Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein that...
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receptor 2 Protease-activated receptor 3 Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R (June 2001). "Proteinase-activated receptors" (abstract). Pharmacological...
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Rattenholl A, Steinhoff M (September 2008). "Proteinase-activated receptor-2 in the skin: receptor expression, activation and function during health and disease"...
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is mediated by S. aureus serine protease V8 which cleaves proteinase-activated receptor 1 (PAR1) on mouse and human sensory neurons. Targeting PAR1 through...
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acts as a potent and selective antagonist of the thrombin receptor proteinase activated receptor 1 (PAR1). It has anticoagulant, anticonvulsant and antiinflammatory...
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F2RL2 (redirect from Protease activated receptor 3)
(thrombin) receptor-like 2". Hollenberg MD, Compton SJ (2002). "International Union of Pharmacology. XXVIII. Proteinase-activated receptors". Pharmacol...
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platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases". The Journal...
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activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues". Ann. N. Y. Acad. Sci. 1091: 445–59...
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kinase phosphorylates and activates the type 1 receptor kinase that activates a signaling cascade. This leads to the activation of different downstream...
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Granzyme B (redirect from Cytotoxic cell proteinase-1)
can also trigger the release of IL6 and IL8 through activation of PAR1 (Protease activated receptor 1). Cleavage of vitronectin occurs at the RGD integrin...
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ACB87490.1 Reddy, V.B.; et al. (2008). "Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors". J. Neurosci...
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This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. Its malfunction acts in an autosomal dominant...
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Integrin (redirect from Integrin receptor)
are transmembrane receptors that help cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction...
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Cathepsin G (redirect from Chymotrypsin-like proteinase)
Mahrus S, Craik C, Coughlin SR (March 2000). "Cathepsin G activates protease-activated receptor-4 in human platelets". The Journal of Biological Chemistry...
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region. Proteinases binding and cleaving the bait region become bound to α2M. The proteinase–α2M complex is recognised by macrophage receptors and cleared...
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Neutrophil (redirect from Neutrophil activation)
are five (HNA 1–5) sets of neutrophil antigens recognized. The three HNA-1 antigens (a-c) are located on the low affinity Fc-γ receptor IIIb (FCGR3B :CD16b)...
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Proteases in angiogenesis (redirect from Receptor shedding)
an initial step for the activation of specific receptors such as Notch, ErbB-4 and the angiopoietin receptor Tie-1. Notch-1 signaling is essential for...
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Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic...
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and Antibacterial Peptides from Lactobacillus helveticus PR4 Proteinase-Hydrolyzed Caseins of Milk from Six Species". Applied and Environmental...
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lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands...
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Serine (redirect from Alternaria serine proteinase)
SH (Nov 2008). "Mechanosensitive N-methyl-D-aspartate receptors contribute to sensory activation in the rat renal pelvis". Hypertension. 52 (5): 938–944...
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(1997). "Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells". The Journal of Experimental...
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factors, and receptors, for example in the biosynthesis of cholesterol, or the mediation of thrombin signalling through protease-activated receptors. Some enzymes...
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Serpin (section Allosteric activation)
lipoprotein receptor-related protein to different conformational states of the clade E serpins plasminogen activator inhibitor-1 and proteinase nexin-1". The...
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variants can act as a receptor for alpha-2-macroglobulin which can have a role in clearance of alpha-2-macroglobulin/proteinase complex. Proteases may...
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Atrolysin A (redirect from Crotalus atrox alpha-proteinase)
Crotalus atrox metalloendopeptidase a, Crotalus atrox α-proteinase, Crotalus atrox proteinase, bothropasin, and hemorrhagic toxin a The amino acid sequence...
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These biological signals activate receptors on endothelial cells present in pre-existing blood vessels. Second, the activated endothelial cells, also known...
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and bind to the variable region of the beta chain of T-cell receptors (TCRs). Once activated, the T cells release pro-inflammatory cytokines and chemokines...
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cataracts. In most cases an activated TGF-β ligand will initiate the TGF-β signaling cascade as long as TGF-β receptors I and II are within reach, this...
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K.; Ogawa, H. (September 2009). "Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes"....
24 KB (2,752 words) - 11:43, 2 December 2023