A morphogen is a substance whose non-uniform distribution governs the pattern of tissue development in the process of morphogenesis or pattern formation...

flag model is a conceptual definition of a morphogen, described by Lewis Wolpert in the 1960s. A morphogen is defined as a signaling molecule that acts...

embryogenesis. Bicoid was the first protein demonstrated to act as a morphogen. Although bicoid is important for the development of Drosophila and other...

the neural tube), and later from the floor plate cells. Shh acts as a morphogen, meaning that it acts in a concentration-dependent manner to specify cell...

for the first time the presence and behavior of filopodia with a known morphogen signaling protein - decapentaplegic. Decapentaplegic is expressed in the...

(Dpp) is a key morphogen involved in the development of the fruit fly Drosophila melanogaster and is the first validated secreted morphogen. It is known...

limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized...

Democratic Party for the People, a Japanese political party Decapentaplegic, a morphogen involved in development Diketopyrrolopyrrole dye, a class of organic dyes...

morphogenesis. Morphogens are soluble molecules that can diffuse and carry signals that control cell differentiation via concentration gradients. Morphogens typically...

signaling molecules called morphogens that pattern uniform pools of cells in a concentration- and time-dependent manner. The morphogen sonic hedgehog (Shh)...

mesenchymal compartment. Continued signaling by BMP, FGF, and RA, the morphogens that initially induced placode formation, collectively coordinate the...

environment and intercellular signaling. Thus, as individuals develop, morphogens activate or silence genes in an epigenetically heritable fashion, giving...

developing organisms without the classical requirement of diffusible morphogens. Studies in chick and mouse embryonic development suggest that the patterns...

chemical signal, a morphogen, resulting in the growth of a certain type of structure, say a darkly pigmented patch of skin. If the morphogen is present everywhere...

in early embryo development, exhibit a ratchet effect in response to morphogen concentrations. The low receptor occupancy permits increases in receptor...

are a class of plant hormones (or plant-growth regulators) with some morphogen-like characteristics. Auxins play a cardinal role in coordination of many...

Antennapedia regulates the formation of anterior limbs in the embryo. Morphogens: These are molecules that form gradients in embryonic development and...

long-range transport of hydrophobic intercellular messengers, like the morphogen Indian hedgehog (protein). Nascent VLDL released from the liver contains...

which the focus creates the morphogen, or by the sink model, in which the focus generates a gradient by removing a morphogen which was created elsewhere...

the alar plate to develop sensory neurons. Opposing gradients of such morphogens as BMP and SHH form different domains of dividing cells along the dorsal...

Netrin-1, a morphogen that will interact with the Deleted in Colorectal Cancer (DCC) receptor on growth cones of the RGC axon. This morphogen initially...

(SHFM) locus, the large number of morphogens involved in limb development, the complex interactions between these morphogens, the involvement of modifier genes...

candidates of epigenetic regulators of cellular differentiation. These morphogens are crucial for development, and include bone morphogenetic proteins,...

200–204. doi:10.1016/0968-0004(87)90094-6. Rogers KW, Schier AF (2011). "Morphogen gradients: from generation to interpretation". Annual Review of Cell and...

morphogen slope dependency on growth, highlighting importantly that her model could account for normal growth despite local variations in morphogen concentration...

fate, and may even generate other morphogens that signal back to the original cell. Over longer distances morphogens may use the active process of signal...

Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...

it offered the best regeneration results. Lately, the introduction of morphogen-enhanced bone graft substitutes have shown similar success rates and quality...

involves the action of morphogen gradients within the syncytium. As there are no cell boundaries in the syncytium, these morphogens can influence nuclei...

eliminated by glucuronidation in the liver. All-trans-retinoic acid is a morphogen signaling molecule, which means it is concentration dependent; malformations...