DNA (cytosine-5)-methyltransferase 3A (redirect from DNMT3a)
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, a process called...
34 KB (3,924 words) - 10:55, 28 March 2024
intellectual disability syndrome caused by autosomal dominant mutations in the DNMT3A gene. The syndrome was first recognized in 2014 by Katrina Tatton-Brown...
7 KB (569 words) - 23:49, 7 July 2024
(DNMT1, DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a maintenance methyltransferase, DNMT3A and DNMT3B...
58 KB (6,787 words) - 20:17, 9 August 2024
identified in mammals. They are named DNMT1, two isoforms transcribed from the DNMT3a gene: DNMT3a1 and DNMT3a2, and DNMT3b. Recently, another enzyme DNMT3c has...
33 KB (3,598 words) - 17:16, 28 March 2024
of splicing factor genes. Mutation of DNMT3A contributes to development of hematologic malignancies, and DNMT3A-mutated cell lines exhibit transcriptome...
4 KB (364 words) - 02:29, 1 December 2023
family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B. This enzyme is responsible for maintaining DNA methylation...
19 KB (2,381 words) - 11:49, 28 March 2024
methyltransferases (DNMTs). There are 5 DNMTs in humans: DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L, and in algae and fungi 3 more are present (DNMT4, DNMT5...
23 KB (2,630 words) - 08:55, 2 September 2024
(DNMT1, DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a “maintenance” methyltransferase, DNMT3A and DNMT3B...
54 KB (6,343 words) - 14:14, 17 June 2024
splicing factor genes. Mutation of DNMT3A has been demonstrated to contribute to hematologic malignancies, and that DNMT3A-mutated cell lines exhibit transcriptome...
62 KB (7,809 words) - 17:56, 21 May 2024
DNA. There is further crosstalk between DNA methylation carried out by DNMT3A and DNMT3B and histone methylation so that there is a correlation between...
161 KB (18,346 words) - 02:11, 20 August 2024
recommendations. The prognostic importance of other mutated genes (e.g., DNMT3A, IDH1, IDH2) is less clear. Elevated lactate dehydrogenase level were also...
75 KB (7,496 words) - 07:39, 8 October 2024
hematopoiesis. Many of these fall into the categories of epigenetic regulators (DNMT3a, TET2, and ASXL1), signaling proteins (JAK2), spliceosome components (SF3B1...
51 KB (5,805 words) - 04:22, 28 September 2024
cleave unmethylated DNA at all. Mammalian DNA-methyltransferases DNMT1, DNMT3a and DNMT3b catalyze a reaction of DNA methylation. DNMT1 maintains DNA methylation...
5 KB (628 words) - 01:14, 18 June 2024
chromatin and prevent the activation of cryptic start sites. In mammals, DNMT3a and DNMT3b PWWP domain binds to H3K36me3 and the two enzymes are recruited...
114 KB (13,179 words) - 02:59, 22 July 2024
involved in chromatin assembly. ZNF238 has been shown to interact with DNMT3A. GRCh38: Ensembl release 89: ENSG00000179456 – Ensembl, May 2017 GRCm38:...
6 KB (789 words) - 16:20, 22 August 2024
Myc has been shown to interact with: ACTL6A BRCA1 Bcl-2 Cyclin T1 CHD8 DNMT3A EP400 GTF2I HTATIP let-7 MAPK1 MAPK8 MAX MLH1 MYCBP2 MYCBP NMI NFYB NFYC...
57 KB (6,672 words) - 01:42, 9 October 2024
and is mediated through the activity of DNA methyltransferases (DNMTs). DNMT3A and DNMT3B regulate de novo methylation of CpG sites, while DNMT1 maintains...
52 KB (6,235 words) - 15:49, 26 April 2024
second mechanism involves DNMT3A2, a splice-isoform of DNA methyltransferase DNMT3A, which adds methyl groups to cytosines in DNA. This isoform is induced by...
102 KB (11,438 words) - 16:50, 17 July 2024
HGNC:29125 Q9UQ16 4444 DNMBP HGNC:30373 Q6XZF7 4445 DNMT1 HGNC:2976 P26358 4446 DNMT3A HGNC:2978 Q9Y6K1 4447 DNMT3B HGNC:2979 Q9UBC3 4448 DNMT3L HGNC:2980 Q9UJW3...
277 KB (17 words) - 18:34, 6 October 2024
hypermethylation, which may have been induced by the overexpression of DNMT3a. Klotho may be a reliable gene for early detection of methylation changes...
35 KB (3,774 words) - 03:06, 29 September 2024
nucleus, where it can be transcribed. DNMT1 recruits other DNMTs, including DNMT3A and DNMT3B, which, as a complex, recruit HDAC1. This complex adds methyl...
63 KB (7,473 words) - 11:32, 1 September 2024
nicotine dependency. DNMT3B has been shown to interact with: CBX5, DNMT1, DNMT3A, KIF4A, NCAPG, SMC2, SUMO1 and UBE2I. GRCh38: Ensembl release 89: ENSG00000088305...
12 KB (1,443 words) - 11:50, 28 March 2024
L; Shank, K; Martinez, A B V; Rivera, S A; et al. (29 December 2015). "Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic...
63 KB (5,474 words) - 20:32, 25 June 2024
and cancer. The ablation of DNMT3A leads to an increase in HSC self-renewal and a decrease in differentiation. DNMT3A mutations contribute heavily to...
21 KB (2,195 words) - 22:08, 15 September 2024
caused by HBx recruiting the DNA methyltransferase enzymes, DNMT1 and/or DNMT3A, to specific gene loci to alter their methylation levels and gene expression...
56 KB (6,822 words) - 14:04, 6 August 2024
anthracyclines family. Studies have shown that in DNA methyltransferase 3A (DNMT3A) the most frequent mutation is seen at arginine 882 (DNMT3AR882). This mutation...
85 KB (9,593 words) - 19:07, 8 September 2024
the STAT3 gene in 64% of cases and reports of mutations in JAK1, JAK3, DNMT3A, and TP53 genes. The development of BIA-ALCL, it has often been suggested...
42 KB (5,288 words) - 13:09, 4 October 2024
alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle". Environmental Health Perspectives...
150 KB (17,094 words) - 14:34, 1 October 2024
mice, cows, hamsters, and humans. It has also been shown that DNMT1 and DNMT3a decrease with aging and DNMT3b increases. Hypomethylation of DNA can lower...
23 KB (2,575 words) - 03:28, 6 July 2024
site-specific DNA methylation. By fusing the DNMT3a catalytic domain with the dCas9 protein, dCas9-DNMT3a is capable of achieving targeted DNA methylation...
30 KB (3,420 words) - 09:03, 16 August 2024