the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead...

Kassem M (March 2010). "Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin". Journal of Bone and...

imperfecta COLIA2 Autosomal recessive Osteoporosis pseudoglioma syndrome LRP5 Autosomal recessive Osteopetrosis TCIRGI Autosomal recessive Camurati-Engelmann...

that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway...

This condition is caused by autosomal recessive missense mutations in the LRP5 gene, located in the long arm of chromosome 11. This gene normally provides...

specifically more than any of the others. In the body, sclerostin binds to the LRP5 and LRP6 receptors, resulting in inhibition of the Wnt signaling pathway...

it to the proteasome to be digested. However, as soon as Wnt binds Fz and LRP5/6, the destruction complex function becomes disrupted. This is due to Wnt...

Name OMIM Gene OPTA1 607634 LRP5 receptor OPTA2 166600 CLCN7 chloride channel OPTB1 259700 TCIRG1 ATPase OPTB2 259710 RANKL OPTB3 259730 CA2 (renal tubular...

LDLR; LDLRAD2; LDLRAD3; LRP1; LRP10; LRP11; LRP12; LRP1B; LRP2; LRP3; LRP4; LRP5; LRP6; LRP8; MAMDC4; MFRP; PRSS7; RXFP1; RXFP2; SORL1; SPINT1; SSPO; ST14;...

are a group of proteins. They include: LRP1 LRP1B LRP2 (megalin) LRP3 LRP4 LRP5 LRP6 LRP8, apolipoprotein e receptor LRP10 LRP11 LRP12 LRPAP1 (low density...

antagonist. More recently, sclerostin has been identified as binding to LRP5/6 receptors and inhibiting the Wnt signaling pathway. The inhibition of the...

LRP5 gene. It is characterized by increased bone density and benign bony structures on the palate. Worth syndrome is caused by a mutation in the LRP5...

Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, et al. (November 2008). "Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum"...

VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, et al. (Nov 2008). "Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum"...

sclerostin, a secreted protein that inhibits bone formation by binding to LRP5/LRP6 coreceptors and blunting Wnt signaling. Sclerostin, the product of the...

11p15.5 INS-VNTR IDDM3 15q26 D15S107 IDDM4 11q13 MDU1, ZFM1, RT6, FADD, LRP5 IDDM5 6q25 ESR, MnSOD IDDM6 18q12-q21 D18S487, D18S64, JK (Kidd locus) IDDM7...

co-receptor-related disorders occur due to mutations in the receptor's coding gene. LRP5 (low-density lipoprotein receptor-related protein 5) acts as a co-receptor...

been shown to interact with: APC, CTNNB1, CSNK1E, CSNK1A1, DVL1, GSK3B, LRP5, MAP3K1, PPP2R5A, RNF43, and TSC2. GRCh38: Ensembl release 89: ENSG00000103126...

morphogenesis response to retinoic acid negative regulation of Wnt-Frizzled-LRP5/6 complex assembly positive regulation of heart induction by negative regulation...

protein 1 (DKK1). DKK proteins inhibit the Wnt signaling pathway coreceptors LRP5 and LRP6. They bind with high affinity as ligands to KREMEN1 and KREMEN2...

integrins,[excessive citations] Toll-like receptors (TLRs), Wnt co-receptors LRP5/6, the platelet receptor for the von Willebrand factor, and the latent TGFβ...

activity. Importantly, the cytoplasmic segments of the Frizzled-associated LRP5 and LRP6 proteins contain GSK3 pseudo-substrate sequences (Pro-Pro-Pro-Ser-Pro-x-Ser)...

HGNC:25434 Q9P2M1 8866 LRP3 HGNC:6695 O75074 8867 LRP4 HGNC:6696 O75096 8868 LRP5 HGNC:6697 O75197 8869 LRP6 HGNC:6698 O75581 8870 LRP8 HGNC:6700 Q14114 8871...

non-canonical. The canonical signaling involves binding of Wnt to Frizzled and LRP5 co-receptor, leading to GSK3 phosphorylation and inhibition of β-catenin...

Oculodentodigital dysplasia (ODD) CPLANE1 AR Orofaciodigital syndrome type VI LRP5 AR Osteoporosis-pseudoglioma syndrome PAX2 AD Papillorenal syndrome ATOH7...

signaling, but upon the binding of a Wnt ligand with a frizzled receptor and Lrp5/6 the 𝜷-catenin signaling molecule is no longer degraded. Instead, it interacts...

membrane, providing a site for Axin and GSK3β to bind and phosphorylate LRP5/6 (transmembrane low-density lipoprotein receptor-related protein), preventing...

et al. (2008). "Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation". J. Cell Biol. 182 (5): 865–72. doi:10.1083/jcb.200803147...

lumen extracellular region cell surface extracellular exosome Wnt-Frizzled-LRP5/6 complex early endosome membrane plasma membrane Golgi lumen presynapse...

PMID 12477932. Hsieh JC, Lee L, Zhang L, et al. (2003). "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity". Cell...