mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome...

all other mammals, and most chordates. SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. The first is a dimer (consists...

to hydrogen peroxide by two dismutases including superoxide dismutase 2 (SOD2) in mitochondrial matrix and superoxide dismutase 1 (SOD1) in mitochondrial...

cell aging. Mitochondrial superoxide dismutase (SOD2) ordinarily protects against ROS. Loss of SOD2 in mouse epidermal cells was observed to cause cellular...

superoxide dismutase are present. SOD1 is located primarily in the cytoplasm, SOD2 in the mitochondria and SOD3 is extracellular. The first is a dimer (consists...

pathways operate at higher activation energy than the concerted pathway. SOD2 uses cyclic proton-coupled electron transfer reactions to convert superoxide...

in genes involved in the response to oxidative stress such as CAT, SOD1, SOD2, SOD3, NFE2L2, HMOX1, GST-M1 or GST-T1 supporting the association of elevated...

Samper E, Melov S, Xu Z (Jan 2006). "Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice". PLOS...

mediated by mitochondrial antioxidants such as manganese superoxide dismutase (SOD2) and glutathione peroxidase. Over production of ROS (oxidative stress) is...

dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression". Free Radical...

short for sodomite. Date: 1818. Soanes, Catherine; Hawker, Sara (2005). "sod2". Compact Oxford English Dictionary. Oxford University Press. ISBN 978-0-19-861022-9...

is increased and antioxidant defenses including SOD1, SOD2, and PRDX3 are decreased. SOD1, SOD2, and PRDX3 are known to be pro-oncogenic and be involved...

FOXO3a transcriptionally increased gene expression of the antioxidant enzymes SOD2 and catalase. Plasma levels of β-hydroxybutyrate increase with fasting or...

Banerjee M (Jan 2015). "Association of Superoxide dismutases (SOD1 and SOD2) and Glutathione peroxidase 1 (GPx1) gene polymorphisms with type 2 diabetes...

Mitochondria Deacetylase Metabolism 126-382 (of 399aa) H3K56ac, H4K14ac SOD2, PDH, IDH2, GOT2, FoxO3a Neurodegenerative diseases, Cancer: B cell chronic...

unlike G93A mice, deficiency of the major mitochondrial antioxidant enzyme, SOD2, has no effect on their disease course. G93A (glycine 93 changed to alanine)...

Hitchler MJ, Oberley LW, Domann FE (December 2008). "Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells". Free Radical Biology...

associated with a number of epigenetic markers, including methylation of the Sod2 and MMP-9 genes, an increase in transcription of LSD1, a H3K4 and H3K9 demethylase...

(SOD/catalase) mimetics has been reported to extend life-span. Mice with deficient SOD2 die prematurely, exhibiting severe metabolic and mitochondrial defects. Treatment...

early 2000s. Mice with reduced expression of the mitochondrial antioxidant, SOD2, accumulated oxidative damage and developed cancer, but did not age faster...

iron-containing SODs from Escherichia coli and the mitochondrial MnSOD (SOD2), now known to be an essential protein in mammals. He spent the rest of his...

O14544 15488 SOCS7 HGNC:29846 O14512 15489 SOD1 HGNC:11179 P00441 15490 SOD2 HGNC:11180 P04179 15491 SOD3 HGNC:11181 P08294 15492 SOHLH1 HGNC:27845 Q5JUK2...

containing copper and zinc, found often in intracellular cytoplasmic spaces. FeMn(SOD2) is a tetramer produced by a leader peptide targeting the manganese containing...

co-complex interactions. POLG appears to interact with POLG2, Dlg4, Tp53, and Sod2. GRCh38: Ensembl release 89: ENSG00000140521 – Ensembl, May 2017 GRCm38:...

activation of yet unknown downstream targets, with a putative target being SOD2. FOXO1 belongs to the forkhead family of transcription factors that are characterized...

dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression". Free Radical...

revealed a potential interaction had been found with Superoxide dismutase 2 (SOD2), which had been identified in a yeast Two-hybrid screening study. TMEM131...

Journal of Pharmacology and Experimental Therapeutics, 2004 PMID 15231866 SOD2-deficiency anemia: protein oxidation and altered protein expression reveal...