GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including...

selective GABAA agonist with exceptionally high affinity to GABAA-delta receptors, it is also a partial agonist at the GABAA-rho receptor, and so its...

of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled...

modulator of the GABAA-rho receptor. The steroid has been found to possess 82% of the affinity of progesterone for the progesterone receptor in rhesus monkey...

is a neurosteroid and acts as a positive allosteric modulator of the GABAA receptor, the major biological target of the inhibitory neurotransmitter γ-aminobutyric...

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory...

α4β3δ GABAA receptors, low-potency agonist at α1β3γ2, and partial agonist at α4β3γ. Its affinity for this α4-containing subtype of the GABAA receptor is...

(+)-cis-2-Aminomethylcyclopropane carboxylic acid ((+)-CAMP) is an agonist for the GABAA-rho receptor. "AC1LT400 - Compound Summary". PubChem Compound. USA: National Center...

decarboxylation into muscimol, it acts indirectly as a potent GABAA and GABAA-ρ receptor agonist. Unlike muscimol—the principal psychoactive constituent...

Isoguvacine is a GABAA receptor agonist used in scientific research. Gaboxadol Muscimol Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric...

Gabazine (SR-95531) is a drug that acts as an antagonist at GABAA receptors. It is used in scientific research and has no role in medicine, as it would...

been found to be a negative allosteric modulator at the GABAA and GABAA-rho receptors. Of GABAA, it may possibly be selective for the subunits predominantly...

and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. Other agents which may have GABAA receptor antagonism include the antibiotic ciprofloxacin...

1126/science.127.3297.521. PMID 13529017. Rho JM, Donevan SD, Rogawski MA (December 1996). "Direct activation of GABAA receptors by barbiturates in cultured rat...

positive allosteric modulator on GABAA receptors and, at high concentrations, as a direct agonist of the GABAA receptor. It is cleared quickly by the liver...

Isonipecotic acid is a heterocyclic compound which acts as a GABAA receptor partial agonist. It consists of a piperidine ring with a carboxylic acid moiety...

A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel...

derived from the GABAA antagonist bicuculline by a team at Roche. Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive...

GABA's effect in the brain, binding to GABA receptors and inhibiting neuronal signaling. GABAA receptor ligands include: Abecarnil Barbiturates (in high...

allopregnanolone) and also as a negative allosteric modulator of the GABAA-rho receptor. In accordance with the former action, it has been found to possess...

conversion into GABA, progabide behaves as an agonist of the GABAA, GABAB, and GABAA-ρ receptors. Progabide is approved in France for either monotherapy or...

(Z)-4-Amino-2-butenoic acid (CACA, cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABAA-ρ (previously known as GABAC) subtype. cis-4-Aminocrotonic...

Thiomuscimol is a GABAA receptor agonist which is structurally related to muscimol. Lykkeberg, Jytte; Krogsgaard-Larsen, Povl; Garegg, Per J.; Norberg...

and include: GABAA receptors GABAA-ρ receptors The GABAB receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor and its mechanism...

Loreclezole is a sedative and an anticonvulsant which acts as a GABAA receptor positive allosteric modulator. The binding site of loreclezole has been...

electrical activity of neurons by binding to GABAA receptors. There are three main ways the action of the receptor can be classified: relay of signal, amplification...

positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor. Pregnanolone has sedative, anxiolytic...

Liu, H; Yan, Y; Li, Y (2008). "Identification and expression of GABAC receptor in rat testis and spermatozoa". Acta Biochimica et Biophysica Sinica. 40...

as a prodrug of GABA, and therefore as an indirect agonist of the GABA receptors. Progabide Fengabine Triggle DJ (1996). Dictionary of Pharmacological...

dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects. Changes in...