Cyclooxygenase-2 inhibitors (COX-2 inhibitors), also known as coxibs, are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2...

using selective COX-2 inhibitors. Arachidonic acid Cyclooxygenase Cyclooxygenase 1 Cyclooxygenase 2 NSAID COX-2 selective inhibitor Marnett, L. J.; Kalgutkar...

Cyclooxygenase-2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene....

carcinoma Cyclooxygenase-1 Cyclooxygenase-2 Cyclooxygenase-3 (not functional in humans) Discovery and development of COX-2 selective inhibitors PDB: 1CQE​;...

their introduction in 1948. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes). In cells, these enzymes are...

anti-inflammatory drug (NSAID), acting specifically as a relatively selective cyclooxygenase-2 inhibitor. However, the pharmacological profile of nimesulide is peculiar...

and most recently discovered cyclooxygenase (COX3050) isozyme, while the first two to be discovered were COX-1 and COX-2. The COX-3 isozyme is encoded...

Arachidonic acid Cyclooxygenase Cyclooxygenase 2 NSAID Discovery and development of COX-2 selective inhibitors COX-2 selective inhibitor GRCh38: Ensembl...

Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat...

painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. It was patented in 1995. Valdecoxib was manufactured and marketed...

lowering blood pressure. As a result of inhibiting the ACE enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin...

the "Use of the nonselective NSAID diclofenac and the selective cyclooxygenase-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular...

A, Cerovecki A, Goldstein-Müller B, et al. (July 2006). "The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results...

Kleindienst N, Möller HJ, Arolt V, Riedel M (July 2006). "The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results...

2008). "Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man". FASEB Journal. 22 (2): 383–90. doi:10.1096/fj.07-8506com. PMID 17884974...

MF, Silberstein SD (2002). "Hemicrania continua responds to cyclooxygenase-2 inhibitors". Headache. 42 (6): 530–1. doi:10.1046/j.1526-4610.2002.02131...

NF-κB [58]. Another important activity for hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase [59]. Moreover, this species attenuated...

topical formulations of rofecoxib. COX-2 selective inhibitor Discovery and development of cyclooxygenase 2 inhibitors David Graham (epidemiologist) "Vioxx...

inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase,...

A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response...

reversed once the glucocorticoids therapy is stopped. As NSAIDs inhibit cyclooxygenase, the production of thromboxane, a natural coagulator, is inhibited...

FitzGerald GA, Skarke C (October 2013). "GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible...

inhibition the substrate and inhibitor cannot bind to the enzyme at the same time.: 134  This usually results from the inhibitor having an affinity for the...

"JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1". Gastroenterology. 125 (2): 556–71...

A. (2002). Evaluation of Preoperative Administration of the Cyclooxygenase-2 Inhibitor Rofecoxib for the Treatment of Postoperative Pain after Lumbar...

pregnancy or during breastfeeding. Ketorolac works by blocking cyclooxygenase 1 and 2 (COX1 and COX2), thereby decreasing production of prostaglandins...

suicide inhibitors include: Disulfiram, which inhibits the acetaldehyde dehydrogenase enzyme. Aspirin, which inhibits cyclooxygenase 1 and 2 enzymes....

acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect....

NF-κB [58]. Another important activity for hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase [59]. Moreover, this species attenuated...

least two different cyclooxygenase isozymes: COX-1 (PTGS1) and COX-2 (PTGS2). Aspirin is non-selective and irreversibly inhibits both forms (but is weakly...