Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. The process...

activation. Parkin plays a crucial role in mitophagy and clearance of reactive oxygen species. Mitophagy is the elimination of damaged mitochondria in...

autophagy. In the selective autophagy is the autophagy of organelles; mitophagy, lipophagy, pexophagy, chlorophagy, ribophagy and others. Macroautophagy...

collaborations. Gottlieb leads ongoing research focused on autophagy, mitophagy and biogenesis, with particular attention to the molecular basis of myocardial...

required to clear damaged mitochondria from the cell (a process called mitophagy). BRCA1 (also known as FANCS) interacts with the ribosomal DNA (rDNA)...

Mitochondrial metabolic rates Mitochondrial permeability transition pore Mitophagy Nebenkern Oncocyte Oncocytoma Paternal mtDNA transmission Plastid Submitochondrial...

uncoupling agent in cell and molecular biology, particularly in the study of mitophagy, where it was integral in discovering the role of the Parkinson's disease-associated...

contribution to inflammaging is a decline in effective autophagy and mitophagy capacity. This is an essential process for cellular housekeeping that...

014. PMID 30459101. Kirienko NV, Ausubel FM, Ruvkun G (February 2015). "Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa"...

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial...

anticancer therapy. It is known to suppress tumors and plays a role in mitophagy and apoptosis. AMBRA1 can be found in the cytoskeleton and mitochondria...

with low LAMP2 protein level and lysosome number (both important for mitophagy: the degradation of defective mitochondria pathway), could be implicated...

differentiation and maturation of erythrocytes and lymphocytes by the process of mitophagy with the help of its regulator BNIP3. Using a gene knockout technique...

mitochondria that has been rendered nonfunctional in a process known as mitophagy. However, mutations in the Parkin and pink1 genes have been associated...

properly. UPRmt causes the sirtuin SIRT3 to activate antioxidant enzymes and mitophagy. Mitochondrial electron transport chain mutations that extend the life...

selectively degrade damaged cytosolic organelles such as mitochondria (mitophagy). However, when the cell is starved or stressed, autophagosomes can also...

deal with malfunctioning mitochondria in neurons, a process known as mitophagy. Patients with Parkinson's disease typically show mutations on two proteins...

destruction. He also investigated molecular mechanisms of autophagy and mitophagy. He received the NIH Director’s Award in 1992, 2011, and 2015. For 2021...

increase of the autophagy of mitochondria, a process called mitophagy. An increase in mitophagy triggers the development and progression of cancer. MUC-1...

of both mitochondrial synthesis (biogenesis), as well as degradation (mitophagy) in muscle. In his research, he also employs multi-disciplinary approaches...

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial...

WFS2. In some cases, mutation of the gene can lead to premature aging, mitophagy and mitochondrial dysfunction. In studies using mice, WFS2 caused a decrease...

cell response against viral infection in lupus patients by suppressing mitophagy". Science Advances. 8 (24): eabo4271. Bibcode:2022SciA....8O4271C. doi:10...

nutrient availability on to stress responsive elements and autophagy/mitophagy mechanisms. It is encoded by a 1.46 kbp gene located on chromosome 15...

in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy. Molecular Cell 55:451-66. Henry CM and Martin SJ (2017) Caspase-8 Acts...

His recent work has identified a role for Gp78 in regulation of basal mitophagy, production of reactive oxygen species and a distinct class of ribosome-studded...

CNN. 2011-09-19. Kobayashi S, Liang Q (February 2015). "Autophagy and mitophagy in diabetic cardiomyopathy". Biochimica et Biophysica Acta (BBA) - Molecular...

123.3191.309. PMID 13298683. Mahla, RS; et al. (2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial...

process necroptosis cellular response to UV-C negative regulation of mitophagy regulation of mitochondrial membrane permeability involved in apoptotic...

DA (2015). "Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle". American Journal of Physiology. 308 (9): C710-719...