Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from...
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overexpression of Gli1 (Jacob and Briscoe, 2003). Gli1 has been shown to induce the two GLI2 α/β isoforms. Transgenic double homozygous Gli1-/- and Gli2-/-...
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GLI3 (section Interactions with Gli1 and Gli2)
copy-number alterations that contribute to increased conversion of the oncogenes Gli1–3 into transcriptional activators by the Hedgehog signaling pathway are included...
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activation of Shh-GLI1 cascades is caused by STIL's interaction with SUFU, which prevents SUFU from acting as a repressor of GLI1. Normally, GLI1 binds to the...
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complex that recognizes H3K27me3. This occurs in a Gli-dependent manner, as Gli1 and Gli2 are downstream effectors of the Hedgehog signaling pathway. In culture...
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- a fusion between the MALAT1 and GLI1 genes - has been described. This fusion causes over expression of the GLI1 protein and activation of the Sonic...
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different Gli proteins are present, viz. Gli1, Gli2 and Gli3, which are expressed in the neural tube. Mice mutants for Gli1 show normal spinal cord development...
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Greyhound Lines, a North-American bus carrier Volkswagen GLI, an automobile GLI1, GLI2, GLI3, glioma-associated family of transcription factors This disambiguation...
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activation of genes. GANT-61 effectively reduced the DNA-binding affinity of GLI1 and GLI2 in multiple cancer cell lines, including rhabdomyosarcoma, osteosarcoma...
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activation of the GLI transcription factors (Process "5"): the activators Gli1 and Gli2 and the repressor Gli3. The sequence of molecular events that connect...
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C2H2 ZF Known motif – High-throughput in vitro [302] MAATCASDGCNNBBCACT GLI1 ENSG00000111087 C2H2 ZF Known motif – In vivo/Misc source [303] SMCCHCCCA...
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Hedgehog signaling pathway. SMO inhibition causes the transcription factors GLI1 and GLI2 to remain inactive, which prevents the expression of tumor mediating...
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allowing the cell to abruptly switch states at precise Shh concentrations. gli1 and gli2 transcription is activated by Shh, and their gene products act as...
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PMID 11311120. Mao J, Maye P, Kogerman P, et al. (2002). "Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1". J. Biol. Chem. 277 (38):...
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Gendron P, Romeo AA, Morris SJ, et al. (July 2014). "The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation". Nature. 511 (7507):...
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SHH inhibits the Smoothened receptor. Activated smoothened in turn causes Gli1, Gli2, and Gli3 to be translocated into the nucleus where they activate target...
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which a translocational mutation causes the fusion of the ACTB gene over GLI1 in Chromosome 12. Juvenile onset dystonia is a rare degenerative disease...
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HGNC:29514 Q6ZMI3 6284 GLE1 HGNC:4315 Q53GS7 6285 GLG1 HGNC:4316 Q92896 6286 GLI1 HGNC:4317 P08151 6287 GLI2 HGNC:4318 P10070 6288 GLI3 HGNC:4319 P10071 6289...
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Smoothened, leading to activation of the Gli family of transcription factors (GLI1, GLI2, and GLI3). In this context Shh acts as a morphogen - it induces cell...
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part of the hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and hedgehog target genes cannot be transcribed...
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different actions. For example, one study showed that there are proteins called Gli1, Gli2, and Gli3 that affect ventral hindbrain development, and are also required...
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pathway. There are three Gli factors that are essential for limb development: Gli1, Gli2 and Gli3. Without Shh, Gli2 and Gli3 are processed to a repressor form...
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Koga K, Nakashima H, Yao T, Tsuneyoshi M, Tanaka M, Katano M (July 2006). "Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer...
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Nakafuku M, Ishii S (March 1999). "Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3". The Journal of Biological Chemistry. 274 (12):...
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Anguelov M, et al. (Oct 2020). "Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis"...
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"Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis". Annals of Neurology...
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Hedgehog (HH) signaling pathway via interactions with HH transcription factor Gli1 and HH protein receptor Smo, often contributing to tumorigenesis. miR-324-5p's...
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S.; Stephen, Daniel; Joyner, Alexandra L. (October 2002). "Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh...
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Becker, Michael W.; Pei, Shanshan (2014-07-03). "The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation". Nature. 511 (7507):...
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Philpott MP, Quinn AG (15 August 2002). "FOXM1 is a downstream target of Gli1 in basal cell carcinomas". Cancer Res. 62 (16): 4773–80. PMID 12183437. Kalinichenko...
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