Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino...
49 KB (5,773 words) - 16:32, 11 September 2024
Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene...
17 KB (1,819 words) - 16:52, 22 May 2024
GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British multinational pharmaceutical and biotechnology company with headquarters in...
135 KB (12,153 words) - 13:13, 1 October 2024
NP031112) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor. Tideglusib has been evaluated in clinical trials for: Alzheimer's...
6 KB (495 words) - 21:18, 2 September 2024
GlaxoSmithKline (GSK) Pakistan is a Pakistani pharmaceutical company which is a subsidiary of British company GSK. It is the largest pharmaceutical company...
4 KB (276 words) - 11:02, 15 August 2024
storage. Glycogen synthase is directly regulated by glycogen synthase kinase 3 (GSK-3), AMPK, protein kinase A (PKA), and casein kinase 2 (CK2). Each of these...
16 KB (1,741 words) - 06:57, 18 December 2023
The GSK China scandal unfolded when the China division of the global drugmaker GlaxoSmithKline (GSK) admitted to engaging in bribery to promote its products...
39 KB (4,862 words) - 13:34, 27 July 2024
mice produces mania like-behavior. Targets of various treatments such as GSK-3, and ERK1 have also demonstrated mania like behavior in preclinical models...
51 KB (5,619 words) - 04:32, 23 September 2024
protected from degradation by GSK-3. Beta-catenin acts as a co-factor that alters the activity of the transcription factor tcf-3 from repressing to activating...
16 KB (1,871 words) - 15:49, 6 October 2024
Alzheimer's is the hyperphosphorylation of the tau protein by the enzyme GSK-3, which leads to the overproduction of amyloid peptides that cause cell death...
93 KB (9,984 words) - 12:45, 30 September 2024
Sanofi–GSK COVID-19 vaccine sold under the brand name VidPrevtyn Beta, is a COVID-19 vaccine developed by Sanofi Pasteur and GSK. The Sanofi–GSK COVID‑19...
19 KB (1,436 words) - 08:53, 24 September 2024
evolution of GSK-3 isozymes. Eldar-Finkelman is a leading figure in developing novel substrate competitive inhibitors (SCIs) for GSK-3 with significant...
12 KB (1,114 words) - 17:45, 8 February 2023
CHIR99021 is a chemical compound which acts as an inhibitor of the enzyme GSK-3. It has proved useful for applications in molecular biology involving the...
4 KB (311 words) - 08:06, 3 April 2022
glycogen synthase kinase 3 (GSK-3). GSK-3 is responsible for phosphorylating (and thus deactivating) glycogen synthase. When GSK-3 is phosphorylated, it...
31 KB (3,785 words) - 19:26, 2 September 2024
of rapamycin (mTOR) pathway, deactivation of glycogen synthase kinase 3 (GSK-3), and inhibition of the phosphorylation of the eukaryotic elongation factor...
117 KB (11,361 words) - 06:39, 30 September 2024
pp. 141–69. ISBN 978-981-4463-92-8. Doble BW, Woodgett JR (April 2003). "GSK-3: tricks of the trade for a multi-tasking kinase". Journal of Cell Science...
96 KB (9,819 words) - 12:03, 26 July 2024
GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene. The protein encoded by this intronless gene belongs to the GSK-3-binding...
4 KB (481 words) - 11:05, 17 October 2022
phosphorylation of protein kinase B (PKB/Akt) and glycogen synthase kinase 3 (GSK-3). It has also been shown inhibit tyrosine phosphatase (PTPase), PTPases[clarification...
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water content. Mediates enzyme inhibition Phosphorylation of the enzyme GSK-3 by AKT (Protein kinase B) as part of the insulin signaling pathway. Phosphorylation...
67 KB (7,955 words) - 20:50, 29 July 2024
supplements with two inhibitory drugs ("2i"), the MEK inhibitor PD03259010 and GSK-3 inhibitor CHIR99021. ESCs divide very frequently due to a shortened G1 phase...
73 KB (8,680 words) - 00:23, 26 April 2024
000 amino acid residues in length. The exception is the small cardiac novex-3 isoform, which is only 5,604 amino acid residues in length. The following...
45 KB (4,680 words) - 16:38, 13 September 2024
D2 receptor signaling may mediate protein kinase B, arrestin beta 2, and GSK-3 activity, and inhibition of these proteins results in stunting of the hyperlocomotion...
50 KB (5,330 words) - 03:50, 17 June 2024
counter medicines with a 7.3 percent market share in 2022. Haleon was established on 18 July 2022 as a corporate spin-off from GSK. Sir David Lewis is chairman...
15 KB (1,104 words) - 18:19, 6 October 2024
are linked to increased susceptibility. AXIN1 GSK-3 Management of hair loss Wingless localisation element 3 (WLE3) WNT1-inducible-signaling pathway protein...
64 KB (7,430 words) - 15:53, 14 September 2024
that might regulate GSK-3: GBP (GSK-3 Binding Protein) and Dishevelled. The current model is that these act together to inhibit GSK-3 activity. Dishevelled...
33 KB (5,170 words) - 20:53, 16 September 2024
Respiratory syncytial virus vaccine (category Drugs developed by GSK plc)
and causes 160,000 deaths worldwide each year. The RSV vaccines Arexvy (GSK), Abrysvo (Pfizer), and Mresvia (Moderna) are approved for medical use in...
52 KB (4,072 words) - 05:37, 6 October 2024
multinational pharmaceutical, biologics, and vaccines manufacturing company GSK. Adartrel (ropinirole hydrochloride) Advair (salmeterol, fluticasone propionate)...
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transporter 4 (GLUT4) to the plasma membrane. Glycogen synthase kinase 3 (GSK-3) could be inhibited upon phosphorylation by Akt, which results in increase...
35 KB (3,831 words) - 18:08, 20 August 2024
phosphorylation of serine 262 and 356, which in turn leads to activate other kinases (GSK-3 and CDK5) that cause disease-associated phosphoepitopes. The degree of toxicity...
55 KB (6,241 words) - 00:08, 3 October 2024
Pulaski L, et al. (August 2008). "Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells"...
33 KB (3,930 words) - 21:04, 3 September 2024