Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide...

mutations. All PI 3-kinases are inhibited by the drugs wortmannin and LY294002 but wortmannin shows better efficiency than LY294002 on the hotspot mutation...

intramolecular aldol reaction in the ring closure step for total synthesis of (+)-Wortmannin by Shigehisa, et al. (Figure 2). Klein, David R. (December 22, 2020)....

edge in osteogenic differentiation. Wortmannin is a PI3K-specific inhibitor, and treatment of cells with Wortmannin in combination with PDGF resulted in...

inhibited by the drugs wortmannin and LY294002, although certain members of the class II PI3K family show decreased sensitivity. Wortmannin shows better efficiency...

BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE 1e7v: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002...

ligand. The formation of these vesicles is sensitive to inhibition by wortmannin[citation needed] The initiation of vesicle formation can be delayed/inhibited...

activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice". FASEB Journal. 18 (15): 1894–96. doi:10...

potent than wortmannin, another well-known PI3 kinase inhibitor. However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly...

C-4 and C-6 of the steroid framework. Members of this family, including wortmannin, are known to be potent, irreversible covalent inhibitors of phosphoinositide...

an anamorph species of fungus in the genus Penicillium which produces wortmannin. MycoBank Straininfo of Penicillium proteolyticum ATCC V. Betina (1993)...

Vitamin H (biotin) Vitamin K (naphthoquinone) Vitamin M (folic acid) Water Wortmannin Xanthophyll Xylose Yellow fluorescent protein Zearalenone Chemical compound...

specific inhibitors were tested: cytochalasin D (depolymerizing agent), wortmannin (Wort), LY-294002 (both are inhibitors of PI3K) and EIPA (5-(N-ethyl-N-isopropyl)...

of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may...

cell carcinoma and endometrial cancer. Sonolisib (codenamed PX-866; a wortmannin derivative) has undergone several phase II trials as a potential treatment...

an IC50 of 0.2 mM and only a low selectivity within the PIKK family. Wortmannin is an irreversible inhibitor of ATM with no selectivity over other related...

Special antibiotics and molecular biology reagents. Anisomycin, Thiolutin, Wortmannin, K252a, Staurosporine, K252C, Bafilomycin, Alamethicin, Leptomycin, A23187...

described in 2007. Aspergillus australensis produces aszonalenins and wortmannins. A. australensis has been cultivated on both Czapek yeast extract agar...

caused OGT to localize to the plasma membrane. Inhibition of PI3K with wortmannin reversed this effect, suggesting dependence on phosphatidylinositol(3...

"Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine". Molecular Cell. 6...

of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin". J. Biol. Chem. 271 (35): 21005–1011. doi:10.1074/jbc.271.35.21005. PMID 8702863...

prolactin cellular response to DNA damage stimulus cellular response to wortmannin mitotic cell cycle cell cycle DNA repair cell differentiation RNA splicing...

"Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine". Molecular Cell. 6...

Meyers R, Cantley LC (February 1997). "Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase". The Journal of Biological...

produce aszonalenins, chromanols, tryptoquivalines, tryptoquivalones, and wortmannins. Samson, R.A.; Visagie, C.M.; Houbraken, J.; Hong, S-B.; Hubka, V.; Klaassen...

asperpentyn, avenaciolide, glabramycin A, B, C, sartoryglabrin A, B, C, and wortmannins. A. neoglaber has been cultivated on both Czapek yeast extract agar (CYA)...

of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not...