A lactam is a cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions. The term is a portmanteau of the words lactone...
6 KB (470 words) - 05:54, 14 August 2024
β-lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a beta-lactam ring in their chemical structure. This includes penicillin derivatives...
34 KB (3,708 words) - 13:18, 19 August 2024
A beta-lactam (β-lactam) ring is a four-membered lactam. A lactam is a cyclic amide, and beta-lactams are named so because the nitrogen atom is attached...
11 KB (1,182 words) - 17:34, 24 January 2024
Beta-lactamase (redirect from Beta-lactam hydrolase)
a four-atom ring known as a beta-lactam (β-lactam) ring. Through hydrolysis, the enzyme lactamase breaks the β-lactam ring open, deactivating the molecule's...
53 KB (6,263 words) - 14:38, 30 May 2024
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from Penicillium moulds, principally P. chrysogenum and P. rubens....
98 KB (10,646 words) - 23:48, 3 August 2024
The cephalosporins (sg. /ˌsɛfələˈspɔːrɪn, ˌkɛ-, -loʊ-/) are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously...
37 KB (2,502 words) - 04:47, 10 August 2024
This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class. Antibiotics are listed...
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The Ojima lactam is an organic compound of some importance in the commercial production of Taxol. This lactam was first synthesized by Iwao Ojima. The...
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to beta-lactam antibiotics. In bacterial resistance to beta-lactam antibiotics, the bacteria have beta-lactamase which degrade the beta-lactam rings, rendering...
16 KB (1,696 words) - 15:55, 25 July 2024
bacteria by disrupting the growth of the bacterial cell wall. Cefalexin is a β-lactam antibiotic within the class of first-generation cephalosporins. It works...
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Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined...
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and breastfeeding does not appear to be harmful. Amoxicillin is in the β-lactam family of antibiotics. Amoxicillin was discovered in 1958 and came into...
44 KB (3,947 words) - 22:37, 15 August 2024
horizontal gene transfer) a multiple drug resistance to beta-lactam antibiotics. Beta-lactam (β-lactam) antibiotics are a broad-spectrum group that include some...
106 KB (12,066 words) - 17:53, 20 August 2024
2-Pyrrolidone (redirect from Γ-lactam)
butyrolactam, is an organic compound consisting of a 5-membered lactam, making it the simplest γ-lactam. It is a colorless liquid that is miscible with water and...
6 KB (413 words) - 13:37, 14 July 2024
Vince lactam is the commercial name given to the bicyclic molecule γ-lactam 2-azabicyclo[2.2.1]hept-5-en-3-one. This lactam is a versatile chemical intermediate...
6 KB (472 words) - 00:12, 15 September 2021
allergic reactions including anaphylaxis. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Use in...
30 KB (2,683 words) - 00:35, 25 May 2024
2-Piperidinone (redirect from Δ-lactam)
ruthenium complexes, The compound, a colorless solid, is classified as a lactam. It is the monomer of nylon 5, a polyamide: n (CH2)4CONH → [HN(CH2)4CO)]n...
3 KB (146 words) - 03:26, 8 July 2024
Methicillin (USAN), also known as meticillin (INN), is a narrow-spectrum β-lactam antibiotic of the penicillin class. Methicillin was discovered in 1960....
8 KB (698 words) - 00:47, 29 April 2024
L-lysine-lactamase (redirect from L-lysine-1,6-lactam lactamhydrolase)
L-lysine 1,6-lactam + H2O ⇌ {\displaystyle \rightleftharpoons } L-lysine Thus, the two substrates of this enzyme are L-lysine 1,6-lactam and H2O, whereas...
2 KB (170 words) - 14:41, 26 August 2023
to penicillins and cephalosporins, carbapenems are members of the beta-lactam antibiotics drug class, which kill bacteria by binding to penicillin-binding...
30 KB (3,489 words) - 16:49, 6 July 2024
used in those who are allergic to penicillin. It is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is similar in effect to cloxacillin...
23 KB (2,058 words) - 11:30, 1 July 2024
synthesize β-lactams. Achiral ketenes and imines, in the presence of a chiral nucleophilic catalyst, are allowed to react to make β-lactams in high yields...
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responsible for breaking down beta-lactams). Beta-lactam bacterial resistance can also be dealt with by administering beta-lactam antibiotics with drugs that...
27 KB (2,490 words) - 19:28, 15 July 2024
allergic reactions including anaphylaxis. Those who are allergic to other β-lactam have a low rate of allergy to aztreonam. Use in pregnancy appears to be...
16 KB (1,428 words) - 22:24, 12 July 2024
enzymology, a 2-aminohexano-6-lactam racemase (EC 5.1.1.15) is an enzyme that catalyzes the chemical reaction L-2-aminohexano-6-lactam ⇌ {\displaystyle \rightleftharpoons...
2 KB (167 words) - 12:25, 26 August 2023
Caprolactam (redirect from Aminocaproic lactam)
organic compound with the formula (CH2)5C(O)NH. This colourless solid is a lactam (a cyclic amide) of caproic acid. Global demand for this compound is approximately...
8 KB (771 words) - 09:26, 4 July 2024
generation cephalosporin that, like penicillins antibiotics, contains a β-lactam ring structure. Cephalosporins work as bactericidal antibiotics; that by...
8 KB (549 words) - 11:22, 4 June 2024
that cleaves the β-lactam ring of the penicillin molecule, rendering the antibiotic ineffective. Penicillinase-resistant β-lactam antibiotics, such as...
114 KB (12,720 words) - 17:06, 23 August 2024
the way by which the protein was discovered. All β-lactam antibiotics (except for tabtoxinine-β-lactam, which inhibits glutamine synthetase) bind to PBPs...
12 KB (1,289 words) - 18:30, 25 January 2024
color to amber or reddish suggests hydrolysis of the amide bond of the β-lactam ring, thereby affecting the antimicrobial activity of the antibiotic. Diluents...
34 KB (3,176 words) - 19:47, 17 August 2024