dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation...

acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid...

mutations (mostly in IDH1) occurs in about 80% of low grade gliomas and secondary high-grade gliomas. Wang et al. pointed out that IDH1 and IDH2 mutant cells...

glioma. Vorasidenib acts to inhibit the enzymes isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2). The most common adverse reactions...

Because the incidence of IDH1/2 mutations increases as the disease malignancy increases, these findings together suggest that IDH1/2 mutations are important...

acute myeloid leukemia with a susceptible IDH1 mutation. Olutasidenib is an isocitrate dehydrogenase-1 (IDH1) inhibitor. It is taken by mouth. The most...

therapy. Astrocytomas carry a mutation in IDH1 or IDH2, whereas this mutation is not present in glioblastoma. Thus, IDH1 and IDH2 mutations are a useful tool...

cholangiocarcinoma. It is a small molecule inhibitor of isocitrate dehydrogenase-1 (IDH1), which is mutated in several forms of cancer. Ivosidenib is an isocitrate...

bone neoplasm. Cases in patients with Ollier disease has shown a link to IDH1, IDH2, and PTH1R gene mutations. Currently, there are no forms of treatment...

these tumors become more dependent on glutamate due to mutations in the gene IDH1. Glutamate is the most abundant excitatory neurotransmitter in the vertebrate...

known as 2-hydroxyglutaric aciduria. Mutations in isocitrate dehydrogenase (IDH1 and IDH2), which frequently occur in glioma and AML, produce D-2-hydroxyglutarate...

mutations include in the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation of a novel oncometabolite, D-2-hydroxyglutarate...

tissue types with IDH1/2 mutations show improved responses to radiation and chemotherapy. Inhibitors of the neomorphic activity of mutant IDH1 and IDH2 are...

"Oligodendroglioma, IDH-mutant, and 1p/19q-codeleted", and requires the presence of IDH1 or IDH2 mutations and the codeletion of chromosome 1p and 19q arms. Interestingly...

Fitim; Pollock, Robin; O'Donnell, Paul; Grigoriadis, Anita (Jul 2011). "IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central...

advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test. Durvalumab, (Imfinzi) is an...

-degib hedgehog signaling pathway inhibitors vismodegib, sonidegib -denib IDH1 and IDH2 inhibitors enasidenib, ivosidenib -lisib Phosphatidylinositol 3-kinase...

spectroscopy (MRS) has been shown to be a noninvasive procedure. The presence of IDH1 or IDH2 mutations was linked to the detection of this oncometabolite 100...

promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft". Oncotarget. 4 (10): 1737–47. doi:10.18632/oncotarget...

tumors belong to the proneural subgroup and were tightly associated with IDH1 somatic mutations. TCGA reported on mRNA expression, microRNA expression...

dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1". Bioorganic & Medicinal Chemistry. 36. doi:10.1016/j.bmc.2021.116095. "Tomatillo:...

the presence or absence of a targeted protein via staining. Mutations in IDH1 and IDH2 genes are commonly found in low-grade gliomas Loss of both IDH genes...

apparent. Maffucci syndrome is most commonly caused by mutations in the IDH1 or IDH2 gene. In Ollier's disease, isolated enchondromas are present without...

the TCA cycle of cancer cells by inhibiting isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), respectively. Ivosidenib is specific...

patients. Importantly, TET2 is mutated in a mutually exclusive manner with WT1, IDH1, and IDH2. TET2 can be recruited by WT1, a sequence-specific zinc finger...

initial treatment with for example BCL2-inhibitors, FLT3-inhibitors, or IDH1/2-inhibitors, may kill leukemic cells. However, pre-leukemic clones may survive...

with tumors harboring additional activating molecular alterations (e.g., IDH1/2 mutations, FGFR mutations) or with a known or suspected diagnosis of neurofibromatosis...

adult patients with relapsed or refractory acute myeloid leukemia with an IDH1 mutation. In November 2019, Agios announced an underwritten public offering...

(2014). "The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone". Neuro-Oncology...

the lowest risk of progression, while splicing factor genes, JAK2, TP53, IDH1, IDH2, FLT3, and RUNX1 have the highest risk. The clonal hematopoiesis risk...