Fatty-acid amide hydrolase 1 (FAAH) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide (AEA), an N-acylethanolamine...
33 KB (3,457 words) - 19:03, 3 August 2024
signalling is controlled in part by fatty acid amide hydrolases, which convert the amide to the parent fatty acid. One example of signaling is induced...
2 KB (236 words) - 12:52, 29 January 2023
N-acylethanolamine acid amide hydrolase (NAAA) EC 3.5.1.- is a member of the choloylglycine hydrolase family, a subset of the N-terminal nucleophile hydrolase superfamily...
12 KB (1,466 words) - 07:46, 14 November 2023
Linoleic acid (LA) is an organic compound with the formula HOOC(CH2)7CH=CHCH2CH=CH(CH2)4CH3. Both alkene groups (−CH=CH−) are cis. It is a fatty acid sometimes...
32 KB (2,821 words) - 01:15, 7 August 2024
Hydrolysis (redirect from Amide hydrolysis)
normally. Upon hydrolysis, an amide converts into a carboxylic acid and an amine or ammonia (which in the presence of acid are immediately converted to...
18 KB (2,269 words) - 02:00, 19 June 2024
Oleamide (redirect from Oleic acid amide)
the amide derived from the fatty acid oleic acid. It is a colorless waxy solid and occurs in nature. Sometimes labeled as a fatty acid primary amide (FAPA)...
11 KB (1,013 words) - 04:51, 24 June 2024
Anandamide (category Fatty acid amides)
degraded primarily by the fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into ethanolamine and arachidonic acid. As such, inhibitors of...
22 KB (2,323 words) - 02:41, 9 August 2024
negative affect. She has two mutations, one in the gene encoding fatty acid amide hydrolase (FAAH) and one in the pseudogene FAAH-OUT modulating FAAH expression...
25 KB (2,459 words) - 19:50, 9 August 2024
N-Acylethanolamine (category Fatty acid amides)
An N-acylethanolamine (NAE) is a type of fatty acid amide where one of several types of acyl groups is linked to the nitrogen atom of ethanolamine, and...
185 KB (20,243 words) - 10:50, 3 July 2024
Lipid (redirect from Fatty acyls)
Institute. Fezza F, De Simone C, Amadio D, Maccarrone M (2008). "Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System". Lipids in Health...
71 KB (7,373 words) - 16:15, 8 August 2024
glycan hydrolases, including protein phosphate methylesterase 1, acyloxyacyl hydrolase and sialic acid acetylesterase Some amidases, including fatty acid amide...
3 KB (351 words) - 14:14, 19 March 2023
Firefly luciferin (category Carboxylic acids)
luciferin and modified substrates are fatty acid mimics and have been used to localize fatty acid amide hydrolase (FAAH) in vivo. Firefly luciferin is...
10 KB (960 words) - 13:07, 22 July 2024
on the glial cell and degraded by fatty acid amide hydrolase (FAAH), which cleaves anandamide into arachidonic acid and ethanolamine or monoacylglycerol...
67 KB (7,709 words) - 06:15, 27 May 2024
4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 9.1nM, and 870x selectivity...
2 KB (154 words) - 11:39, 23 January 2023
TRPV1 (redirect from Vanilloid receptor subtype 1)
acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system". The Journal...
57 KB (6,738 words) - 09:20, 7 August 2024
AM404 (category Fatty acid amides)
work on the mechanism of AM404 suggested that the inhibition of fatty acid amide hydrolase (FAAH) by AM404 was responsible for all of its attributed reuptake...
8 KB (639 words) - 06:58, 9 May 2024
hydrolysis of ester- and amide-bond-containing xenobiotics and drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters...
13 KB (1,581 words) - 00:06, 18 March 2023
20-hydroxyeicosatetraenoic acid (20-HETE), N-arachidonoyl dopamine (NADA) and N-oleoyl-dopamine (CID 5282106 from PubChem). Fatty acid amide hydrolase (FAAH), is a...
5 KB (471 words) - 16:44, 30 December 2023
2-Arachidonoylglycerol (category Fatty acid esters)
vitro by monoacylglycerol lipase (MAGL), fatty acid amide hydrolase (FAAH), and the uncharacterized serine hydrolase enzymes ABHD2, ABHD6 and ABHD12. The...
14 KB (1,410 words) - 22:58, 15 July 2023
to soluble epoxide hydrolase, the contribution of mEH to metabolism of beneficial epoxy fatty acids such as Epoxyeicosatrienoic acid is considered minor...
24 KB (2,780 words) - 14:27, 8 December 2023
Biosynthesis (redirect from Biosynthesis of amino acids)
may be located within a single cellular organelle (e.g., mitochondrial fatty acid synthesis pathways), while others involve enzymes that are located across...
61 KB (6,770 words) - 23:10, 5 August 2024
Monoacylglycerol lipase (redirect from EC 3.1.1.23)
enhancer Endocannabinoid reuptake inhibitor Triacylglycerol lipase Fatty acid amide hydrolase Wall EM, Cao J, Chen N, Buller RM, Upton C (December 1997). "A...
10 KB (965 words) - 16:01, 9 August 2024
Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)". Frontiers in Pharmacology...
20 KB (2,187 words) - 19:12, 27 March 2024
N-Acylamides (category Fatty acids)
general class of endogenous fatty acid compounds characterized by a fatty acyl group linked to a primary amine metabolite by an amide bond. Broadly speaking...
23 KB (2,196 words) - 01:50, 11 December 2023
Arachidonoyl serotonin (category Fatty acid amides)
molecule. It was first described in 1998 as being an inhibitor of fatty acid amide hydrolase (FAAH). In 2007, it was shown to have analgesic properties and...
6 KB (442 words) - 04:09, 12 December 2021
Palmitoylethanolamide (category Fatty acid amides)
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, and lipid modulator. A main target of PEA is proposed to be the peroxisome proliferator-activated...
47 KB (5,039 words) - 03:57, 19 July 2024
ABHD6 (redirect from Alpha/beta-Hydrolase domain containing 6)
that they regulate distinct pools of 2-AG in the nervous system. Fatty acid amide hydrolase GRCh38: Ensembl release 89: ENSG00000163686 – Ensembl, May 2017...
3 KB (413 words) - 09:28, 7 March 2022
domains of transmembrane proteins: monoamine oxidases A and B fatty acid amide hydrolase mammalian cytochrome P450 oxidases corticosteroid 11-beta-dehydrogenases...
2 KB (127 words) - 03:11, 7 December 2022
Cyclooxygenase (redirect from EC 1.14.99.1)
acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system" (PDF). The Journal...
16 KB (1,779 words) - 11:08, 3 July 2024