DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and...

one DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA ends to enable the binding of Artemis protein to one end of each DNA-PKcs. One...

Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...

components of the non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNA ligase IV assembled with topo IIβ and PARP-1....

Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...

forms a complex with DNA-PKcs, which is present in mammals but absent in yeast. Ku is a basket-shaped molecule that slides onto the DNA end and translocates...

recruitment of various NHEJ factors, such as the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), DNA Ligase IV and X-ray cross complementing protein...

combined immunodeficiency (SCIDA). DCLRE1C has been shown to interact with DNA-PKcs. GRCh38: Ensembl release 89: ENSG00000152457 – Ensembl, May 2017 GRCm38:...

Klaus; Lieber, Michael (2005). "The Artemis:DNA-PKcs Endonuclease Cleaves DNA Loops, Flaps, and Gaps". DNA Repair. 4 (7): 845–851. doi:10.1016/j.dnarep...

2004). "Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice". EMBO Reports. 5 (5): 503–09. doi:10.1038/sj.embor.7400127...

there is a DNA test to determine if a given horse is a carrier of the allele. The only known form of horse SCID involves mutation in DNA-PKcs. Unlike SCID...

the 469 kDa DNA-dependent protein kinase (DNA-PKcs) to gain endonuclease activity on hairpins and the 5' and 3' overhangs; the DNA-PKcs phosphorylates...

Esguerra, Z; Watanabe, G; Okitsu, CY; Hsieh, CL; Lieber, MR (April 2020). "DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair...

lamin A, lamin B1, lamin B2, PARP (poly ADP ribose polymerase), and DNA-PKcs (DNA-activated protein kinase). The final result is apoptosis of the cell...

reaction. Although Artemis exhibits 5' → 3' ssDNA exonuclease activity when alone, its complexing with DNA-PKcs allows for endonucleasic processing of the...

enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the...

DNA double-strand breaks by the process of non-homologous end joining and homologous recombination. SIRT6 stabilizes the repair protein DNA-PKcs (DNA-dependent...

(PI3Ks). This protein kinase family includes ATR (ATM- and RAD3-related), DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and mTOR (mammalian target...

P. H.; Williams J. G.; Pears C. J.; Lakin N. D. (2005). "DNA-PKcs-dependent signaling of DNA damage in Dictyostelium discoideum". Curr Biol. 15 (20):...

inhibitors target proteins (PARP family) and kinases (ATM, DNA-PKCs) that are involved in DNA repair. Indirect inhibitors target protein tumor cell signaling...

depends on DNA, it is only functional when localized to the nucleus.[citation needed] The finding that WRN protein interacts with DNA-PKcs and the Ku...

four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure). These enzymes repair the double-strand...

although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PKcs, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK)...

CEBPZ, CDC14A, Cdk1, CFLAR, CHEK1, CCNG1, CREBBP, CREB1, Cyclin H, CDK7, DNA-PKcs, E4F1, EFEMP2, EIF2AK2, ELL, EP300, ERCC6, GNL3, GPS2, GSK3B, HSP90AA1...

DCLRE1C (Artemis) deficiency XLF (protein)/Cernunnos deficiency DNA PKcs deficiency DNA ligase type IV deficiency adenosine deaminase (ADA) deficiency...

C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family...

four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand...

respiratory tract infections. This condition is due to mutations in the DNA-PKcs gene and is inheritable in an autosomal recessive fashion. The gene is...

PARP1. The PARPs have many protein targets at the site of DNA damage. KU protein and DNA-PKcs are both double-stranded break repair components with unknown...

forms a complex with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the full DNA-dependent protein kinase, DNA-PK. Ku is thought to...