U.S. Route 400 (US 400) is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 69 (US 69) is a major north–south United States highway in the central United States. When it was first created, it was only 150 miles (241 km)...

U.S. Route 54 (US 54) is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville...

U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western...

U.S. Route 283 is a spur of U.S. Route 83. It currently runs for 731 miles (1,175 km) from Brady, Texas at U.S. Route 87 to Lexington, Nebraska at U.S...

concurrently to . US 31 / US 43 in Columbia I-65 in Columbia U.S. Route 400 U.S. Route 425 U.S. Route 412B in Hindsville, Arkansas U.S. Route 412B in Huntsville...

U.S. Route 259 (US 259, US-259) is a north–south spur of U.S. Route 59 that runs for 250 miles (400 km) through rural areas of northeastern Texas and...

U.S. Route 77 (US 77) is a major north–south United States Numbered Highway which extends for 1,305 miles (2,100 km) in the central United States. As...

U.S. Route 385 (US 385) is a spur of U.S. Route 85 that runs for 1,206 miles (1,941 km) from Deadwood, South Dakota to Big Bend National Park in Texas...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 83 (US 83) is a major north–south United States Numbered Highway that extends 1,885 miles (3,034 km) in the central United States. Only four...

U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S...

U.S. Route 183 (US 183) is a north–south United States highway. The highway's northern terminus is in Presho, South Dakota, at an intersection with Interstate...

U.S. Route 58 (US 58) is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S...

U.S. Route 310 (US 310) is a spur of historic U.S. Route 10, now Interstate 90. It runs for 108 miles (174 km) from Laurel, Montana, to Greybull, Wyoming...

U.S. Route 140 (Pennsylvania "Legislative Route 42") was a U.S. highway connecting Gettysburg, Pennsylvania, to Baltimore, Maryland. The route was deleted...

U.S. Route 281 (US 281) is a north–south United States Numbered Highway. At 1,875 miles (3,018 km) it is the longest continuous three-digit U.S. Route...

U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south United States Numbered Highway in the Eastern United States. Despite encroaching Interstate Highways...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 95 (US 95) is a major north–south United States Highway in the western United States. It travels through the states of Arizona, California...

U.S. Route 68 (US 68) is a United States highway that runs for 560 miles (900 km) from northwest Ohio to Western Kentucky. The highway's western terminus...

U.S. Route 277 (US 277, US-277) is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route...

U.S. Route 50 (US-50) is a major east–west route of the U.S. Highway system, stretching just over 3,000 miles (4,800 km) from Interstate 80 (I-80) in...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Route 169 (US 169) is a north-south U.S highway that currently runs for 966 miles (1,555 km) from the city of Virginia, Minnesota, to Tulsa, Oklahoma...

Georgia State Route 400 (SR 400; commonly known as Georgia 400) is a freeway and state highway in the U.S. state of Georgia serving parts of Metro Atlanta...

U.S. Route 209 (US 209) is a 211.74-mile (340.76 km) long U.S. Highway in the states of Pennsylvania and New York. Although the route is a spur of US 9...

U.S. Route 192 (US 192) is an east–west route of the United States Numbered Highway system in central Florida. It runs 75.04 miles (120.77 km) from U...

U.S. Route 75 is a north–south U.S. Highway that runs 1,239 miles (1,994 km) in the central United States. The highway's northern terminus is located at...