ALOX12 (EC 1.13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme...
32 KB (3,928 words) - 09:06, 1 September 2023
consists of 662–711 amino acids. Mammalian LOX genes contain 14 (ALOX5, ALOX12, ALOX15, ALOX15B) or 15 (ALOX12B, ALOXE3) exons with exon/intron boundaries...
32 KB (3,886 words) - 03:28, 23 April 2024
which metabolizes 5-HPETE to leukotrienes. The enzyme 12-lipoxygenase (ALOX12) catalyzes oxidation of arachidonic acid to 12-hydroperoxyeicosatetraenoic...
21 KB (1,900 words) - 21:15, 28 July 2024
acid (i.e. 8,15-DiHETE), and 15-oxo-ETE and 12-lipoxygenase (12-LOX or ALOX12) initiates the metabolism of arachidonic acid to 12-HpETE, 12-HETE, hepoxilins...
84 KB (9,646 words) - 03:37, 12 August 2024
HGNC:428 Q8TCU4 590 ALOX5 HGNC:435 P09917 591 ALOX5AP HGNC:436 P20292 592 ALOX12 HGNC:429 P18054 593 ALOX12B HGNC:430 O75342 594 ALOX15 HGNC:433 P16050 595...
277 KB (17 words) - 23:17, 27 April 2024
12-Hydroxyeicosatetraenoic acid is an eicosanoid metabolite of arachidonic acid made by ALOX12 which stimulates leukocyte chemotaxis through the leukotriene B4 receptor...
65 KB (7,370 words) - 06:10, 19 July 2024
enzymes with 15-lipoxygenase activity which in humans includes ALOX15, ALOX12, aspirin-treated cyclooxygenase 2, and cytochrome P450s of the microsomal...
37 KB (4,357 words) - 04:19, 25 March 2024
include A-967079, HC-030031 and AM-0902. The eicosanoids formed in the ALOX12 (i.e. arachidonate-12-lipoxygnease) pathway of arachidonic acid metabolism...
35 KB (4,048 words) - 22:58, 16 July 2024
lipoxygenases, in distinction to the other three human lipoxygenases (ALOX5, ALOX12, and ALOX15), because they were initially defined as being highly or even...
20 KB (2,593 words) - 04:15, 27 February 2024
made by human and bovine platelets through their 12S-lipoxygenase (i.e. ALOX12) enzyme(s). However, the term 12-HETE is ambiguous in that it has been used...
63 KB (6,987 words) - 10:03, 27 March 2024
(see DNA damage theory of aging). LMNA has been shown to interact with: ALOX12 EMD NARF SREBF1 TMPO ZNF239 SIRT1 GRCh38: Ensembl release 89: ENSG00000160789...
24 KB (2,694 words) - 22:56, 9 April 2024
ALOX5 followed by ALOX15 (or possibly ALOX15B); or c) ALOX5 followed by ALOX12. Cells and, indeed, humans treated with aspirin form the 15R-hydroxy epimer...
66 KB (7,270 words) - 21:47, 16 May 2024
forms a beta-sandwich composed of two β-sheets of four β-strands each. ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC; LIPG; LOXHD1;...
3 KB (295 words) - 21:27, 18 September 2021
reaction, the conversion of 12(S)-HpETE to HxA3 and HxB3, may be catalyzed by ALOX12 as an intrinsic property of the enzyme. Based on gene knockout studies,...
32 KB (3,972 words) - 20:16, 12 July 2024
10-fold weaker than 5(S)-HETE in stimulating cells. 12-Lipoxygenase (i.e. ALOX12) to metabolize 5(S)-HETE to 5(S),12(S)-diHETE. The activity of this product...
48 KB (6,107 words) - 06:42, 13 August 2024
these two products are novel hepoxilins produced by ALOX15 rather than ALOX12, the enzyme responsible for making the various other hepoxilins in humans...
67 KB (7,345 words) - 06:16, 13 August 2024