involved in its...

deficiency in the serum levels of the hypothalamic-pituitary hormone prolactin. Hypoprolactinemia is associated with ovarian dysfunction in women, and...

D2 receptors with nanomolar affinity (Ki = 28.8 nM), where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist...

hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. Serotonin receptors influence various biological...

v t e Galactagogues Prolactin receptor agonists Growth hormone/somatotropin Human placental lactogen Prolactin Prolactin releasers Others Breast development...

pathways activated by the EpoR are common to many other receptors; replacing EpoR with prolactin receptor supports erythroid survival and differentiation in...

Cytokine receptors are receptors that bind to cytokines. In recent years, the cytokine receptors have come to demand the attention of more investigators...

v t e Galactagogues Prolactin receptor agonists Growth hormone/somatotropin Human placental lactogen Prolactin Prolactin releasers Others Breast development...

S2CID 37973363. Khong HK, Kuah MK, Jaya-Ram A, Shu-Chien AC (May 2009). "Prolactin receptor mRNA is upregulated in discus fish (Symphysodon aequifasciata) skin...

; Kim, M.; Zhuang, S.; Chin, Y. E. (2010). "Acetylation modulates prolactin receptor dimerization". Proceedings of the National Academy of Sciences. 107...

D2–ghrelin receptor D2sh–TAAR1 The D2 receptor has been shown to form heterodimers in vitro (and possibly in vivo) with DRD3, DRD5, and 5-HT2A. Prolactin modulator...

the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) and to suppress lactation. Metergoline...

The hypothalamic–pituitary–prolactin axis (HPP axis), also known as the hypothalamic–pituitary–mammary axis or hypothalamic–pituitary–breast axis, is...

to breaks, all of which are associated with increased prolactin secretion. Serotonin receptors: The most important pharmacological function is to compensate...

release and regulates the expression of prolactin through binding to the prolactin-releasing peptide receptor (GPR10). PrRP has 20 amino acids, and is...

with hyperprolactinemia like amenorrhea, infertility, hypogonadism, and prolactin-secreting adenomas. It is also used to prevent ovarian hyperstimulation...

inhibition of GnRH release is poorly understood. It is suspected that the prolactin receptor is expressed on a small subset of GnRH neurons in mice and thus has...

Erythropoietin receptor GM-CSF receptor G-CSF receptor Thrombopoietin receptor Growth hormone receptor Prolactin receptor Leptin receptor Oncostatin M receptor Leukemia...

secretion of oxytocin and to increase the expression of its receptor, the oxytocin receptor, in the brain. In women, a single dose of estradiol has been...