ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has four discrete protein domains. The N-terminal Broad complex, Tramtrack...
17 KB (1,958 words) - 17:09, 18 February 2024
like-ECH-associated protein 1 (KEAP1) and Cullin 3, which degrade NRF2 by ubiquitination. Cullin 3 ubiquitinates NRF2, while Keap1 is a substrate adaptor protein...
29 KB (3,402 words) - 07:08, 20 May 2024
Itaconic acid (section Inactivate KEAP1)
parent and other cells as detailed elsewhere (see SUCNR1 and succinic acid). KEAP1 (i.e., Kelch-like ECH-associated protein 1) resides in the cytoplasm of...
95 KB (11,779 words) - 02:34, 19 August 2024
caloric restriction) induction of NQO1 is mediated solely through the Keap1/Nrf2/ARE. Keap1 acts as the sensor which loses its ability to target Nrf2 for degradation...
28 KB (3,419 words) - 11:08, 6 April 2024
STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1". The Journal of Biological Chemistry. 285 (44): 33747–33755. doi:10.1074/jbc...
2 KB (170 words) - 06:18, 28 June 2024
KBTBD10; KBTBD11; KBTBD2; KBTBD3; KBTBD4; KBTBD5; KBTBD6; KBTBD7; KBTBD8; KEAP1; KIAA1900; KLHDC1; KLHDC2; KLHDC3; KLHDC4; KLHDC5; KLHDC6; KLHDC7A; KLHDC7B;...
5 KB (531 words) - 17:36, 18 February 2024
(blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta)...
9 KB (1,081 words) - 03:24, 12 December 2020
(blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta)...
17 KB (1,829 words) - 04:27, 4 January 2024
genes such as TP53 (mutated in 81% of cases), MLL2 (20%), CDKN2A (15%), KEAP1 (12%) and PTEN (8%). Recurrent loss-of-function mutations have been observed...
14 KB (1,563 words) - 14:58, 30 October 2023
stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249: 114411...
20 KB (3,352 words) - 18:22, 30 September 2024
inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%). The World Health Organization classification of lung tumors recognizes...
3 KB (232 words) - 04:56, 19 May 2024
has been described. Other genes involved affected by this mutation are Keap1, Nrf2 and HMOX1. The diagnosis is made either by testing of the fumarate...
19 KB (2,010 words) - 00:20, 2 August 2024
phosphorylated, the binding affinity between protein complex p62 and the protein Keap1 is strengthened, which is linked to stress response. When serine 337 is...
67 KB (7,955 words) - 20:50, 29 July 2024
RhoBTB2. CUL3 has been shown to interact with: CAND1, Cyclin E1, DCUN1D1, KEAP1, and KLHL12. GRCh38: Ensembl release 89: ENSG00000036257 – Ensembl, May...
20 KB (2,380 words) - 07:40, 8 October 2024
herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway". Scientific Reports. 7 (1): 11551. Bibcode:2017NatSR...
6 KB (497 words) - 04:56, 3 November 2022
genes, including TP53 (mutated in 46% of cases), EGFR (27%), KRAS (32%), KEAP1, STK11 and NF1. EGFR and KRAS mutations tend to appear in a mutually exclusive...
42 KB (4,603 words) - 02:26, 2 September 2024
Tetsuro; Siow, Richard CM (2009). "Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: Protection afforded by dietary...
45 KB (4,451 words) - 16:57, 22 September 2024
HGNC:25840 Q8N371 8108 KDR HGNC:6307 P35968 8109 KDSR HGNC:4021 Q06136 8110 KEAP1 HGNC:23177 Q14145 8111 KEL HGNC:6308 P23276 8112 KERA HGNC:6309 O60938 8113...
277 KB (17 words) - 18:41, 6 October 2024
normal conditions the Nrf2 is bound to Kelch-like ECH associated protein 1 (Keap1) in its inactive form. With the uptake of arsenic within cells and the subsequent...
46 KB (5,345 words) - 19:59, 17 August 2024
stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249: 114411...
89 KB (11,287 words) - 13:51, 5 August 2024
Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1". Molecular and Cellular Biology. 35 (14): 2385–2399. doi:10.1128/MCB.00087-15...
183 KB (12,460 words) - 13:46, 23 September 2024
the sulfur residues in the KEAP1 component of the KEAP1-NFE2L2 protein complex in the cytosol of cells. This negates KEAP1's ability to bind NFE2L2; in...
67 KB (7,270 words) - 19:22, 23 September 2024
stress leads to conformational changes in KEAP1 that repress degradation of NRF2. O-GlcNAc modification of KEAP1 at S104 is required for efficient ubiquitination...
108 KB (12,376 words) - 16:09, 30 March 2024
placebo-treated patients was similar. Bardoxolone methyl is an activator of the KEAP1-Nrf2 pathway in mice. Bardoxolone methyl also inhibits the pro-inflammatory...
9 KB (947 words) - 13:48, 7 November 2023
IFT140, IFT172, IFT80, IQWD1, KATNB1, KIAA1336, KIF21A, KIF21B, KM-PA-2, KEAP1, LLGL1, LLGL2, LRBA, LRRK1, LRRK2, LRWD1, LYST, MAPKBP1, MED16, MORG1, NBEA...
13 KB (958 words) - 04:46, 26 August 2024
malignancy. Certain cancers contain somatic mutations in NRF2(NFE2L2) or KEAP1 that cause constitutive activation of Nrf2 and promote cell proliferation...
25 KB (3,041 words) - 23:52, 24 January 2024
Zhang Y, Zhou Q (October 2011). "MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism". Breast Cancer Research and Treatment. 129 (3): 983–91...
11 KB (1,341 words) - 13:00, 8 August 2024
(September 2008). "Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy". Proceedings of the National Academy...
37 KB (4,261 words) - 18:28, 15 September 2024
effect of this inhibition is to inhibit and/or refers inflammation. KEAP1: cytosolic KEAP1 serves to promote the degradation of Nrf2 by proteasomes thereby...
23 KB (3,059 words) - 16:19, 5 November 2023
Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M (Jan 1999). "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2...
10 KB (1,302 words) - 02:40, 5 October 2023