In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication...

total body clearance is equal to the sum clearance of the substance by each organ (e.g., renal clearance + hepatic clearance + pulmonary clearance = total...

concentrations to calculate doses optimizes therapy in patients with augmented renal clearance. Vancomycin is a branched tricyclic glycosylated nonribosomal...

such as sodium chloride, which are also part of the wastes excreted by the renal system. Over-fertilization with urine or other nitrogen fertilizers can...

called acute renal failure), or when a gradual decline in kidney function, chronic kidney failure, reaches stage 5. Stage 5 chronic renal failure is reached...

2023-04-30. Xiao Q, Zhang H, Wu X, Qu J, Qin L, Wang C (2022). "Augmented Renal Clearance in Severe Infections-An Important Consideration in Vancomycin...

Center, a center founded by electrical engineer Douglas Engelbart Augmented renal clearance, a pharmacokinetic consideration in critically ill persons Australian...

placebo. They utilized serum creatinine, creatinine clearance, and serum urea levels as a measure of renal damage. While in general creatine supplementation...

oral clearance of selegiline is 59.4 ± 43.7 L/min. This is described as very high and as almost 30-fold higher than hepatic blood flow. The renal clearance...

days of dosing. Renal excretion occurs by both glomerular filtration and tubular secretion as evidenced by the high rate of renal clearance (approximately...

December 2011, which include hypocalcaemia and severe renal impairment with a creatinine clearance of less than 35 ml/min. A rare complication that has...

diuretics, can increase blood uric acid levels by interfering with renal clearance. Tumor lysis syndrome, a metabolic complication of certain cancers...

rate, leading to oliguria with a concomitant reduction in creatinine clearance. Renal insufficiency is always progressive with an inferior prognosis, with...

transient) Polydipsia — increased thirst Polyuria — increased urination Renal (kidney) toxicity which may lead to chronic kidney failure, although some...

distribution, clearance) and pharmacodynamics (for example the capacity of mineralocorticoid activity: retention of sodium (Na+) and water; renal physiology)...

excreted unchanged. Renal clearances were reported to be 146–280 ml/min, a plasma clearance of 167 ml/min/1,73m2 and a renal clearance of 125 ml/min/1,73m2...

cortisol on fetal renal function". J Dev Physiol. 10 (1): 85–96. PMID 3351211. Biber J, Murer H, Mohebbi N, Wagner CA (April 2014). "Renal Handling of Phosphate...

that is some three times larger per mass than in humans, a difference augmented by considerably more oxygen bound to hemoglobin and myoglobin of diving...

PMID 11306728. S2CID 39518402. de Jonge MJ, Verweij J (February 2006). "Renal toxicities of chemotherapy". Seminars in Oncology. 33 (1): 68–73. doi:10...

tubule: a novel adaptive mechanism to regulate renal salt and water metabolism Am. J. Physiol. Renal Physiol. 1 July 2008 295:F35-F36 O'Connor A (4 March...

and should be monitored for such. Decreased renal function associated with aging leads to decreased clearance of the drug, resulting in narrow therapeutic...

and anxiety in pediatric populations. However, differences in metabolism, renal function, and total percentage of body water and body fat can influence...

variety of malignancies, including renal cell carcinoma (temsirolimus) and pancreatic cancer, breast cancer, and renal cell carcinoma (everolimus). The...

including baseline weight, waist circumference and BMI, assessments of renal function and liver function, an ECG and other baseline bloods may also be...

1981). "The pharmacokinetics of nortriptyline in patients with chronic renal failure". British Journal of Clinical Pharmacology. 12 (1): 39–45. doi:10...

this change can be explained by increased synaptic release or by reduced clearance of glutamate. ... DHK-sensitive, EAAT2 uptake was not altered by AMPH...

different blocking effect in that its effect was achieved more quickly and augmented a response in the muscle before block. Also, tubocurarine effects were...

which can also be used for examining smoker's macrophages in addition to augmented inflammatory cells in the alveolar lumen. The uptake of tar from cigarettes...

persistence is to reduce the nanoparticles size below the threshold for renal clearance, i.e. ultrasmall nanoparticles (USNPs), meanwhile the maximum light-to-heat...

of an organ such as a hepatic segment, a bronchopulmonary segment or a renal lobe. Excision is the resection of only part of an organ, tissue or other...