channel subfamily M member 1 is a protein that in humans is encoded by the TRPM1 gene. The protein encoded by this gene is a member of the transient receptor...
9 KB (1,234 words) - 09:21, 7 March 2022
that both CSNB and leopard complex spotting patterns are linked to the TRPM1 gene. The region on horse chromosome 1 to which the Lp gene has now been...
9 KB (1,073 words) - 02:12, 31 July 2024
when LP is present. LP is an autosomal incomplete dominant mutation in the TRPM1 gene located at horse chromosome 1 (ECA 1). All horses with at least one...
73 KB (7,231 words) - 06:31, 29 July 2024
team mapped the Lp gene to a transient receptor potential channel gene, TRPM1 or Melastatin 1 (MLSN1). The leopard complex allele contains a 1378 base-pair...
24 KB (2,603 words) - 01:18, 10 January 2024
CSNB has been identified in horses and dogs as the result of mutations in TRPM1 (Horse, "LP"), GRM6 (Horse, "CSNB2"), and LRIT3 (Dog, CSNB). Congenital...
34 KB (2,878 words) - 04:07, 28 July 2024
particular interest is the "genetic domestication selection at the horse TRPM1 coat-colour locus" as per the study. Although contemporaneous to Copper...
23 KB (2,196 words) - 15:52, 7 July 2024
to form tetramers. The TRPM family consists of eight different channels, TRPM1–TRPM8. Unlike the TRPC and TRPV sub-families, TRPM subunits do not contain...
7 KB (821 words) - 22:40, 16 July 2024
sulfate is an agonist of the sigma receptor, as well as an activator of the TRPM1 and TRPM3 channels. It may also interact with potassium channels and voltage-gated...
6 KB (370 words) - 18:49, 6 May 2023
indicated that both CSNB and leopard complex spotting patterns are linked to TRPM1. As this disorder also afflicts humans, a researcher and lead author from...
9 KB (858 words) - 22:00, 27 April 2024
split into two major clades, αTRPM and βTRPM. αTRPMs include vertebrate TRPM1, TRPM3, and the "chanzymes" TRPM6 and TRPM7, as well as the only insect...
49 KB (5,517 words) - 22:16, 16 July 2024
TPCN2 TRPA (channel) TRPC TRPC1 TRPC2 TRPC3 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPML TRPN TRPP TRPP3 TRPV TRPV1...
15 KB (1,545 words) - 11:10, 28 December 2023
A6NMA1 17467 TRPC6 HGNC:12338 Q9Y210 17468 TRPC7 HGNC:20754 Q9HCX4 17469 TRPM1 HGNC:7146 Q7Z4N2 17470 TRPM2 HGNC:12339 O94759 17471 TRPM3 HGNC:17992 Q9HCF6...
242 KB (17 words) - 23:17, 27 April 2024
since then living homozygous roan horses have been found. n/n: No roan. TRPM1 (Leopard complex) LP n Appaloosa or Leopard spotting gene. Produces coat...
51 KB (4,824 words) - 16:47, 11 April 2024
Ernest Bailey; Bruce Grahn (August 2008). "Differential Gene Expression of TRPM1, the Potential Cause of Congenital Stationary Night Blindness and Coat Spotting...
92 KB (10,969 words) - 08:04, 16 August 2024
expression of TRP proteins often leads to tumorigenesis, clearly seen in TRPM1. Particularly high levels of TRPV6 in prostate cancer have been noted. Such...
13 KB (1,271 words) - 23:41, 6 March 2024
of voltage gated ion channels. TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7 TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8 TRPV1; TRPV2; TRPV3; TRPV4;...
19 KB (1,692 words) - 03:53, 29 November 2023
"Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma". Cancer Research. 64 (2): 509–16....
43 KB (4,822 words) - 22:18, 10 June 2024
for initiating a signaling cascade that ultimately controls gating of the TRPM1 channel. In human patients, mutations in the GRM6 gene are associated with...
7 KB (868 words) - 09:00, 18 August 2023
610427; CABP4 Night blindness, congenital stationary, type IC; 613216; TRPM1 Night blindness, congenital stationary, X-linked, type 2A; 300071; CACNA1F...
234 KB (18,877 words) - 15:43, 9 May 2024