The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. It is a 13kbp gene on chromosome 21q22.3 that encodes 545 amino...

in autosomal recessive fashion due to a defect in the AIRE gene (autoimmune regulator), which is located on chromosome 21 and normally confers immune tolerance...

named Promiscuous gene expression (PGE). Aire is a protein called autoimmune regulator (Aire) which is also specifically expressed by mTECs. and its expression...

Autoimmune polyendocrine syndromes (APSs), also called polyglandular autoimmune syndromes (PGASs) or polyendocrine autoimmune syndromes (PASs), are a...

An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy...

thymus tissues. Specifically, the disease results from defects in the autoimmune regulator (AIRE) gene, which stimulates expression of self antigens in the...

Hashimoto's disease, is an autoimmune disease in which the thyroid gland is gradually destroyed. A slightly broader term is autoimmune thyroiditis, identical...

Any disease resulting from this type of immune response is termed an "autoimmune disease". Prominent examples include celiac disease, diabetes mellitus...

mTECs. These cells were shown to uniquely express a protein called autoimmune regulator (Aire), which drives the expression of approximately 40% TRAs, referred...

order to regulate immunosuppression on different cell populations. Autoimmune regulator (AIRE) Autoimmunity Central tolerance Immunity IPEX syndrome Lymphocytes...

Maturation of mTEC leads to expression of high levels of MHCII, CD80, autoimmune regulator Aire and tissue restricted antigens (TRAs). Expression of Cathepsin...

differentiate from medullary thymic epithelial cells after they lose autoimmune regulator (AIRE) expression. This makes them an example of Thymic mimetic cells...

Koop (born 1957), Estonian actress Aire Lepik, Estonian footballer Autoimmune regulator (AIRE), a human gene that is expressed in the thymus Advice on Individual...

receptors as immune-regulating molecules 1997 – Discovery of the autoimmune regulator and the AIRE gene. 2000 – Characterization of M1 and M2 macrophage...

an array of self antigens expressed through the function of the autoimmune regulator (AIRE). The immunoglobulin lambda light chain locus contains protein-coding...

complex of medullary thymic epithelial cells (mTECs). mTECs must be Autoimmune regulator positive (AIRE+) to properly express self-antigens from all tissues...

on their MHC molecules self-peptides, generated mostly by protein Autoimmune regulator, to eliminate T cells with self-reactive TCRs via processes of central...

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma AIRE: encoding protein autoimmune regulator APP: encoding amyloid beta (A4) precursor protein (peptidase nexin-II...

epithelial cells also express the transcription factor labelled autoimmune regulator (AIRE) – this crucial transcription factor allows the medullary epithelial...

Artificial immune system Artificial induction of immunity Autoantibody Autoimmune regulator Autoimmunity Autologous immune enhancement therapy Autophagy Beta-2...

endogenous antigens on MHCI molecules. LNSCs lack expression of the autoimmune regulator, and the production of autoantigens depends on transcription factor...

antigens (PTAs) on their surface. The Transcription factor Aire (autoimmune regulator) that controls the expression of PTAs on mTEC cells in the thymus...

mutation in AIRE (autoimmune regulator). Typical manifestations of APECED are mucocutaneous candidiasis and multiple endocrine autoimmune diseases. APECED...

PMC 3155383. PMID 19963349. Perniola R (2012). "Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral...

protein (Pcl), Trithorax-group proteins like ASH1L, ASH2L and MLL, the autoimmune regulator (AIRE), Mi-2 complex (part of histone deacetylase complex), the co-repressor...

Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints....

Epigenetics of autoimmune disorders is the role that epigenetics (heritable changes that do not involve alterations in DNA sequences) play in autoimmune diseases...

dead link] Ced-3 analog of caspase-9 in Caenorhabditis elegans AIRE Autoimmune Regulator [35] Chou JJ, Matsuo H, Duan H, Wagner G (July 1998). "Solution structure...

mTEC, Thyroid mTEC, Tuft mTEC. Since its discovery in 2001, AIRE (Autoimmune regulator) has been the main focus of studies of thymic (central) immune tolerance...

(Glucocorticoid Modulatory Element Binding) proteins and AIRE-1 (Autoimmune regulator 1) proteins. Sp100 nuclear antigen AIRE DEAF1 GMEB1 GMEB2 Wojciak...