The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the...

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member...

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor...

acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor that is...

The liver receptor homolog-1 (LRH-1) also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that...

Webb P, Gustafsson JA (March 2014). "Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA". Nature Structural & Molecular...

Y (18 February 2016). "Liver X receptor α is essential for the capillarization of liver sinusoidal endothelial cells in liver injury". Scientific Reports...

six weeks reduced markers of liver inflammation and fibrosis and increased insulin sensitivity. The Farnesoid X Receptor Ligand Obeticholic Acid in Nonalcoholic...

NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha...

dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a type of chronic liver disease. This condition...

acid receptor, both of which are activated by bile acids. Adopted orphan receptors in the nuclear receptor group include FXR, liver X receptor (LXR)...

"Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine". Journal of Lipid Research. 48 (12): 2664–72. doi:10...

sterol-activated liver X receptor. Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes...

biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I...

transport of fatty acids from adipose tissue to the liver is increased. Impairment or inhibition of receptor molecules (PPAR-α, PPAR-γ and SREBP1) that control...

In liver FGF21 expression is regulated by PPARα and levels rise substantially with both fasting and consumption of ketogenic diets. Liver X receptor (LXR)...

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded...

potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). The transcription of many genes is activated by FXR,...

(SREBP-1c) in response to feeding/insulin in living animals. Although liver X receptors (LXRs) modulate the expression of sterol regulatory element binding...

"Interleukin-1 family cytokines in liver diseases." Mediators of inflammation 2015 (2015). Fowler, Ashley J., et al. "Liver X receptor activators display anti-inflammatory...

estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR)...

"Liver X receptors (LXR) as therapeutic targets in dyslipidemia". Cardiovascular Therapeutics. 26 (4): 297–316. doi:10.1111/j.1755-5922.2008.00062.x....

inhibitors, have been shown to effectively kill cancer cells. Activated liver X receptor (LXR) forms a complex with corepressors to suppress the inflammatory...

Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is a condition of the liver in which the normal functioning...

(December 2016). "Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease". Endocrinology and Metabolism...

Cafestol may act as an agonist ligand for the nuclear receptor farnesoid X receptor and pregnane X receptor, blocking cholesterol homeostasis. Thus cafestol...

(2008). "p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver". Gastroenterology. 135 (1):...

phosphorylation-dephosphorylation. CYP7A1 is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol (to be specific, oxysterol) levels are high...

cannabinoid receptors, termed CB1 and CB2. The CB1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and...

treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH). In combination with cenicriviroc, a CCR2 and CCR5 receptor inhibitor, it is undergoing...