• Thumbnail for Phenylalanine ammonia-lyase
    enzyme phenylalanine ammonia lyase (EC 4.3.1.24) catalyzes the conversion of L-phenylalanine to ammonia and trans-cinnamic acid.: L-phenylalanine = trans-cinnamate...
    20 KB (2,185 words) - 06:53, 3 November 2024
  • Phenylalanine/tyrosine ammonia-lyase (EC 4.3.1.25, PTAL, bifunctional PAL) is an enzyme with systematic name L-phenylalanine(or L-tyrosine):trans-cinnamate(or...
    3 KB (285 words) - 12:08, 29 November 2023
  • Thumbnail for Histidine ammonia-lyase
    histidase are associated with histidinemia and urocanic aciduria. Phenylalanine ammonia-lyase, another enzyme that contains the MIO cofactor GRCh38: Ensembl...
    5 KB (638 words) - 11:14, 18 May 2024
  • Thumbnail for Phenylalanine
    Phenylalanine is converted to cinnamic acid by the enzyme phenylalanine ammonia-lyase. Phenylalanine is biosynthesized via the shikimate pathway. The genetic...
    28 KB (2,386 words) - 21:26, 25 July 2024
  • Thumbnail for Hesperidin
    pathway, in which the natural amino acid L-phenylalanine undergoes a deamination by phenylalanine ammonia lyase to afford (E)-cinnamate. The resulting monocarboxylate...
    15 KB (1,228 words) - 16:46, 20 September 2024
  • DOPA-reductive deaminase, DOPARDA; systematic name 3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming)) catalyses the following...
    1 KB (116 words) - 04:16, 28 November 2023
  • Thumbnail for Cinnamaldehyde
    biosynthesized from phenylalanine. Deamination of L-phenylalanine into cinnamic acid is catalyzed by phenylalanine ammonia lyase (PAL). PAL catalyzes...
    20 KB (1,852 words) - 14:49, 9 September 2024
  • Thumbnail for Phenylketonuria
    clinical trials to investigate PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase or 'PAL'), which is an enzyme substitution therapy in which the...
    57 KB (6,179 words) - 14:29, 25 October 2024
  • Thumbnail for Phenylpropanoid
    and scent compounds. Phenylalanine is first converted to cinnamic acid by the action of the enzyme phenylalanine ammonia-lyase (PAL). Some plants, mainly...
    6 KB (619 words) - 17:20, 7 October 2024
  • phenylketonuria. It is a phenylalanine (Phe)‑metabolizing enzyme. Chemically, it is a pegylated derivative of the enzyme phenylalanine ammonia-lyase that metabolizes...
    8 KB (531 words) - 03:53, 22 May 2024
  • Thumbnail for Dehydroalanine
    important electrophilic catalytic residue in histidine ammonia-lyase and phenylalanine ammonia-lyase enzymes, but the active residue was later found instead...
    8 KB (706 words) - 04:26, 3 February 2024
  • Thumbnail for Capsaicin
    studies identified phenylalanine and valine as the precursors to capsaicin. Enzymes of the phenylpropanoid pathway, phenylalanine ammonia lyase (PAL), cinnamate...
    59 KB (5,930 words) - 11:59, 20 November 2024
  • Thumbnail for Threonine ammonia-lyase
    Threonine ammonia-lyase (EC 4.3.1.19, systematic name L-threonine ammonia-lyase (2-oxobutanoate-forming), also commonly referred to as threonine deaminase...
    15 KB (1,683 words) - 16:02, 26 August 2023
  • Thumbnail for Cinnamic acid
    Its biosynthesis involves the action of the enzyme phenylalanine ammonia-lyase (PAL) on phenylalanine. It is obtained from oil of cinnamon, or from balsams...
    9 KB (686 words) - 16:52, 23 October 2024
  • Thumbnail for Vanillin
    the phenylpropanoid pathway starting with L-phenylalanine, which is deaminated by phenylalanine ammonia lyase (PAL) to form t-cinnamic acid. The para position...
    37 KB (3,760 words) - 19:49, 24 November 2024
  • Thumbnail for Tyrosine ammonia-lyase
    Ammonia + H+ L-tyrosine = trans-p-hydroxycinnamate + NH3 EC 4.3.1.24 (phenylalanine ammonia-lyase) EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase)...
    2 KB (212 words) - 21:37, 18 August 2023
  • Permissive action link, a security device for nuclear weapons Phenylalanine ammonia-lyase, a class of enzymes PAL Airlines, Canada PAL Airlines (Chile)...
    4 KB (467 words) - 13:25, 8 August 2024
  • Thumbnail for Flavan-3-ol
    indicated in blue, abbreviated as follows: E1, phenylalanine ammonia lyase (PAL), E2, tyrosine ammonia lyase (TAL), E3, cinnamate 4-hydroxylase, E4, 4-coumaroyl:...
    19 KB (1,905 words) - 20:10, 13 May 2024
  • Thumbnail for Quercetin
    phenylalanine is converted to 4-coumaroyl-CoA in a series of steps known as the general phenylpropanoid pathway using phenylalanine ammonia-lyase,...
    26 KB (2,467 words) - 13:46, 2 November 2024
  • (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase) EC 4.3.1.6: β-alanyl-CoA ammonia-lyase...
    62 KB (7,931 words) - 19:04, 4 January 2024
  • Thumbnail for PEGylation
    DMG-PEG 2000. Pegvaliase (Biomarin) – PEGylated recombinant phenylalanine ammonia-lyase for the treatment of Phenylketonuria, approved by the FDA for...
    27 KB (2,986 words) - 00:38, 24 October 2024
  • first enzyme involved is phenylalanine ammonia-lyase (PAL) that converts L-phenylalanine to trans-cinnamic acid and ammonia. Gallic acid is formed from...
    12 KB (1,163 words) - 14:21, 2 October 2024
  • Thumbnail for Silibinin
    coat. Starting with the transformation of phenylalanine into cinnamic acid mediated by phenylalanine ammonia-lyase. Cinnamic acid will then go through two...
    21 KB (2,233 words) - 08:08, 21 August 2024
  • Thumbnail for Ephedrine
    new pathway proposed suggests that phenylalanine first forms cinnamoyl-CoA via the enzymes phenylalanine ammonia-lyase and acyl CoA ligase. The cinnamoyl-CoA...
    66 KB (6,171 words) - 19:40, 17 November 2024
  • Thumbnail for Cathinone
    khat begins with L-phenylalanine and the first step is carried out by L-phenylalanine ammonia lyase (PAL), which cleaves off an ammonia group and creates...
    27 KB (2,633 words) - 14:32, 6 November 2024
  • Thumbnail for Apigenin
    L-phenylalanine, first the amino acid is non-oxidatively deaminated by phenylalanine ammonia lyase (PAL) to make cinnamate, followed by oxidation at the para position...
    12 KB (1,048 words) - 22:47, 25 October 2024
  • Thumbnail for Rutin
    alba L.) leaves begins with phenylalanine, which produces cinnamic acid under the action of phenylalanine ammonia lyase (PAL). Cinnamic acid is catalyzed...
    13 KB (1,077 words) - 23:11, 12 September 2024
  • Thumbnail for Xanthohumol
    cones. L-Phenylalanine serves as the starting material, which is converted to cinnamic acid by the PLP-dependent phenylalanine ammonia lyase. Cinnamic...
    9 KB (833 words) - 10:44, 16 June 2024
  • 2017, Codexis developed a recombinant phenylalanine ammonia-lyase (PAL) enzyme, to act as a substitute phenylalanine hydroxylase (PAH) enzyme for people...
    7 KB (472 words) - 08:14, 19 October 2024
  • 20) Category:EC 4.3.1 Phenylalanine ammonia-lyase (EC 4.3.1.24) Category:EC 4.4.1 Cystathionine gamma-lyase Cystathionine beta-lyase Leukotriene C4 synthase...
    33 KB (3,650 words) - 18:48, 10 September 2024