prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes the major 3'->5' DNA exonuclease in human cells...

of different genes, of which nine have been identified to date, namely: TREX1, RNASEH2A, RNASEH2B, RNASEH2C (which together encode the ribonuclease H2...

C-terminal region of the TREX1 gene. This disease is associated witih DNA damage (chromosome damage) caused by a toxic mutant TREX1 protein, which causes...

for XML), a subset of Regular Language description for XML The proteins TREX1 and TREX2 T. rex (disambiguation) This disambiguation page lists articles...

vasoconstriction or microvascular injury brought on by cold. A missense mutation in TREX1, encoding the 3′–5′ repair exonuclease 1, was found in affected individuals...

Aicardi–Goutières syndrome, a hereditary disease caused by mutations in the TREX1, RNASEH2B, RNASEH2C, RNASEH2A, ADAR1, SAMHD1, IFIH1, LSM11, or RNU7-1 gene...

1:30,000-50,000 ADULT syndrome TP63 dominant Aicardi–Goutières syndrome TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, IFIH1 1:19,500,000 Albinism...

2024 were classified as inborn errors of immunity genes, i.e., DNASE1L3, TREX1, IFIH1, Tartrate-resistant acid phosphatase and PRKCD and 28 other genes...

active L1 genomic retroelements by the three prime repair exonuclease 1 (TREX1) and excision repair cross complementing 1(ERCC) appear to mimic the action...

Aicardi–Goutières syndrome (AGS). Mutations in the 3’ repair exonuclease, TREX1, cause endogenous retroelements to accumulate in the cytosol, which can...

disease or during convalescence. Certain genetic polymorphisms (in the TREX1 gene) have been linked to susceptibility towards developing COVID-toe. A...

type I interferon. AGS can also be caused by mutations in other genes: TREX1, SAMHD1, ADAR, and MDA5/IFIH1, all of which are involved in nucleic acid...

deposition). Familial Mediterranean fever Aicardi–Goutières syndrome with TREX1, SAMHD1 or IFIH1 mutations Spondyloenchondro-dysplasia with immune dysregulation...

active L1 genomic retroelements by the three prime repair exonuclease 1 (TREX1) and excision repair cross complementing 1 (ERCC) appear to mimic the action...

Mazur DJ, Perrino FW (Aug 1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases". J Biol...

092448. PMID 15568983. Yang, Y. G.; Lindahl, T; Barnes, D. E. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and...

domain that carries out the 3’→5’ exonuclease and proofreading function. TREX1, the major 3'→5' exonuclease in humans, was initially called DNase III because...

2015;75:2232-2242. Vanpouille-Box C, Alard A, Aryankalayil MJ, et al. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat Commun. 2017 Jun...

are classified as inborn errors of immunity genes, i.e., the DNASE1L3, TREX1, IFIH1, Tartrate-resistant acid phosphatase, and PRKCD genes and 29 other...

Q5T2D2 17336 TREML4 HGNC:30807 Q6UXN2 17337 TRERF1 HGNC:18273 Q96PN7 17338 TREX1 HGNC:12269 Q9NSU2 17339 TREX2 HGNC:12270 Q9BQ50 17340 TRG HGNC:12271 [3]...

Juvenile Batten disease and Sanfilippo syndrome type B. TFEB is activated in Trex1-deficient cells via inhibition of mTORC1 activity, resulting in an expanded...

Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products". Journal of Virology...

218000; SLC12A6 Aicardi–Goutières syndrome 1, dominant and recessive; 225750; TREX1 Aicardi–Goutières syndrome 2; 610181; RNASEH2B Aicardi–Goutières syndrome...