Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses. Lentiviruses are a...

used in clinical and research settings, pioneering lentivirals vector in gene therapy. Jesse Gelsinger's death in 1999 impeded gene therapy research in the...

and integrative vectors like lentiviral vectors are commonly employed for gene therapy. Chimeric viral vectors—such as hybrid vectors with qualities of...

Gene therapy using lentiviral vectors was being explored in early stage trials as of 2009.[needs update] In a Phase I clinical trial of three patients...

express a specific CAR, using a vector derived from an engineered lentivirus such as HIV (see Lentiviral vector in gene therapy). The CAR programs the T cells...

(2014). "Long-term safety and tolerability of Pro Savin, a lentiviral vector-based gene therapy for Parkinson's disease: A dose escalation, open-label, phase...

organism. Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and...

Gene therapy is being studied for some forms of epilepsy. It relies on viral or non-viral vectors to deliver DNA or RNA to target brain areas where seizures...

platelet-factor VIII, the gene that is mutated in human hemophilia. Lentiviral infection has advantages over other gene-therapy methods including high-efficiency...

"Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs". Molecular Therapy. 8 (2): 196–206. doi:10.1016/s1525-0016(03)00165-5...

in gene therapy is to substitute exogenous DNA in place of defective genes. Gene therapy has made a huge impact and opened many new possibilities in medical...

Emmanuel (February 2016). "Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β – Gene". Human Gene Therapy. 27 (2): 148–165. doi:10...

Naldini L (November 2007). "Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery". Nature Biotechnology...

development of lentiviral vectors for gene therapy. Trono obtained an M.D. from the University of Geneva in 1982 and completed a clinical training in internal...

retroviral and lentiviral vectors for gene therapy, allows it to be used for downstream purification of viral vectors. Heparin is being trialed in a nasal spray...

ancestor at > 450 million years ago. Gammaretroviral and lentiviral vectors for gene therapy have been developed that mediate stable genetic modification...

2009). "State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations". Current Gene Therapy. 9 (6): 459–74. doi:10...

acknowledged specialist in HIV, lentiviral gene transfer vectors, and their medical applications. His discovery of the central DNA-flap structure in the HIV genome...

therapy for sickle cell disease in humans were started in 2014. The clinical trials assessed the safety of lentiviral vector-modified bone marrow for adults...

mutagenesis Poletti, Valentina; Mavilio, Fulvio (2021). "Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases". Viruses. 13 (8): 5. doi:10.3390/v13081526...

and gene therapy. She has designed clinical trials based on lentiviral vector in gene therapy and pioneered the use of haematopoietic stem cell gene therapy...

Morton J.; Sorrentino, Brian P. (18 April 2019). "Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1". New England Journal of...

methods because they can transfer genes into a wide variety of human cells and have high transfer rates. Lentiviral vectors are also helpful due to their...

virus or viral vector. An example is the viral transfer of DNA from one bacterium to another and hence an example of horizontal gene transfer. Transduction...

Interfering RNA Delivery". Nonviral Vectors for Gene Therapy - Lipid- and Polymer-based Gene Transfer. Advances in Genetics. Vol. 88. pp. 71–110. doi:10...

"Improved lentiviral vectors for Wiskott–Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis". Gene Therapy. 15 (12):...

HIV-1, FIV has been engineered into a viral vector for gene therapy. Like other lentiviral vectors, FIV vectors integrate into the chromosome of the host...

are transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A gene to insert a functional gene to produce the ARSA enzyme. When...

Morris KV, Rossi JJ (March 2006). "Lentiviral-mediated delivery of siRNAs for antiviral therapy". Gene Therapy. 13 (6): 553–8. doi:10.1038/sj.gt.3302688...

functional copy of the ABCD1 gene using a lentiviral vector. Patients undergo myeloablative chemotherapy conditioning to kill stem cells in the bone marrow before...