domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is...

Per-Arnt-Sim (PAS) domain protein 1 (EPAS1). It was found that one single-nucleotide polymorphism (SNP) at EPAS1 shows a 78% frequency difference between...

deeply-diverged from modern Holarctic wolves and dogs has contributed the EPAS1 allele found in both Himalayan wolves and dogs, and this allows them to...

that make Tibetans' bodies well-suited for high-altitudes, including the EPAS1 gene, also referred to as the "super-athlete gene", which regulates the...

continents. Tibetan humans and Tibetan domestic dogs share a genetic mutation in EPAS1, but it has not been seen in Andean humans. Tardigrades live over the entire...

brown eyes. The Denisovan genome also contains a variant region around the EPAS1 gene that in Tibetans assists with adaptation to low oxygen levels at high...

factors that make Tibetan bodies well-suited for high altitudes, including EPAS1, referred to as the "super-athlete gene," that regulates the body's production...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

alleles' high mutation rate. Tibetan people received an advantageous EGLN1 and EPAS1 gene variant, associated with hemoglobin concentration and response to hypoxia...

contributed 39% to the Himalayan wolf's nuclear genome, and contributed the EPAS1 allele which can be found in both Himalayan wolves and dogs which allows...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

and wolves living in the Himalayas and on the Tibetan plateau carry the EPAS1 allele that is associated with high-altitude oxygen adaptation, which has...

ENSG00000163508 T-box Known motif – High-throughput in vitro [202] WTCACACCTH EPAS1 ENSG00000116016 bHLH Known motif – In vivo/Misc source [203] VDACGTGHH ERF...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

Tibetans evolving over 3,000 years to have high proportions of an allele of EPAS1 that is adaptive to high altitudes. Other evolution is related to endemic...

as the Sherpas from Nepal is believed to have inherited an allele called EPAS1, which allows them to breathe easily at high altitudes, from the Denisovans...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

(December 2019). "Vascular Changes in the Retina and Choroid of Patients With EPAS1 Gain-of-Function Mutation Syndrome". JAMA Ophthalmology. 138 (2): 148–155...

For example, in 2010, his research group discovered the variant in the EPAS1 gene that allows Tibetans to live at high altitudes. His research has also...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...

n-Myc MXD4 TCF4 Group C bHLH-PAS AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2 Group D BHLH 2 3 9 Pho4 ID 1 2 3...