• Thumbnail for AMP-activated protein kinase
    5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular...
    65 KB (7,147 words) - 05:41, 24 June 2024
  • Thumbnail for Protein kinase A
    5'-AMP-activated protein kinase (AMP-activated protein kinase). Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent...
    27 KB (2,665 words) - 17:03, 6 April 2024
  • Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase...
    3 KB (296 words) - 17:06, 14 September 2023
  • A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses...
    46 KB (5,492 words) - 03:05, 21 June 2024
  • Thumbnail for Adenosine monophosphate
    eukaryotic cell enzyme 5' adenosine monophosphate-activated protein kinase, or AMPK, utilizes AMP for homeostatic energy processes during times of high...
    14 KB (1,255 words) - 07:33, 5 March 2024
  • Thumbnail for Protein kinase, AMP-activated, alpha 1
    5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein encoded by this gene...
    10 KB (1,255 words) - 06:02, 24 June 2024
  • PKCs are activated through the same signal transduction pathway as phospholipase C. On the other hand, atypical (a)PKCs (including protein kinase Mζ and...
    27 KB (2,716 words) - 18:23, 1 August 2024
  • Thumbnail for Protein kinase B
    molecules, including integrin-linked kinase (ILK) and mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2) can also serve as PDK2. Phosphorylation...
    35 KB (3,831 words) - 00:20, 19 July 2024
  • Thumbnail for C-Jun N-terminal kinases
    transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines...
    14 KB (1,626 words) - 20:50, 30 May 2024
  • p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines...
    14 KB (1,385 words) - 10:32, 28 April 2024
  • Thumbnail for Metformin
    (July 2007). "Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration". American Journal of...
    149 KB (14,268 words) - 21:56, 31 July 2024
  • [citation needed] In the MAPK/ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then...
    11 KB (1,128 words) - 19:03, 18 September 2023
  • Thumbnail for HMG-CoA reductase
    decrease in activity of the enzyme is caused by AMP-activated protein kinase, which responds to an increase in AMP concentration, and also to leptin. Since the...
    34 KB (4,113 words) - 16:29, 29 July 2024
  • The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates...
    14 KB (1,447 words) - 09:31, 22 December 2023
  • an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular...
    8 KB (886 words) - 12:46, 31 January 2024
  • Thumbnail for Ribosomal s6 kinase
    kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein...
    5 KB (510 words) - 17:10, 16 September 2021
  • increase in the substrate demand. This leads to an activation of AMP-activated protein kinase (AMPK) as the AMP concentration rises in intracellular fluids and...
    12 KB (1,519 words) - 21:42, 1 August 2024
  • Thumbnail for ATM serine/threonine kinase
    serine/threonine kinase or Ataxia-telangiectasia mutated, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand...
    50 KB (5,639 words) - 20:54, 11 March 2024
  • Thumbnail for G protein-coupled receptor
    domain by protein kinases. Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was...
    82 KB (9,384 words) - 18:56, 11 June 2024
  • Thumbnail for Serine/threonine-specific protein kinase
    A serine/threonine protein kinase (EC 2.7.11.-) is a kinase enzyme, in particular a protein kinase, that phosphorylates the OH group of the amino-acid...
    14 KB (1,210 words) - 13:35, 14 June 2024
  • Thumbnail for CGMP-dependent protein kinase
    cGMP-dependent protein kinase or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number...
    8 KB (825 words) - 21:37, 20 April 2023
  • Thumbnail for Ca2+/calmodulin-dependent protein kinase II
    Ca2+ /calmodulin-dependent protein kinase II (CaM kinase II or CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+ /calmodulin...
    29 KB (3,458 words) - 16:39, 17 March 2024
  • Thumbnail for HL156A
    metformin and a potent oxidative phosphorylation inhibitor and AMP-activated protein kinase activating biguanide. Certain types of cancer cells requires oxidative...
    8 KB (607 words) - 16:20, 17 February 2024
  • GK. In contrast, phosphorylation of GKRP by AMP-activated protein kinase, induced by elevated levels of AMP, reduces its capacity to inactivate GK. A presence...
    15 KB (1,696 words) - 00:07, 20 December 2023
  • Thumbnail for P70-S6 Kinase 1
    Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans...
    17 KB (2,127 words) - 02:01, 8 April 2024
  • Thumbnail for PRKAG2
    5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene. AMP-activated protein kinase (AMPK) is a heterotrimeric...
    9 KB (1,084 words) - 03:22, 25 December 2023
  • Thumbnail for RAF kinase
    the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases. The three RAF kinase family members...
    5 KB (556 words) - 08:06, 3 June 2024
  • Thumbnail for PRKAA2
    5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene. The protein encoded by this gene...
    8 KB (969 words) - 13:51, 23 December 2023
  • Thumbnail for Protein kinase
    including cAMP/cGMP, diacylglycerol, and Ca2+/calmodulin. One very important group of protein kinases are the MAP kinases (acronym from: "mitogen-activated protein...
    15 KB (1,619 words) - 21:11, 21 June 2024
  • Thumbnail for Myosin light-chain kinase
    Myosin light-chain kinase also known as MYLK or MLCK is a serine/threonine-specific protein kinase that phosphorylates a specific myosin light chain,...
    16 KB (1,731 words) - 22:49, 9 January 2024