U.S. Route 378 (US 378) is a spur of US 78 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 234.30 miles (377.07 km) from US 78...

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

connect US 178, South Carolina Highway 39 (SC 39), and SC 121 with US 378 and SC 194. It is known as Travis Avenue and is an unsigned highway. U.S. Route 178...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 401 (US 401) is a north–south United States highway, a spur of U.S. Route 1, that travels along the Fall Line from Sumter, South Carolina to...

U.S. Route 76 (US 76) is an east–west U.S. highway in the Southeastern United States that travels for 548 miles (882 km). Its western terminus is at US...

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

U.S. Route 521 (US 521) is a north–south United States Highway that traverses 177.3 miles (285.3 km), from Georgetown, South Carolina, to Charlotte, North...

U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S...

U.S. Route 277 (US 277, US-277) is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route...

U.S. Route 701 (US 701) is an auxiliary route of US 1 in the U.S. states of South Carolina and North Carolina. The U.S. Highway runs 171.45 miles (275...

U.S. Route 15 or U.S. Highway 15 (US 15) is a 791.71-mile-long (1,274.13 km) United States Numbered Highway, serving the states of South Carolina, North...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 301 (US 301) is a spur of U.S. Route 1 running through the South Atlantic states. It runs 1,099 miles (1,769 km) from Biddles Corner, Delaware...

U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula...

U.S. Route 21 or U.S. Highway 21 (US 21) is a north–south United States Numbered Highway, spanning 393 miles (632 km) from Hunting Island State Park, South...

and southwest 18 miles (29 km) to Manning, the county seat. U.S. Route 378 joins US 301 briefly in the center of town, leading west 4 miles (6 km) to...

U.S. Route 56 (US 56) is an east–west United States highway that runs for approximately 640 miles (1,030 km) in the Midwestern United States. US 56's...

Pennsylvania Route 378 (PA 378) is a north-to-south road in Lehigh and Northampton counties in the Lehigh Valley region of the U.S. state of Pennsylvania...

U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 25 or U.S. Highway 25 (US 25) is a north–south United States Numbered Highway that runs for 750 miles (1,210 km) in the Southern and Midwestern...

U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama...

approximately 14 miles (23 km) from the Atlantic Ocean. U.S. Route 701, U.S. Route 501, and U.S. Route 378 pass through Conway. According to the United States...

U.S. Route 74 (US 74) is an east–west United States highway that runs for 515 miles (829 km) from Chattanooga, Tennessee to Wrightsville Beach, North...

U.S. Route 1 or U.S. Highway 1 (US 1) is a major north–south United States Numbered Highway that serves the East Coast of the United States. It runs 2...

numbered 378: Saskatchewan Highway 378 Japan National Route 378 Interstate 378 (former) U.S. Route 378 Georgia State Route 378 Louisiana Highway 378 Maryland...

U.S. Route 319 (US 319) is a spur of US 19. It runs for 303 miles (488 km) from US 98 at the foot of the John Gorrie Memorial Bridge across from downtown...

U.S. Route 190 (US 190) is an east–west United States Highway in Louisiana and Texas. Segments of US 190 will be upgraded to Interstate 14 (I-14); the...