Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. It belongs to the TMPRSS family of proteins, whose members are transmembrane...

urine levels of mRNA molecules common to prostate tumors like PCA3 and TMPRSS2 fused to ERG. Several large studies have found that men screened for prostate...

Jahn O, Pöhlmann S (January 2014). "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe...

consequences for cells. Examples of these fusion gene products would be TMPRSS2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing’s sarcoma, and FUS-ERG...

t(8 ; 21)), and TMPRSS2-ERG with an interstitial deletion on chromosome 21, often occurring in prostate cancer. In the case of TMPRSS2-ERG, by disrupting...

spike protein variants that can enhance syncytia formation. The protease TMPRSS2 is essential for syncytia formation. Syncytia can allow the virus to spread...

priming virus's Spike protein to show the protein named "fusion protein" (TMPRSS2 activate SARS-CoV-2 fusion). Exogenous snake venom serine proteases cause...

N-0385 is an experimental small molecule TMPRSS2-inhibitor being investigated for its potential use in the prevention and treatment of COVID-19. N-0385...

entry. Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS‑CoV‑2. The host protein neuropilin 1 (NRP1)...

process also requires priming of the S protein by the host serine protease TMPRSS2, the inhibition of which is under current investigation as a potential...

protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...

protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...

proteases such as cathepsin family and transmembrane protease serine 2 (TMPRSS2) of the host cell. S1 proteins are the most critical components in terms...

pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). For chronic pancreatitis camostat's typical dose is 600 mg daily, for...

protein trefoil factor 3 TIAM1: Rho guanine nucleotide exchange factor TIAM1 TMPRSS2: encoding enzyme transmembrane protease serine 2 TMPRSS3: encoding enzyme...

such as disruption of the tumor suppressor gene PTEN or creation of the TMPRSS2-ERG fusion gene.[citation needed] Chromplexy was originally inferred by...

carboxypeptidase II erbB-3 receptor Early prostate cancer antigen-2 SPINK1 GOLM1 PCA3 TMPRSS2 hPG80 Germ cell tumor NANOG Bladder cancer erbB-3 receptor NMP22 Breast...

17065 TMPO HGNC:11875 P42166 P42167 17066 TMPPE HGNC:33865 Q6ZT21 17067 TMPRSS2 HGNC:11876 O15393 17068 TMPRSS3 HGNC:11877 P57727 17069 TMPRSS4 HGNC:11878...

virus, cell type, and local environment. In SARS-CoV, the serine protease TMPRSS2 is important for this process, with additional contributions from cysteine...

protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...

with enzalutamide, the expression of androgen-dependent genes PSA and TMPRSS2 was down regulated in contrast to bicalutamide where the expression was...

model that express the Androgen receptor splice variant, AR-V7, and the TMPRSS2-ERG gene fusion. The cells have an approximate doubling time of 53 hours...

2020). "New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis". BMC Medicine. 18 (1): 216. doi:10.1186/s12916-020-01673-z...

bioRxiv 10.1101/2020.05.09.086249. Meng, B; et al. (March 2022). "Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity". Nature...

Laxman B, Cao Q, Prensner JR, et al. (January 2008). "Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer". Cancer Research...

identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression". Molecular Endocrinology. 23 (11): 1776–1786. doi:10.1210/me...

protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...

in malignant neoplasms. For example, transmembrane serine protease 2 (TMPRSS2), which is an F-protein-processing enzyme, is often overexpressed in prostate...

the cytoplasmic membrane. Adam17 has similar ACE2 cleavage activity as TMPRSS2, but by forming soluble ACE2, Adam17 may actually have the protective effect...

Pienta KJ, Rubin MA, Chinnaiyan AM (October 2005). "Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer". Science. 310 (5748):...