U.S. Route 3 (US 3) is a United States Numbered Highway running 277.90 miles (447.24 km) from Cambridge, Massachusetts, through New Hampshire, to the Canada–United...

U.S. Route 302 (US 302) is an east–west spur of U.S. Route 2 in northern New England in the United States. It currently runs 171 miles (275 km) from Montpelier...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) was one of the original highways in the United States Numbered Highway System. It was established...

U.S. Route 65 (US 65) is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U...

U.S. Route 310 (US 310) is a spur of historic U.S. Route 10, now Interstate 90. It runs for 108 miles (174 km) from Laurel, Montana, to Greybull, Wyoming...

U.S. Route 283 is a spur of U.S. Route 83. It currently runs for 731 miles (1,175 km) from Brady, Texas at U.S. Route 87 to Lexington, Nebraska at U.S...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

U.S. Route 385 (US 385) is a spur of U.S. Route 85 that runs for 1,206 miles (1,941 km) from Deadwood, South Dakota to Big Bend National Park in Texas...

U.S. Route 31E (US 31E) is the eastern parallel route for U.S. Highway 31 from Nashville, Tennessee, to Louisville, Kentucky. US 31E begins as the Ellington...

U.S. Route 277 (US 277, US-277) is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 165 is a north–south United States highway spur of U.S. Highway 65. It currently runs for 412 miles (663 km) from U.S. Route 90 in Iowa, Louisiana...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 401 (US 401) is a north–south United States highway, a spur of U.S. Route 1, that travels along the Fall Line from Sumter, South Carolina to...

U.S. Route 641 (US 641) is a U.S. Route in Tennessee and Kentucky. It runs for 165.45 miles (266.27 km) from US 64 south of Clifton, Tennessee to an intersection...

U.S. Route 136 is an east-west U.S. highway that is a spur route of U.S. Route 36. It runs from Edison, Nebraska, at U.S. Route 6 and U.S. Route 34 to...

U.S. Route 99 (US 99) was a main north–south United States Numbered Highway on the West Coast of the United States until 1964, running from Calexico,...

The United States Numbered Highway System (often called U.S. Routes or U.S. Highways) is an integrated network of roads and highways numbered within a...

connects U.S. Route 62 U.S. Route 75 (US 62/US 75) in Henryetta with U.S. Route 64 (US 64) in Warner. The highway no longer meets the former route of its...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 167 is a north-south United States Highway within the U.S. states of Louisiana and Arkansas. It runs for 500 miles (800 km) from Ash Flat, Arkansas...

U.S. Route 380 (US 380) is an east–west United States highway. The highway's eastern terminus is in Greenville, Texas at an intersection with Interstate...

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International...

U.S. Route 202 (US 202) is a spur route of US 2. It follows a northeasterly and southwesterly direction stretching from Delaware in the south to Maine...

U.S. Route 70 or U.S. Highway 70 (US 70) is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

U.S. Route 72 (US 72) is an east–west United States highway that travels for 317.811 miles (511.467 km) from southwestern Tennessee, throughout North...

U.S. Route 360 (US 360) is a spur route of US 60. The U.S. Highway runs 225.3 miles (362.6 km), entirely within the state of Virginia, from US 58 Business...