known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene. The protein encoded by this gene is a...
24 KB (2,714 words) - 12:40, 22 December 2023
that subunits of the mammalian complex, including ARID1A, PBRM1, SMARCB1, SMARCA4, and ARID2, are frequently mutated in human cancers. It has been noted...
38 KB (3,947 words) - 18:18, 28 June 2024
associated to this syndrome, including SOX11, ARID2, DPF2, PHF6, SMARCA2, SMARCA4, SMARCB1, SMARCC2, SMARCE1, SOX4. The diagnosis is generally based on the...
8 KB (717 words) - 04:44, 6 August 2024
kinase LKB1, and its role in regulating the chromatin remodeling protein SMARCA4 and modeling metabolic processes in breast and lung cancers. Marignani...
12 KB (1,528 words) - 23:40, 20 November 2024
found mutated in a wide range of neoplasms. The SWI/SNF ATPase BRG1 (or SMARCA4) is the most frequently mutated chromatin remodeling ATPase in cancer....
50 KB (5,523 words) - 09:43, 3 December 2023
HELLS, HELQ, HELZ, HFM1, HLTF, IFIH1, NAV2, PIF1, RECQL, RTEL1, SHPRH, SMARCA4, SMARCAL1, WRN, WRNIP1 RNA helicase database Wu Y (2012). "Unwinding and...
56 KB (6,916 words) - 17:01, 27 August 2024
MYCBP2 MYCBP NMI NFYB NFYC P73 PCAF PFDN5 RuvB-like 1 SAP130 SMAD2 SMAD3 SMARCA4 SMARCB1 SUPT3H TIAM1 TADA2L TAF9 TFAP2A TRRAP WDR5 YY1 and ZBTB17. C2orf16...
57 KB (6,672 words) - 01:42, 9 October 2024
Recent research has found an inactivating germline and somatic mutation of SMARCA4 gene. The hypercalcemic subtype is very aggressive and has an overall survival...
198 KB (21,235 words) - 06:47, 19 November 2024
NRIP1, NCOR1, NCOA1, NCOA2, NCOA3, POU2F1, RANBP9, RELA, SMAD3, SMARCD1, SMARCA4 STAT3, STAT5B, Thioredoxin, TRIM28, and YWHAH. Membrane glucocorticoid...
37 KB (4,035 words) - 09:01, 19 August 2024
Turcot syndrome. Recurrent mutations in the genes CTNNB1, PTCH1, MLL2, SMARCA4, DDX3X, CTDNEP1, KDM6A, and TBR1 were identified in individuals with medulloblastoma...
36 KB (3,455 words) - 22:51, 26 April 2024
RAD51, RCHY1, RELA, Reprimo[citation needed] RPA1, RPL11, S100B, SUMO1, SMARCA4, SMARCB1, SMN1, STAT3, TBP, TFAP2A, TFDP1, TIGAR, TOP1, TOP2A, TP53BP1...
124 KB (13,220 words) - 11:01, 30 August 2024
Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR (February 2017). "Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin". Nature...
13 KB (1,435 words) - 09:07, 17 May 2024
PALB2 POLR2A PPP1CA Rad50 RAD51 RBBP4 RBBP7 RBBP8 RELA RB1 RBL1 RBL2 RPL31 SMARCA4 SMARCB1 STAT1 TOPBP1 UBE2D1 USF2 VCP XIST ZNF350 GRCh38: Ensembl release...
121 KB (13,568 words) - 14:53, 22 October 2024
SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57...
13 KB (1,300 words) - 05:47, 17 September 2023
(PTPkappa), PTPRT (PTPrho), PTPRU (PCP-2), PSEN1, PTK7 RuvB-like 1, SMAD7, SMARCA4 SLC9A3R1, USP9X, and VE-cadherin. XIRP1 Catenin GRCh38: Ensembl release...
107 KB (12,347 words) - 05:01, 2 November 2024
article for SMARCS3) Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription...
35 KB (3,523 words) - 05:39, 8 April 2024
GTF2H4, MED21, MED26, PCAF, POLR2C, POLR2E, POLR2H, POLR2L, PQBP1, SMARCA2, SMARCA4 SMARCB1, SMYD3, SND1, SUPT5H, TAF11, TBP, TCEA1, TCERG1, and ZNF74. ENSG00000181222...
12 KB (1,339 words) - 19:29, 9 April 2024
NRIP1 PDLIM1 POU4F1 POU4F2 PRDM2 PRMT2 RBM39 RNF12 SAFB SAFB2 SHC1 SHP SMARCA4 SMARCE1 Src TR2 TR4 TDG TRIM24 and XBP1. GRCh38: Ensembl release 89: ENSG00000091831...
58 KB (6,133 words) - 06:55, 2 November 2024
RBMX Dispensable No RUNX3 Dispensable Yes SFPQ Essential Yes Yes Core SMARCA4 (BRG1) Essential No Patch SRSF10 Important No SS18L1 n.d. Yes Yes TAF14...
19 KB (1,862 words) - 06:26, 27 May 2024
testes. STK11 has been shown to interact with: CDC37, * FYN HSP90AA1 LYK5 SMARCA4 ESR1 Paola Marignani (living), scientist and university professor, research...
25 KB (2,831 words) - 17:15, 10 September 2024
(22q11) and transcription activator BRG1/ATP-dependent chromatin remodeler (SMARCA4) located on the short arm of chromosome 19 (19p13.2). Considerable debate...
9 KB (1,077 words) - 03:42, 1 June 2024
to interact with: BRCA1, CHUK, ERCC4, FANCE, FANCF, FANCG, FANCC, IKK2, SMARCA4 SNX5 SPTAN1 and HES1 GRCh38: Ensembl release 89: ENSG00000187741 – Ensembl...
38 KB (4,760 words) - 00:26, 4 January 2024
15282 SMARCA1 HGNC:11097 P28370 15283 SMARCA2 HGNC:11098 P51531 15284 SMARCA4 HGNC:11100 P51532 15285 SMARCA5 HGNC:11101 O60264 15286 SMARCAD1 HGNC:18398...
242 KB (17 words) - 18:43, 6 October 2024
"Update on genetically defined lung neoplasms: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumors". Virchows Archiv. 478 (1): 21–30. doi:10...
21 KB (2,602 words) - 00:37, 1 August 2024
Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Mol Cell. 2019 Sep 5;75(5):891-904.e7. doi: 10.1016/j.molcel.2019.06.024...
9 KB (987 words) - 14:07, 12 November 2024
WL, Veverka V, Zhao K, Crabtree GR (January 2018). "Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers"...
57 KB (6,636 words) - 16:43, 6 November 2024
types of liver damage. ARID1A has been shown to interact with SMARCB1 and SMARCA4. GRCh38: Ensembl release 89: ENSG00000117713 – Ensembl, May 2017 GRCm38:...
16 KB (1,805 words) - 20:02, 29 October 2024
SMARCE1 has been shown to interact with Estrogen receptor alpha, SMARCB1 and SMARCA4. GRCh38: Ensembl release 89: ENSG00000073584 – Ensembl, May 2017 GRCm38:...
9 KB (1,124 words) - 02:45, 16 July 2024
Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR (February 2017). "Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin". Nature...
8 KB (964 words) - 21:52, 25 April 2024
kinase 8, Myc, P53, POLR2A, PPP1CA, PPP1CB, PPP1CC, PPP1R15A, SMARCA2, SMARCA4, SMARCC1, SMARCE1, SS18, and XPO1. ENSG00000275837 GRCh38: Ensembl release...
14 KB (1,630 words) - 02:17, 1 June 2024